Distinctiveness of prolonged‐grief‐disorder‐ and depressive‐symptom trajectories in the first 2 years of bereavement for family caregivers of terminally ill cancer patients
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Abstract Objective Grief reactions in bereaved caregivers of cancer patients have been identified individually as distinct prolonged grief disorder (PGD)—and major depressive disorder (MDD)—symptom trajectories, but no research has examined whether the patterns of change (trajectories) for PGD and MDD symptoms synchronize during bereavement. We conducted a secondary analysis study to investigate the construct distinctiveness of PGD and MDD by simultaneously identifying and examining similarities and differences between bereaved caregivers' PGD‐ and depressive‐symptom trajectories from immediately post‐loss through 2 years later. Methods PGD and depressive symptoms were measured for 849 cancer patients' caregivers over their first 2 years of bereavement using 11 grief‐symptom items of the prolonged grief‐13 scale (PG‐11) and the center for epidemiologic studies‐depression (CES‐D) scale, respectively. PGD‐ and depressive‐symptom trajectories were identified using latent class growth analysis with continuous latent‐class indicators (total PG‐11 and CES‐D scores). Concordance of caregiver participants' membership in PGD‐ and depressive‐symptom trajectories was examined by a percentage and a kappa value. Results Five distinct symptom trajectories were identified for both PGD and MDD, with four shared trajectories (endurance, transient‐reaction, resilience, and prolonged‐symptomatic) having different prevalence rankings. Nonetheless, unique trajectories were identified for PGD (potential recurrence) and depressive symptoms (chronically distressed), respectively. Concordance between membership in PGD‐ and depressive‐symptom trajectories was moderate (61.3%, kappa [95% CI]: 0.49 [0.44, 0.53]). Conclusion PGD and MDD are related but distinct constructs indicated by the unique trajectories identified for each, different prevalence rankings for PGD‐ and depressive‐symptom trajectories, and moderate concordance between membership in PGD‐ and depressive‐symptom trajectories, respectively.Keywords:
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This chapter contains sections titled: Introduction What is concordance? Why does poor concordance matter? Why people stop taking medication? Strategies to help people take their medication Helping vulnerable patients to take their medication Attitudes about certain types of medication Self-administration of medication Monitoring the side effects of medication Advance directives Conclusion
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Background:Patient-physician concordance is an important concern in the treatment of elderly patients with hypertension (HT). Treatment that considers concordance is necessary for mutual understanding and therapeutic satisfaction between patients and physicians. However, there have been no studies addressing concordance that objectively analyzed both patient and physician satisfaction before and after treatment.
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During the 1990s, we estimated the genetic contribution to Parkinson's disease risk in a large, population‐based twin registry. Because many unaffected twins were still alive, previous concordance estimates were based on incomplete information. Ninety‐five percent of twins are now deceased. Here, we update concordance and heritability through 2015 using National Death Index data. In total, we identified 30 concordant and 193 discordant pairs. Proband‐wise concordance was 0.20 in monozygotic and 0.13 in dizygotic pairs. Heritability was 0.27 overall, 0.83 in pairs diagnosed ≤50, and 0.19 in pairs diagnosed >50. High concordance in dizygotic twins suggests shared effects of early childhood environment. Ann Neurol 2019;85:600–605
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Delineating patients’ health profiles is essential to allow for a proper comparison between medical care and its results in patients with comorbidities. The aim of this work was to evaluate the concordance of health profiles outlined by ward doctors and by epidemiologists and the effectiveness of training interventions in improving the concordance. Between 2018 and 2021, we analyzed the concordance between the health profiles outlined by ward doctors in a private hospital and those outlined by epidemiologists on the same patients’ medical records. The checks were repeated after training interventions. The agreement test (Cohen’s kappa) was used for comparisons through STATA. The initial concordance was poor for most categories. After our project, the concordance improved for all categories of CIRS. Subsequently, we noted a decline in concordance between ward doctors and epidemiologists for CIRS, so a new training intervention was needed to improve the CIRS profile again. Initially, we found a low concordance, which increased significantly after the training interventions, proving its effectiveness.
