Treatment of superficial hemangioma of the skin in infants with dual-wavelength cynergy laser
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Objective To evaluate clinical therapeutic efficacy and safety on infant hemangioma of the skin by using dual-wavelength Cynergy laser.Methods A total of 452 cases infant hemangioma of the skin were treated by using dual-wavelength Cynergy laser.Laser parameters were that energy for pulsed dye laser (PDL) ranged from 10-12 J/cm2,and Nd ∶ YAG 35-60 J/cm2,pulse duration for PDL was 10 ms and for Nd ∶ YAG 15 ms,and pulse delay was the long ext.The spot size was 7 mm.Laser was coupled to chilled air-cooling apparatus (Smartcool,Cynosure).The frequency of treatment was two to four times.The interval of the treatment was 1 month.Results Total response was achieved in 326 cases (72.12 ％),good response in 94 cases (20.80 ％),fair response was achieved in 30 cases (7.08 ％) and poor response was 9 cases had recurrence accounting for 2 ％ within 12 months.Temporary side effects included scar formation in 29 cases (6.42 ％),hyper-pigmentation in 53 cases (11.73 ％),hypo-pigmentation in 24 cases (5.31 ％),and they disappeared after 4 to 6 months.Scalp hemangioma was treated using dual wavelength Cynergy laser.PDL and Nd ∶ YAG was more effective than PDL alone in the treament of scalp hemangioma.No significant differences were found in hair loss between the two models.Conclusions Cynergy multiplex pulsed laser systerm emitting both pulsed dye 585 nm and Nd ∶ YAG 1064 nm wavelength,is a good tool to treat infant hemangioma of the skin.It has the advantage of fast efficacy and less side effects.
Key words:
Hemangioma; Cynergy laserKeywords:
Hair removal
Nd:YAG laser
Pulsed laser
Infantile hemangioma
Introdution: Many different laser systems are available for permanent reduction of unwanted hairs; however, no single laser has been shown to be superior in providing safe and effective hair removal in all skin types. The objective of the study was to evaluate the efficacy and safety of long-pulsed Neodymium-doped Yitrium Aluminium Garnet (Nd:YAG) 1064-nm laser along with cooling device for hair removal in darker skin types. Materials and methods: A total of 85 female patients of Fitzpatrick skin types IV and V with terminal facial and/or non-facial hairs were treated with a long pulsed Nd:YAG laser 1064-nm, (6mm spot size, fluence of 60-100J/cm2 with pulse width of 40 or 60msec and 10-mm spot size, fluence of 36-45 J/cm2 with pulse duration of 15msec. 6 or more consecutive laser treatments were delivered to 160 skin sites at an interval of 6 to 8 weeks. Both the outcome and the adverse events were noted down. Results: There was a significant hair reduction of 60-80% after 6 treatment sessions. Non facial sites like axillae and chest responded slightly better than facial sites. Amongst the facial hairs, side burn showed more reduction than chin and upper lip. Adverse reactions were minimal and included mild pain, transient erythema, perifollicular edema and rarely post inflammatory hyperpigmentation without scarring. Conclusion: The long-pulsed 1064-nm Nd:YAG laser is a safe and effective method of hair reduction in patients of dark skin types. It may require more than 6 sittings to have permanent hair reduction. Side effects were limited and transient.
Erythema
Intense pulsed light
Hair removal
Nd:YAG laser
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Objective To study the clinic effects and adverse reaction of long pulsed 1064nm gentle YAG laser combined with 595nm pulsed dye laser in the treatment of thickening micro-venous malformation. Methods Totally 14 patients were treated by long-pulsed 1064nm gentle YAG laser and 595nm pulsed dye laser, Correlated parameters as follows:long-pulsed 1064 nm gentle YAG laser with 20～40ms pulse width and 3mm spot diameter. The energy density used from 150～240J/cm2. 595nm pulsed dye laser with 6～20ms pulse width and 7mm spot diameter. The energy densityused from12～15J/cm2. Observed the therapeutic effect and side effects after 3～8 treatment times, the interval time is 4～8 weeks. Results 6 cases (6/14) gained complete healing, 5 cases (5/14) gained marked effect, 3 cases (3/14) gained effective therapy, 0 cases was ineffective. There are 3 cases (3/14) with light pigmentation after the course oftreatment, but it can recover in several months, depressed scar were remained in 1 patient (1/14), 1 patient (1/14)showed hyperplastic scar. Conclusion Combined two kinds of laser is higher effective and safe method for the treatment of thickening micro-venous malformation.
