Effect of oral anticoagulants on hemostatic and thromboembolic complications in hip fracture: A systematic review and meta‐analysis
Yan XuDaniel YouHalli KrzyzaniakBrett PonichPaul E. RonksleyLeslie SkeithPaul SaloRobert KorleyPrism S. SchneiderMarc Carrier
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Hip fracture patients on oral anticoagulants (OACs) experience increased time-to-surgery and higher mortality compared to non-anticoagulated patients. However, it is unclear whether pre-injury OAC status and its associated operative delay are associated with worsening of peri-operative hemostasis or an increased risk of postoperative thromboembolism.We performed a systematic review to identify studies that directly compared hemostatic and thromboembolic outcomes among hip fracture patients on an OAC prior to admission with those not on anticoagulants. Random effects meta-analyses were used to pool all outcomes of interest (estimated blood loss, transfusion requirements, and postoperative thromboembolism).Twenty-one studies involving 21 417 patients were included. Estimated blood loss was higher among patients presenting with OACs compared to those not anticoagulated (mean difference 31.0 mL, 95% confidence interval [CI] 6.2-55.7). Anticoagulated patients also had a 1.3-fold higher risk of receiving red blood cell transfusions (odds ratio [OR] 1.34, 95% CI 1.20-1.51); however, rates of postoperative thromboembolism were similar regardless of anticoagulation status (OR 0.96, 95% CI 0.40-2.79 for venous thromboembolism; OR 0.58, 95% CI 0.25-1.36 for arterial thromboembolism). No subgroup effect was found based on anticoagulant type or degree of surgical delay.Hip fracture patients on OACs experience increased surgical blood loss and higher risk of red blood cell transfusions. However, the degree of surgical delay did not mitigate this risk, and there was no difference in postoperative thromboembolism. The impact of appropriate, timely OAC reversal on blood conservation and expedited surgery in anticoagulated hip fracture patients warrants urgent evaluation.Keywords:
Hip Fracture
Clotting factor
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Objective To determine the safety and efficacy of the homemade extravascular hemostasis device in comparison with standard manual compression after diagnostic and interventional coronary procedures.Methods Two hundred and ninety-nine patients who underwent diagnostic or interventional coronary procedures were randomized to the homemade extravascular hemostasis device or standard manual compression.The primary study end points were time to hemostasis and ambulation and the incidence of major vascular complications.Results Both time to hemostasis and ambulation were significantly reduced in the homemade extravascular hemostasis device,respectively(5.2±4.7)min vs(15.1±12.6)min,(187.4±125.6)min vs(324.8±212.4)min(P0.001).But the incidence of vascular complications was similar between the homemade extravascular hemostasis device group and manual compression group.Conclusion The homemade extravascular hemostasis device allows immediate arterial sheath removal after both diagnostic and interventional procedures,dramatically reducing time to hemostasis and patient ambulation without compromising patient safety in comparison with standard compression techniques.
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This chapter contains sections titled: The ideal vascular hemostasis device Origin of FDA concern with the postmarket performance of hemostasis devices FDA study to evaluate the risk associated with hemostasis device use Possible reasons for FDA findings of apparent protective effects of hemostasis devices Follow-up FDA study to assess the safety of hemostasis devices Conclusion References
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To study the hemostasis effect of disposable packing hemostasis on bleeding due to trauma of medium-sized artery,and compare the hemostasis effect with that of styptic powder.9 miniature pigs were divided into packing hemostasis group,styptic powder group and blank group.Establishing bleeding of forelimb medium-sized artery models on miniature pigs,haemostasis treatments were performed on individual group and parameters were measured,such as hemostatic time,regional maximum temperature and blood pressure.In addition,the tissues surrounding the haemostatic spot were picked for observation.When comparing the haemostatic effect,we found that the disposable packing hemostasis and styptic could stop bleeding quickly,and the effect of these two methods on hemostatic time has no difference;the temperature raised by styptic powder were higher than that of packing hemostasis,in addition,they all cause light tissue damage for raw surface and surrounding tissues.Disposable packing hemostasis could effectively stop bleeding caused by forelimb medium-sized artery,it could act as a secure and effective dressing for treating acute hemorrhage.
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[Purpose] This study assessed the advantages and shortcomings of methods for hemostasis in patients who had received angiography after femoral arterial puncture using manual, compression device, or a combination of manual compression and a compression device. In addition, the success rates, complications, etc, were analyzed. [Subjects and Methods] One hundred and eighty patients who had undergone angiography after femoral arterial puncture were divided into three groups according to the method of hemostasis. For group A, immediately after angiography, an Angio-Seal device was placed in the puncture area and compressed using a compression device. For group B, after angiography, the puncture area was compressed with the hands directly. For group C, the puncture area was compressed using a compression device for approximately 10 min, and the puncture area was then compressed with the hands. In each group, the following correlations were analyzed: the time to hemostasis after angiography and gender, the time to hemostasis of each generation and the hemoglobin value, and platelet value and the time to hemostasis. [Results] The results showed a similar time to hemostasis regardless of gender or generation. The correlation between the hemoglobin value, platelet value, and the time to hemostasis were not significant. Group A showed the shortest mean time to hemostasis of the three groups (20.37 ± 8.23 min). No complications caused by the hemostasis method were detected in group B. Group A showed the highest incidence of complications caused by hemostasis. [Conclusion] Overall, hemostasis performed mutually is safe and effective for patients according to their condition.
