An ode to the Node: 10 years in the life of a community blog
0
Citation
3
Reference
10
Related Paper
Abstract:
In 2009, we asked our authors and readers for feedback on how the journal was doing and for suggestions of new ways we could serve and support the community. Many responses concerned our rather limited online presence. Our website, for instance, was deemed outdated, and so in January 2010 we relaunched it with a new design and improved navigation. But there were also calls to think about doing something different: could we create an online space for the global developmental biology community to interact, exchange ideas, advertise positions and events, and so on? Nothing like it existed at the time, and the idea seemed timely. As a community journal, Development was also well-placed to host such a site, and so we decided to go ahead with the project, with new Editor in Chief Olivier Pourquié at the helm. Funding from our publisher, The Company of Biologists, allowed us to develop and market the site, and to hire a dedicated website Community Manager, Eva Amsen, to run it. And so, in June 2010, the Node (thenode.biologists.com) went live. Named both after a connection point in a network and an eminent embryonic organiser, the Node would be a ‘community-based, one-stop shop for developmental biologists’ (Amsen et al., 2010).In the decade since launch, although the Node has undergone a couple of redesigns and added some new features, the format and functionality has stayed the same: a blog (with newest posts appearing at the top of the homepage), a jobs board and an events calendar. It's perhaps still under-appreciated that anyone can contribute to the Node: all you have to do is register for an account and start posting. Any moderation by the Community Manager is ‘post-publication’, although of course we're happy to provide feedback on drafts. Readers can also comment on and rate posts. The Node is intended to be your site – a place where anyone in the community can post on any topic of relevance.Blog posts (of which there have been 2488 so far) have covered everything from meeting reports to research highlights, image competitions to topical discussions, career stories to society calls. They have been written by authors from across the world, from undergraduates to professors, singly or in groups. Posts can be as simple as a call for information, or as extensive as a five and a half thousand word historical portrait (by Máté Varga, thenode.biologists.com/doctor-delayed-publications-remarkable-life-george-streisinger/careers). We have also run regular series of posts: ‘Forgotten Classics’, on unjustly neglected papers in developmental biology; ‘A day in the life of an X lab’, showcasing the diversity of developmental model organisms (Xenopus inaugurated the series; onychophorans are the most recent addition); ‘The people behind the papers’, our interview series that puts faces to the names on the author list (and that, in 2018, migrated to print in Development); and an alternative careers series, on all the other things scientists can do with their PhDs. Our jobs board (1172 jobs posted so far) is consistently well-read, and we often hear from people who got their ideal job, or their ideal student or postdoc, thanks to it. Our events calendar (1654 events posted so far) provides a promotional platform for organisers of meetings big and small. Finally, in 2015 we added a dedicated resources page, which contains useful links covering advocacy and outreach, education, audiovisuals and research methods. The page was greatly improved in 2017 thanks to an intern, Sarah Morson, who worked with the British Society for Developmental Biology's Communication Officer, Andreas Prokop.Although Community Managers have changed – Eva was followed by Catarina Vicente in 2013, and Catarina by Aidan Maartens in 2016 – the role continues to be vital, as we have discussed previously (Vicente et al., 2017). As well as maintaining the site and commissioning new content, the Community Manager can act as a new blogger's first reader or editor – we know it can be daunting to put writing online. Our experience of running the Node has also helped guide the design and implementation of The Company of Biologists' two newer community sites, preLights (preprint highlighting by early career researchers, prelights.biologists.com) and FocalPlane (Journal of Cell Science's site devoted to imaging, focalplane.biologists.com). Like the Node, these sites embody The Company of Biologists' motto of ‘supporting biologists, inspiring biology’.Another way the Node serves the developmental biology community is via social media: our Twitter account (twitter.com/the_Node) is fast approaching 15,000 followers and has become a hub for developmental biology in a much more dynamic and responsive way than the blog format provides. We hope the feed serves as a resource in itself – follow us and you'll find the latest research, discussions, beautiful images and movies, historical perspectives and job offers, and the odd groan-inducing pun.More recently, in January 2020 we launched the Node Network (thenode.biologists.com/network/), a global database of developmental and stem cell biologists. The Network aims to make it easier for you to find people for professional purposes (reviewers, panellists or speakers, for example), and importantly can also be used with diversity in mind (members can voluntarily add information about gender, ethnicity and disability status). We strongly believe in the benefits of diversity and inclusion in science (Briscoe and Brown, 2020), and hope that the Network will help diversify conferences, reviewer pools and panels. The Network currently has 717 members from 40 countries, with new PIs being the most represented career stage. Please consider using the Network if you are struggling to find the right scientist, and do consider becoming a member if you want to increase your visibility.Ten years in, and the numbers are good. The Node has been viewed over two million times, and we now regularly receive more than 30,000 page views per month. We are helped by a continual stream of new content: a blog post, job or event is