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    The effect of lipid-Iowering drugs on serum lipids and apolipoproteins in hypercholesterolemic non-insulin dependent diabetes mellitus (NIDDM)
    Tadasu IkedaHiroshi OchiIzumi OhtaniK. FujiyamaTazue HoshinoYasushi TanakaTatsuo TakeuchiHiroto Mashiba
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    Effect of Pravastation on Serum Lipids, Apolipoproteins and Lipoprotein (a) in Patients with Non-Insulin Dependent Diaabetes Mellitus.
    Endocrinologia Japonica (1992)
    Fumio UmedaJun WatanabeKaoru InoueAkitaka HisatomiKazuo Mimura
    In 43 patients with non-insulin dependent diabetes mellitus (NIDDM) associated with hypercholesterolemia, the effect of pravastatin, a potent HMG CoA-reductase inhibitor, on serum lipids, apolipoproteins and lipoprotein (a) was examined. After 1 to 3 months administration of 10 mg per day of pravastatin, the serum levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL-C) were significantly decreased, while the serum level of high density lipoprotein cholesterol (HDL-C) was significantly increased in patients with NIDDM. The levels of apolipoproteins B (apo B) and E were significantly decreased, while apolipoprotein AI (apo A-I) was not changed by the administration of pravastatin. The atherogenic indices (LDL-C/HDL-C and apo B/apo A-I) were significantly decreased by the administration of this drug. The serum lipoprotein (a), which was increased in the diabetic patients, was not affected by the pravastatin treatment. Plasma glucose and hemoglobin A1c levels were not affected by the treatment. We concluded that pravastatin is a potentially useful agent in the treatment of hypercholesterolemia in patients with NIDDM.
    Citations (16)
    Effect of simvastatin on plasma lipids and apolipoproteins in hypercholesterolemic E3/3 diabetic and non- diabetic subjects.
    G.Ruiu GruiuM.Cassader McassaderR.Gambino RgambinoN.Alemanno NalemannoF.Demichieli Fdemichieli
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    Low-density-lipoprotein (LDL) peroxidation and composition in non-insulin-dependent diabetes mellitus (NIDDM)
    Atherosclerosis (1994)
    C.J. LintottRobert ScottJanet Jarvis
    Low-density lipoprotein
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    The effect of a small dose pravastatin on plasma lipids in postmenopausal hypercholesterolemia associated with non-insulin dependent diabetes mellitus
    Tadasu Ikeda
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    Effects of Smoking on Plasma Lipid Metabolism in Patients with non-insulin Dependent Diabetes Mellitus.
    Korean Diabetes Journal (2001)
    Seon Min JeonYeun Kyung LeeHye Sung LeeBo Wan KimYoung Bok Park
    Carbohydrate Metabolism
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    Effect of itavastatin on lipid metabolism in NIDDM patients with hyperlipidemia
    Atherosclerosis (2000)
    N YamadaYoshiro SaitoY Akanuma
    Hyperlipidemia
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    [Lipids and lipoproteins in diabetes mellitus].
    PubMed (1975)
    J Syllaba
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    Cholesterol is the major atherogenic lipid in NIDDM
    Diabetes/Metabolism Reviews (1997)
    D. J. Betteridge
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    Double-bli placebo-controlled study of the effects of simvastatin on serum lipids and lipoproteins in non-insulin-dependent diabetes mellitus (NIDDM).
    Atherosclerosis (1993)
    M. FarrerP.H. WinocourKevin EvansH.A.W. NeilM F Laker
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    INSULIN SENSITIVITY AND HDL CHOLESTEROL LEVELS IN HYPERLIPEMIC NON-DIABETICS AND NON-INSULIN-DEPENDENT DIABETICS
    Diabetologia Croatica (1993)
    D BabićMartina SučićBoris RočićŽeljko Metelko
    Recent investigations indicate that insulin resistance is closely related to disturbances of some serum lipids and lipoproteins and the aim of this study was to investigate relations between these factors.
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