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Hemostasis is the normal process that produces a blood clot at a site of vascular injury. Mice are widely used to study hemostasis and abnormalities of blood coagulation because their hemostatic system is similar in most respects to that of humans, and their genomes can be easily manipulated to create models of inherited human coagulation disorders. Two of the most widely used techniques for assessing hemostasis in mice are the tail bleeding time (TBT) and saphenous vein bleeding (SVB) models. Here we discuss the use of these methods in the evaluation of hemostasis, and the advantages and limits of using mice as surrogates for studying hemostasis in humans.
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Newborns have high risks of thrombotic and hemorrhagic complications. Despite the fact that the overall frequency of thrombosis and bleeding in the general population of neonates is low, the risks of both thrombosis and hemorrhage are significantly increased when a newborn has some complications, including prematurity. The mechanisms underlying the onset of thrombotic and hemorrhagic complications in newborns are not fully understood and remain controversial. The hemostasis in newborns drastically differs from adult hemostasis and even from hemostasis in children older than a year. Nevertheless, despite the presence of quantitative and qualitative differences of almost all parameters of the hemostasis system from the parameters of adults, healthy newborns as a whole have clinically normal functional hemostasis without a tendency to coagulopathy or thrombosis. Apparently, the neonatal hemostasis system is in some alternative "balance", which differs from the "balance" of hemostasis in adults. The issue regarding the stability of this balance is still open. Due to the peculiarities of the newborn's hemostasis, clinical laboratory diagnostics of the coagulation disorders is very difficult, and the attending physician is forced to focus exclusively on the clinical picture. This review provides basic information on the neonatal hemostasis system, as well as an attempt to critically evaluate existing laboratory tests in terms of applicability for this group of patients.
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Patients undergoing orthognathic procedures can require blood transfusions. The objectives of this study were to evaluate the predictors of intra-operative blood loss in patients undergoing orthognathic procedures and the transfusion rates and practices of our institution.This retrospective study included 92 patients who underwent the following four types of orthognathic procedures: Group 1, bimaxillary; Group 2, bimaxillary with bone grafts; Group 3, LeFort I osteotomies; and Group 4, LeFort I osteotomies with bone grafts. The intra-operative blood loss, operative time, age, gender and pre- and post-operative HGB and HCT were assessed.The mean blood loss for all groups was 650 ± 397.8 mL, and there were differences in blood loss between the four groups (p = 0.211). The mean operative time was 5 hours and 32 minutes. There were no differences in intra-operative blood loss between the genders or the BMI categories. The operative time was moderately correlated with the intra-operative blood loss (p < 0.001, r =0.332). Eighteen of the 92 patients (19.5%) received blood transfusions. The mean intra-operative blood loss was higher among the patients who received transfusions (p < 0.001).The only predictor of intra-operative blood loss was operative time. The observed transfusion rate was higher than those that have been reported for similar procedures; thus, our institution needs to revisit our transfusion policy and use more time-efficient techniques in the operating room.
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Coagulation system
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Patients undergoing orthognathic procedures can require blood transfusions. The objectives of this study were to evaluate the predictors of intra-operative blood loss in patients undergoing orthognathic procedures and the transfusion rates and practices of our institution. This retrospective study included 92 patients who underwent the following four types of orthognathic procedures: Group 1, bimaxillary; Group 2, bimaxillary with bone grafts; Group 3, LeFort I osteotomies; and Group 4, LeFort I osteotomies with bone grafts. The intra-operative blood loss, operative time, age, gender and pre- and post-operative HGB and HCT were assessed. The mean blood loss for all groups was 650±397.8 mL, and there were differences in blood loss between the four groups (p = 0.211). The mean operative time was 5 hours and 32 minutes. There were no differences in intra-operative blood loss between the genders or the BMI categories. The operative time was moderately correlated with the intra-operative blood loss (p < 0.001, r =0.332). Eighteen of the 92 patients (19.5%) received blood transfusions. The mean intra-operative blood loss was higher among the patients who received transfusions (p < 0.001). The only predictor of intra-operative blood loss was operative time. The observed transfusion rate was higher than those that have been reported for similar procedures; thus, our institution needs to revisit our transfusion policy and use more time-efficient techniques in the operating room.
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