Domain zipping and unzipping modulates TRPM4’s properties in human cardiac conduction disease
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The transient receptor potential melastatin 4 (TRPM4) is a Ca2+-activated nonselective cation channel linked to human cardiac diseases. The human mutation K914R within TRPM4's S4-S5 linker was identified in patients with atrioventricular block. During UV-flash-mediated Ca2+ transients, TRPM4K914R generated a threefold augmented membrane current concomitant with 2 to 3-fold slowed down activation and deactivation kinetics resulting in excessive membrane currents during human cardiac action potentials. Mutagenesis of K914 paired with molecular modeling suggested the importance of the nanoscopic interface between the S4-S5 linker, the MHR4-, and TRP-domain as a major determinant for TRPM4's behavior. Rational mutagenesis of an interacting amino acid (R1062Q) in the TRP domain was able to offset K914R`s gain-of-function by zipping and unzipping of this nanoscopic interface. In conclusion, repulsion and attraction between the amino acids at positions 914 and 1062 alters the flexibility of the nanoscopic interface suggesting a zipping and unzipping mechanism that modulates TRPM4's functions. Pharmacological modulation of this intramolecular mechanism might represent a novel therapeutic strategy for the management of TRPM4-mediated cardiac diseases.The scale effect of heat conduction of air in nano spacing (NS) is very important for nanodevices to improve their life and efficiency. By constructing a special technique, the changes of heat conduction of air were studied by means of measuring the heat conduction with heat conduction instrument in NS between the hot plate and the cooling plate. Carbon nanotubes were used to produce the nano spacing. The results show that when the spacing is small down to nanometer scale, heat conduction plays a prominent role in NS. It was found that the thickness of air is a non-linear parameter for demarcating the heat conduction of air in NS and the rate of heat conduction in unit area could be regard as a typical parameter for the heat conduction characterization at nanometer scale.
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Nanochemistry
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An energy transfer across a system boundary due to a temperature difference by the mechanism of inter-molecular interactions called conduction heat transfer. In the present work, a mathematical model and a simulation based on Energy 2D V 3.0.1 simulator are presented to study the effect of the conduction parameters: thermal conductivity, surface contact area, temperature difference and conduction distance on the heat transferred by the conduction mode.
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This chapter introduces the temperature gradient and Fourier law based on the theory of substance heat conduction. Then, the differential equation of heat conduction is deduced, and the boundary conditions for the definite solution are given. On the basis of understanding the heat conduction, the micro-mechanisms of heat conduction of gases, liquids, and solids are compared, and the relevant formulas for calculating the thermal conductivity of different substances are summarized. Finally, some factors affecting the thermal conductivity of solid materials, including pressure, temperature, and crystal structure, are summarized.
Basis (linear algebra)
Temperature Gradient
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Constant (computer programming)
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Cutting heat conduction undergoes three stages that include intensity transient-state, transient-state, and steady-states. Especially during machining with coated cutting tools, in the conduction process, cutting heat needs to pass through a few micron thick coatings and then flow into the tool body. This heat conduction presents typical non-Fourier heat conduction characteristics. This paper focuses on the cutting temperature in transient heat conduction with a coated tool. A new analytical model to characterize the thermal shock based on the non-Fourier heat conduction was proposed. The distribution of cutting temperature in mono-layer coated tools during the machining was then illustrated. The cutting temperature distribution predicted by the Fourier heat conduction model was employed to compare with that by non-Fourier heat conduction in order to reveal the non-Fourier heat conduction effect in transient heat conduction. The results show that the transient heat conduction analytical model is more suitable for the intensity transient-state and transient-state in the process of cutting heat conduction.
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Conduction shape factors are frequently used in a variety of heat transfer applications to evaluate heat transfer from one three-dimensional body to another three-dimensional body. Previous investigators have used conduction shape factors derived using the 2-D cross-section of the 3-D geometries for non-heating conditions as approximations to 3-D conduction shape factors with heating and no-heating present. This paper investigates the suitability of neglecting the axial conduction and power deposition in deriving expressions for conduction shape factors for the case of a single, cylindrical vessel imbedded concentrically in a cylindrical, uniformly heated tissue matrix. It is shown that 1) conduction shape factors are functions of the deposited power and the temperature distribution and 2) the magnitudes of conduction shape factors are affected significantly by axial conduction.
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This chapter focuses on the study of conduction problems in steady or stationary state. In these cases, temperature will not be a function of time, but it will nevertheless depend on the coordinates that define the position of a given point of the solid considered. Studying steady-state conduction is of particular importance for the engineer. While the single-layer wall represents an interesting practical case for the engineer, study of conduction through walls composed of several layers of different materials presents even greater importance. The study of conduction in cylindrical walls is of great importance, particularly since it allows the heat dissipations through these walls to be calculated. In industry, the people often encounter conduction through spherical walls, notably in storage reservoirs. The chapter presents a study of the problems with convective-type boundary conditions, for single-layer walls, cylindrical pipes and spherical walls, respectively.
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