typically uploaded every day. But as well as reflecting on the journey so far, we want to use this anniversary to think about where we're going, and how we can continue to serve and stay relevant to the community in a changing scientific and communication environment. In April we conducted a community survey (11 years after the one that spurred the Node into being), and noises were generally positive from the respondents – most of our features were considered useful, and most of our content enjoyable to read. We also asked what kind of things readers would like to see more of and were given some great ideas to work on, like more interactive content (‘ask me anything’ posts or webinars), ‘how to’ and technical posts, historical features and pieces on the scientific career ecosystem. We are currently developing these ideas and, as ever, will need authors: if you are interested in trying out scientific writing in an informal context about any of the above (or indeed anything relevant to the community), just get in touch or register for an account.Ten years ago, the Node was an experiment, and it really was not clear whether it would still be around a decade later. Today, the Node is a vibrant hub for researchers worldwide, with an ever-increasing readership and a host of new ideas for the future. Who knows where we'll be in 2030?Keywords:
Ode
In response to DNA damage, p53 undergoes post-translational modifications (including acetylation) that are critical for its transcriptional activity. However, the mechanism by which p53 acetylation is regulated is still unclear. Here, we describe an essential role for HLA-B-associated transcript 3 (Bat3)/Scythe in controlling the acetylation of p53 required for DNA damage responses. Depletion of Bat3 from human and mouse cells markedly impairs p53-mediated transactivation of its target genes Puma and p21 . Although DNA damage-induced phosphorylation, stabilization, and nuclear accumulation of p53 are not significantly affected by Bat3 depletion, p53 acetylation is almost completely abolished. Bat3 forms a complex with p300, and an increased amount of Bat3 enhances the recruitment of p53 to p300 and facilitates subsequent p53 acetylation. In contrast, Bat3-depleted cells show reduced p53–p300 complex formation and decreased p53 acetylation. Furthermore, consistent with our in vitro findings, thymocytes from Bat3-deficient mice exhibit reduced induction of puma and p21, and are resistant to DNA damage-induced apoptosis in vivo. Our data indicate that Bat3 is a novel and essential regulator of p53-mediated responses to genotoxic stress, and that Bat3 controls DNA damage-induced acetylation of p53.
Cite
Citations (125)
Ode is a kind of style between poem and articl.However,what is ode? No certain key.Ode's style character is essentially ruleless.So the subject is taken as the criterion to judge if a piece of writing is ode or not.Because of the rulelessness of ode,Ode encountered the situation of polarization in Tang dynasty.On the one hand,the rule was strengthened.On the other hand,the rule was weakened.The former took rhythm ode as representation.The latter resulted in Ode's no literary character.
Ode
Representation
Cite
Citations (0)
Testing ode in imperial examinations had been held before the first year of Shenlong of emperor Zhongzong rather than after that. And the appearance of the ode with limitation was not the result of enlisting prodigies by means of odes;the limitation of rhyme was not begun in the second year of Kaiyuan . Testing ode in examination had not only positive effect on the writings of ode in Tang Dynasty,but also negative influence.
Ode
Emperor
Cite
Citations (0)
Holcus lanatus
Cite
Citations (21)
Hong Mai in Song Dynasty regarded Du Mu's Ode to Afang Palace as imitation of Yang Jingzhi's Ode to Huashan Mountain. Today it is thought that Ode to Afang Palace lack original approach and contains many empty words. The reason why Ode to Afang Palace is on the lips is that it is rich in Ode to Afang Palace words and expressions. It is concluded in this paper that Ode to Afang Palace is an excellent prose.
Ode
Fang
Cite
Citations (0)
HLA-B-associated transcript 3 (BAT3) was originally identified as one of the genes located within human major histocompatibility complex. It encodes a large proline-rich protein with unknown function. In this study, we found that a fragment of the BAT3 gene product interacts with a candidate tumor suppressor, DAN, in the yeast-based two-hybrid system. We cloned the full-length rat BAT3 cDNA from a fibroblast 3Y1 cDNA library. Our sequence analysis has demonstrated that rat BAT3 cDNA is 3617 nucleotides in length and encodes a full-length BAT3 (1098 amino acids) with an estimated molecular mass of 114,801 daltons, which displays an 87.4% identity with human BAT3. The deletion experiment revealed that the N-terminal region (amino acid residues 1-80) of DAN was required for the interaction with BAT3. Green fluorescent protein-tagged BAT3 was largely localized in the cytoplasm of COS cells. Northern hybridization showed that BAT3 mRNA was expressed in all the adult rat tissues examined but predominantly in testis. In addition, the level of BAT3 mRNA expression was more downregulated in some of the transformed cells, including v-mos- and v-Ha-ras-transformed 3Y1 cells, than in the parental cells.
Cite
Citations (21)
SUMMARY A hitherto unrecorded virus having flexible rod‐shaped particles about 740–760 × 13 nm was isolated from Anthoxanthum odoratwn L. It was transmitted by sap inoculation, but not by several species of insect, seed or soil to 18 species of Gramineae including wheat, oats and barley. In susceptible species the virus normally produced a mosaic mottling of the leaves which was sometimes followed by a necrotic streaking or striping.
Mosaic virus
Cite
Citations (6)
Ode
Psyche
Soul
Cite
Citations (0)
Each ode in this book deals with abstract concepts, emotions and objects and is coupled with its opposite. For example, Ode to Fire is coupled with Ode to Rain. Each ode is written is Spanish and English and is prefaced by pencil drawings. Neruda won the 1971 Nobel Prize for Literature.
Ode
Pencil (optics)
Cite
Citations (1)