Pulsed laser
Intense pulsed light
Energy density
Q-switching
Pulse duration
Laser Treatment
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BACKGROUND Variable-pulse 1,064 nm wavelength lasers have been used with good effectiveness on leg telangiectasias and reticular veins and have shown promising results on facial telangiectasias as well. OBJECTIVE To investigate the effectiveness of a variable-pulse neodymium:yttrium-aluminum-garnet (Nd:YAG) laser using a small spot size in the treatment of facial telangi-ectasias. METHODS Eight male patients (mean age 75 years) underwent a single treatment session using a variable-pulse 1.5 mm spot size Nd:YAG laser with epidermal cooling. Telangiectasia diameters were 0.3 to 2.0 mm. Test sites were performed using three pulse widths (3, 20, and 60 ms), with fluences varying depending on vessel size and response. Full treatments were per-formed using test parameters giving the best response. Thirteen weeks later, the patients returned for final evaluation and satisfaction rating. RESULTS Fluences ranged from 226 to 425 J/cm2, with smaller vessels requiring larger energies. Pulse duration was equally divided between the 20 and 60 ms settings. The shortest pulse width (3 ms) was inferior in all patients. Longer pulse durations achieved superior vessel elimination with minimal immediate purpura and no postinammatory hyperpigmentation. The average mean vessel clearance was 26 to 50% in half of the patients and 51 to 75% in the other half as evaluated by three unbiased dermatologists with extensive laser experience. CONCLUSION A small–spot size Nd:YAG laser using a pulse width of 20 ms or higher appears to be effective in clearing a significant percentage of facial telangectasias with a single pass. The side effects were minimal.
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Abstract Background and Objectives Attempts at using the pulsed dye laser (PDL) operating at 585 nm wavelength and 0.45 milliseconds pulse duration to treat leg veins have been notably unsuccessful. The aim of this study is to evaluate the efficacy and complications of the 595 nm long PDL in the treatment of leg veins. Study Design/Patients and Methods Fourteen patients with 38 lesions were treated using a long PDL equipped with a cryogen spray cooling (CSC) device. Variable pulse durations ranging from 1.5 to 20 milliseconds and energy fluences from 10 to 20 J/cm 2 were utilized depending on the size of treated vessels. All patients received two laser treatments at an interval of 2 months. Results Of patients with veins type 1A and type 1, 6 (100%) and 3 (13%) had complete clearing, respectively. Of patients with veins type 1 and type 2, 18 (78.3%) and 2 (22.2%) lesions showed excellent response, respectively. Hyperpigmentation was the only observed complication lasting several months in 57.9% of treated sites. Conclusions The long PDL operating at 595 nm is a safe and effective treatment for leg veins, especially in type 1A and type1 vessels. Lasers Surg. Med. 35:62–67, 2004. © 2004 Wiley‐Liss, Inc.
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Objective To observe the efficacy and safety of Q-switched Nd:YAG laser on naevus fuscocaeruleus zygomaticus(NFZ).Methods 165 cases were treated with Q-switched Nd:YAG laser,The wave length was 1064nm,energy density was 4.5～6.0J/cm2,diameter of spot was 3mmf,requency was 1～10Hz,wave length was 532nm,energy density was 1.8～2.2J/cm2,diameter of spot was 3mmf,requency was 1～10Hz The therapeutic effects and side effects was evaluated after 3 months treatment.The total tnectment was 2～5 times.Results Totally 45 cases were cured,the average treatment times were 2.6 and the total effective rate was 74.1%.Hyperpigmentation was observed in 89 cases.No scar happened.Conclusion Q-switched Nd:YAG laser therapy is effective and safe treafment for(NF2) and side effects with lighter side effects.
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Abstract Introduction Leg telangiectasias have been reported to have been treated with a variety of lasers. This study was designed to measure response to treatment of leg telangiectasias with a unique coupled 585 nm and 1064 nm pulse. Methods Sixty female patients (24–62 y.o., skin types II–IV) with leg vein varicosities were treated with pulses of a combined 585 nm long pulsed dye (LPDL) and 1064 nm Nd:YAG lasers, which were delivered sequentially using a novel dual laser device. Pulses were placed along the entire length of the targeted veins. A beam diameter of 7 mm with pulses of 10 ms and 9J/cm 2 of fluence for LPDL, and pulses of 30 ms and 80 J/cm 2 for the 106 nm Nd:YAG were utilized and these remained uniform. Time delays between sequential LPDL and Nd:YAG pulses were 125 ms, 250 ms and 500 ms depending on vein diameter of 4, 3 and 2 mm respectively. One or two treatments were given at 2 month intervals, with post‐treatment assessments at 6 months following the final treatment. Patients subjectively assessed the treatment and their results were used to draw up a satisfaction index (SI). Objective assessment was based on clinical photography and computer‐generated data using a vein clearance detection computer program. Results The overall patient satisfaction rate was 47 of 60 patients and the objective assessments, based on blinded evaluation of clinical photography as well as computer assessment, demonstrated good to very good improvement in 47 by photograph evaluation and 49 of 60 patients by computer edge detection data. Conclusions The combination of LPDL and Nd:YAG laser pulses offered efficient treatment of leg veins irrespective of skin type. Results were better on blue and vessels larger than 1 mm. Side effects were minimal and transient. Lasers Surg. Med. 42:769–774, 2010 © 2010 Wiley‐Liss, Inc.
