T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice
Wei LiAhmed S. ElshikhaCaleb CornabyXiangyu TengGeorges AbboudJosephine BrownXueyang ZouLeilani Zeumer-SpataroBrian RobustoSeung‐Chul ChoiKristianna M. FredenburgAmy S. MajorLaurence Morel
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Abstract:
Patients with systemic lupus erythematosus (SLE) present a high incidence of atherosclerosis, which contributes significantly to morbidity and mortality in this autoimmune disease. An impaired balance between regulatory (Treg) and follicular helper (Tfh) CD4+ T cells is shared by both diseases. However, whether there are common mechanisms of CD4+ T cell dysregulation between SLE and atherosclerosis remains unclear. Pre-B cell leukemia transcription factor 1 isoform d (Pbx1d) is a lupus susceptibility gene that regulates Tfh cell expansion and Treg cell homeostasis. Here, we investigated the role of T cells overexpressing Pbx1d in low-density lipoprotein receptor-deficient (Ldlr-/-) mice fed with a high-fat diet, an experimental model for atherosclerosis. Pbx1d-transgenic T cells exacerbated some phenotypes of atherosclerosis, which were associated with higher autoantibody production, increased Tfh cell frequency, and impaired Treg cell regulation, in Ldlr-/- mice as compared with control T cells. In addition, we showed that dyslipidemia and Pbx1d-transgenic expression independently impaired the differentiation and function of Treg cells in vitro, suggesting a gene/environment additive effect. Thus, our results suggest that the combination of Pbx1d expression in T cells and dyslipidemia exacerbates both atherosclerosis and autoimmunity, at least in part through a dysregulation of Treg cell homeostasis.Keywords:
Dyslipidemia
Background: India has seen an ever increasing number of diabetic patients and in turn rise in cardiovascular diseases. Many studies have shown diabetic patients to have dyslipidemia, with certain common patterns early in the disease. Aims and Objective: The current study was done to identify pattern of dyslipidemia and prevalence of ADD in treatment naïve diabetic patients. Material and Methods: Fasting lipid profile was analysed in treatment naïve diabetic patients at a tertiary care teaching hospital. Various factors influencing the results were analysed statistically. Results: Prevalence of dyslipidemia was 89.2%, whereasatherogenic diabetic dyslipidemia was seen in 34.2% and raised non-HDL cholesterol in 73.3%. Conclusion: Our study showed a high prevalence of dyslipidemia in newly diagnosed diabetics indicating the importance of screening for dyslipidemia in newly diagnosed cases and implementation of timely lipid lowering therapy to prevent CVD. It also highlights the importance of pattern of dyslipidemia called Atherogenic diabetic dyslipidemia and raised Non-HDL cholesterol in diabetic patients.
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OBJECTIVE To provide evidences for prevention and treatment of dyslipidemia from analyzing dyslipidemia distribution in staff at government departments in Hefeng country. METHODS The results of examination of 5 043 subjects at government departments were analyzed. RESULTS 2 563 of 5 043 subjects (50.82%), 22 to 91 years old, were with dyslipidemia. There was a significant difference in blood lipid level between subjects with dyslipidemia and normal subjects (P﹤0.05). The prevalence of dyslipidemia in males was higher than in females (P﹤0.05). CONCLUSION Dyslipidemia is correlated with age and gender, which suggests that a reasonable diet, physical activity are beneficial to prevention and treatment of dyslipidemia.
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Recently, the incidence and prevalence of obesity and dyslipidemia are increasing.Dyslipidemia is associated with significant comorbidities and complications, and with cardiovascular risk factors (obesity, diabetes mellitus, hypertension and smoking).The main objectives of this article are that describe the prevalence of dyslipidemia in Korean children and adolescents and review the diagnosis and management of dyslipidemia in children and adolescents.
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It is well known that sera of patients with systemic autoimmunity contain autoantibodies to nuclear antigens. It is also known that patients with systemic autoimmunity have an increased risk for the development of tumours. Interestingly, tumour patients frequently develop autoantibodies and there is a growing list of potential tumour-associated antigens. It is, however, not known whether or not patients with systemic autoimmunity also develop antibodies to tumour-associated antigens. Here we describe the development of a novel multiprotein array allowing us to screen for autoantibodies to 30 different tumour-associated antigens in parallel. Using this novel assay, we found that the frequency of autoantibodies to the selected tumour-associated antigens is increased between 2- and 14-fold in patients with systemic autoimmunity compared with an age-matched control group.
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Aim:To investigate the dyslipidemia risk factors.Methods:Some check-up crowd(263 persons)from Zhengzhou were subjected to detect lipid level in the blood,and investigate the diet habit.Results:The prevalence rate of dyslipidemia was 45.2%,the distribution of the dyslipidemia was different in different age group(χ2=8.467,P=0.014),and the prevalence rate of dyslipidemia was related to body mass index(BMI)and daily intake of alcohol(χ2=11.182,P0.001;χ2=12.550,P0.001).BMI≥24 kg/m2,over-drunk,and age≥45 years were the dangerous factors of dyslipidemia.Conclusion:The prevention of dyslipidemia could be strengthened through the diet adjustment,strengthen prevention,and cure work of dyslipidemia in the youth crowd.
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Objective To explore the prevalence and influencing factors of lipid abnormalities among adult inhabitants in Yinchuan and to provide the theory basis for community intervention of cardiovascular diseases.Methods Serum lipids and physical indices of 1275 urban adults were surveyed in yinchuan.Dyslipidemia prevalence and the related risk factors were analyzed.Results The prevalence of dyslipidemia was 48.6% in adult residents of Yinchuan and male and female prevalence were 50.3% and 40.8 % respectivly.TC and TG in males were significant higher than those in females(P0.01).The dyslipidemia prevalence increased with age rising in both of males and females.Hypertension,body mass index and the WHR possibly were the independent risk factors of dyslipidemia.Conclusion Dyslipidemia prevalence of adults in yinchuan were higher than that of nationwide.the middle-aged and elderly people are key control groups.Controlling both weight and blood pressure levels under the normal range can be effective for preventing dyslipidemia.
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Objective: frequency of dyslipidemia in obese subjects Methodology: In this was a cross sectional study, we included a total of 100 cases, between 30 and 70 years of age of either gender having body mass index >30 whereas we excluded all those cases who were already taking treatment of dyslipidemia. A fasting blood sample was followed for lipid profile from the hospital lab and results were followed for presence/absence of dyslipidemia. Results: In this trial, mean age was 44.57+8.52 years. Mean lipid profile was recorded as 210.17+36.73 total cholesterol, 178.83+12.10 triglycerides, 133.55+9.74 LDL and 34.42+6.58 HDL. Mean Body mass index was calculated as 34.11+7.25. Frequency of dyslipidemia in obese subjects was recorded as 51%(n=51) Conclusion: We concluded that frequency of dyslipidemia is higher in obese subjects coming to a tertiary care hospital Lahore. So, it is recommended that every patient who present with obesity, should be sort out for dyslipidemia. However, it is also required that every setup should have their surveillance in order to know the frequency of the problem Keywords: Obese, dyslipidemia, frequency
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