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Twin concordance rates are usually reported without reference to the number of parents affected, apparently because the simple demonstration that monozygotic (MZ) twins are more concordant than are dizygotic (DZ) twins is the goal of most twin studies. Depending on the underlying mechanism, however, twin concordance rates can vary widely when conditioned on the number of parents affected. For the generalized single-locus model it is shown that conditional concordance rates in monozygotic twins, along with an estimate of the disorder's prevalence in the population, uniquely specify the underlying parameters of this important model. Knowledge of the exact parameter set is essential for competent genetic counseling.
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The authors systematically reviewed diagnoses in the Veteran Twin Registry and found 62 pairs of twins (69 individuals) in which one or both had affective illness, a frequency of .22 percent (monozygotic [MZ] concordance = 33 percent, dizygotic [DZ] concordance = 0 percent, and MZ/DZ ratio ≥ 11.5). In 40 of the 62 pairs, one or both twins had unipolar depression (MZ concordance = 40 percent, DZ concordance = 0 percent, and MZ/DZ ratio ≥ 8). Bipolar depression was present in 22 pairs (MZ concordance = 20 percent, DZ concordance = 0 percent, MZ/DZ ratio ≥ 3.2). The data indicate that both environmental and genetic factors are important in the etiology of affective illness and present evidence that unipolar and bipolar illness are separate entities.
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Although some scholars suggest that racial/ethnic concordance between physicians and patients will do much to eliminate disparities in medical care, the evidence for concordance effects is mixed. Using nationally representative data with an oversample of blacks and Latinos, this study examines a variety of topics, including beliefs about and preferences for concordance, the effects of concordance on patient experiences, and interactions between expectations and experiences. The results point to the limited effects of concordance in general but illuminate for whom concordance matters most. The results encourage more nuanced and contingent theories. They suggest that racial/ethnic concordance holds little salience in the minds of most black and Latino patients and that discordance has little effect. Nevertheless, there is some evidence that concordance has a positive effect among those who prefer concordance-thus the apparent effects of concordance might reflect the effects of patient choice more than concordance per se. The conclusion sketches policy implications, including the merits of promoting concordance among targeted groups of patients, even in the absence of overall effects on disparities.
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Non-concordance has often been reported as a major contributor to the failure of occlusion therapy for amblyopia. In other fields of medicine the extent of a patient's understanding in areas of the disease and treatment has been shown to have both a direct and indirect effect on subsequent concordance. The aims of this study were to determine the extent of parental non-concordance, to assess their level of understanding in key areas of amblyopia, occlusion therapy, critical period and prognosis, and to discover the parent's own reasons for failing to concord.Parents of children aged 2-7 years receiving a minimum of 1 hour of occlusion for unilateral amblyopia were recruited. Parental concordance was monitored using a diary and their understanding and reasons for non-concordance were assessed by a questionnaire. Concordance was analysed by calculating a concordance index, determining the proportion of non-concordance, and also by classifying the non-concordance on the basis of whether the behaviour was intentional or unintentional and whether the parents were adequately or inadequately informed.Parental non-concordance was defined as failing to occlude less than 80% of the total prescribed time. The median concordance index was 0.75 and the proportion of non-concordant parents was 0.54 (95% CI 0.41 to 0.67) (n = 57). Parental knowledge was poor in areas of the critical period with 23% of parents unaware of an age limit to the treatment. Reasons for non-concordance given by 68% of parents demonstrated poor knowledge.A substantial proportion of the non-concordant parents had poor understanding in areas such as the critical period and errors also occurred in implementing the treatment regimen. Increased parental awareness of the rationale and urgency of the treatment, with reinforcement of details of the regimen, would help to reduce non-concordance with occlusion therapy.
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