Nd:YAG laser
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【Objective】 To observe and compare the effect of 532 nm and 1 064 nm Nd: YAG laser in the treatment of hemangioma.【Methods】 108 cases of hemangiomas were respectively treated with 532 nm or 1 064 nm wave Nd: YAG laser.Then,observe their changes in the size and color,and compare the effect combined pathological sections.【Results】 After 4 times,the efficiency of 532 nm and 1 064 nm Nd: YAG laser were 75.9%,94.4%,total effective rate was 85.2%,with less adverse reaction.The results of pathological sections showed that,the number of blood vessels was decreased and the vascular space was thinner after 532 nm and 1 064 nm wave Nd: YAG laser irradiation,and the latter was better.【Conclusion】 The result suggests that frequency-doubled Nd: YAG 1 064 nm laser is a safe and effective method in the treatment of skin hemangioma.
Nd:YAG laser
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Telangiectatic leg veins have been treated using lasers with variable success.We aimed to examine the efficacy and tolerability of a 595-nm pulsed dye laser (PDL) and a 532-nm Nd:YAG laser using ultralong pulse duration to improve leg telangiectasias with a single treatment.Ten subjects with leg telangiectasias up to 1.0 mm in diameter participated in the study. The telangiectatic patch was divided into two approximately equal adjacent areas. The first area was treated with a 532-nm Nd:YAG laser at a fluence of 20 J/cm2 and a pulse duration of 50 ms using a contact cooling device. The second area was treated with a 595-nm PDL at a fluence of 25 J/cm2 and a pulse duration of 40 ms using cryogen spray precooling. Each area was treated once only. Photographic evaluation was used for an assessment of response.Two of 10 subjects had less than 25%, 3 had 25% to 50%, 2 had 50% to 75%, and 3 had more than 75% improvement after single treatment with a 532-nm Nd:YAG laser. Similarly, 2 of 10 subjects had less than 25%, 2 had 25% to 50%, and 6 had 50% to 75% improvement with the 595-nm PDL. Hyperpigmentation occurred in one subject treated with the 532-nm Nd:YAG laser and two subjects treated with the 595-nm PDL. No blistering, crusting, hypopigmentation, or scarring were observed.Both lasers using ultralong pulse width improved leg telangiectasias after a single treatment with minimal adverse reactions.
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Hypopigmentation
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Summary Introduction The objective was to investigate the clinical effect of an adjustable pulse width Pulsed Dye Laser ( PDL ) vs an adjustable pulse width PDL combined with fractional CO 2 laser in treating immature red hypertrophic scars. Methods Fifty‐six patients (56 sites)were randomly divided into a treatment group and control group. The control group was treated with the 595 nm PDL at a fluence of 7‐15J/cm 2 and pulse widths of 1.5‐3 ms, 7 mm spot size. The treatment group was treated with a fractional CO 2 laser (UltraPulse CO 2 : Deep FX , Energy: 30~50 mJ , Frequency: 300 Hz, Density 5%, Scan Shape, and Spot Size were decided by shape and area of scar) after utilizing the 595 nm adjustable pulse width PDL (Fluence: 7‐15J/cm 2 , Pulse widths: 1.5‐3 ms, Spot size: 7 mm). MEBT / MEBO , previously described as a post‐treatment wound ointment, was used after laser treatment. The scars of the treatment group and the control group were evaluated for changes in pigment, height, vascularity, and pliability using the Vancouver Scar Scale ( VSS ) after two laser treatments. Results The total VSS score, as well as the score for melanin, height, vascularity, pliability in both groups, showed an obvious decrease following the treatments. There were statistically significant differences between before treatment and after treatment ( P < .05); however, the total score of the VSS , and score of the melanin, height, vascularity, and pliability in the control group decreased more than that of treatment group, and there was a statistically significant difference ( P < .05). Conclusions The 595 nm adjustable pulse width PDL combined with the fractional CO 2 fractional laser appears to have a beneficial clinical effect on fresh red hypertrophic scars, with no severe adverse reactions seen.
Vascularity
Pulsed laser
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Objective To observe the treatment effect of 1 064 nm wave length Nd∶YAG laser with pingyangmycin injection on oral hemangioma. Methods One hundred cases with oral hemangioma were randomly and equally divided into two groups: Nd∶YAG laser+pingyangmycin group and laser alone group. The antibiotic was injected firstly into the tumor with 8 mg each time (total doses 40 mg)till its well became thinner evidently. Then the laser irradiation was used in the form of scattered spots or fences with output power 10-20 W, time 1-2 s and fiberoptic head to focus distance 0 2-4 cm. Results The total effective rate of two groups were 96% and 72%, respectively. Compared with each other, there was a significant difference between them, and the combined treatment group had shorter therapeutic time (45 d vs 92 d) and less side effects. Conclusions The results of this study suggested that combined treatment of Nd∶YAG laser with pingyangmycin injection for oral hemangioma had better therapeutic effects and less side effects.
Pingyangmycin
Nd:YAG laser
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