The diagnostic value of thinprep cytology combined with colposcopy for cervical lesions
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Objective To investigate the diagnostic value of ThinPrep cytology(TCT) combined with colposcopy for cervical lesions.Methods 980 patients with suspected cervical lesions were selected and received TCT combined with colposcopy examination.Among the 980 patients,102 patients with positive smear were referred for colposcopy and were diagnosed by colposcopy biopsy.Results Of 102 patients with positive smear,the detection rates of the atypical squamous cells (ASC),low-grade squamous intraepithelial lesions (LSIL),cervical intraepithelial neoplasia (HSIL) and atypical glandular cells (AGC) were 6.1％,0.6％,2.1％ and 1.5％,respectively.Compared with the colposcopy biopsy for cytology samples,the test results were as follows:LSIL was 72.4％ (21/29),HSIL was 93.8％ (15/16).Conclusion The method of TCT could increase the screening rate of positive diagnosis of cervical lesions and for the highly suspected patients,the combination of vaginal colposcopy and biopsy could further improve the accuracy of diagnosis,in order to provide scientific solutions for clinical treatment.
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ThinPrep cytology; Colposcopy; Cervical lesions; Diagnostic valueObjective:To explore the diagnostic value of liquid-based cytology test (TCT) for gynaecological cervical lesions..Methods:5 010 patients screened for cervical lesions in this hospital from January 2007 to October 2009, were selected to adopt TCT detection and TBS detection of diagnostic classification. The cytology and biopsy results of 351 cases of cytology-positive and 197 patients of cytology-negative with suspicious clinical diagnosis which took colposcopy and multi-point biopsy were compared..Results:The cytology-positive rate was 7.82% in 5 010 patients.. And ASCUS was 5.57%, LSIL 1.44%, HSIL 0.70%, SCC 0.12%.. In 548 patients with colposcopy examination and multi-point biopsy, the cytological positive rate of LSIL or severer lesion was 30.29%(166/548), and histological positive rate of CINⅠ or severer lesion was 35.40%, there was no significant difference(P0.05). The cytological rate of false negative was 30.51% for LSIL, 26.76% for HSIL, 25.00% for SCC, the false positive rate was 22.40% for LISL, 0.00% for HSIL, 0.00% for SCC.Conclusion:Liquid-based cytology test can exactly reflect cervical lesions. It can be used to check cervical cancer with its high clinical application value in screening gynecological cervical lesions. Colposcopy and multi-point biopsy can make up the cytological false negative detection. The final diagnosis of cervical lesions should be determined by histological pathology.
Ascus (bryozoa)
Liquid-based cytology
False positive rate
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Objective To investigate the effectiveness of thinprep cytologic test(TCT) combined with biopsy under colposcopy for diagnosis of cervical squamous intraepithelial lesions.Methods 800 suspicious patients were assigned to receive TCT combined with biopsy under colposcopy(TCT group,380 patients)or biopsy under colposcopy randomly (control group,420 patients).Pathologic examination of biopsy sample was used as gold standard.Results The coincidence on diagnosis of cervical lesions between TCT group and pathologic exanmination of biopsy sample was 75.0%(285/380),the coincidence on diagnosis of cervical lesions between control group and pathologic exanmination of biopsy sample was 49.5%(208/420),the difference was significant (P0.01).Conclusion TCT combined with biopsy under colposcopy may be a reliable method to screen and diagnose the precancerosis of cervix.
Gold standard (test)
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Objective To investigate the effectiveness of thinprep cytologic test(TCT)combined with biopsy under colposcopy for diagnosis of cervical squamous intraepithelial lesions(CIN).Methods 519 suspicious patients were assigned to receive TCT combined with biopsy under colposcopy(TCT group,268 patients) or biopsy under colposcopy randomly(control group,251 patients).Pathologic examination of biopsy sample was used as gold standard.Results The coincidence on diagnosis of cervical lesions between TCT group and pathologic examination of biopsy sample was 72.0%(193/268),the coincidence on diagnosis of cervical lesions between control group and pathologic examination of biopsy sample was 50.1%(126/251),the difference was significant(χ2=388.62,P0.005).Conclusion TCT combined with biopsy under colposcopy may be a reliable method to screen and diagnose the precancerosis of cervix.
Gold standard (test)
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Objective To determine the diagnosis value of liquid-based cytology( TCT) combined with colposcopy in cervical lesions screening. Methods 1 138 women received TCT,and 195 of them got colposcopy and autopsy,diagnosis results were compared with Histopathology. Results 195 out of 1138( 17. 14%) TCT examinations were cytology positive,157 cases( 13. 80%) were Atypical squamous cells( ASCUS),28 cases( 2. 46%) were low-grade squamous intraepithelial lesions( LSIL) and 10 cases( 0. 88%) were high-grade squamous intraepithelial lesions( HSIL). All positive cases and clinical highly suspicious cytology cervical lesions patients underwent colposcopy and endoscopic biopsy pathology. 139 cases( 71. 28%) had abnormal colposcopy images. And compared with histological,ASCUS( CINI66 cases,CIN Ⅱ 1 case),LSIL( CIN Ⅰ 13 cases,CIN Ⅱ 2 cases,CIN Ⅲ 6 cases, SCC1 cases); HSIL( CIN Ⅱ 3 cases,CIN Ⅲ 3 cases,SCC4 cases). Conclusion Cervical lesions screening by liquid-based cytology( TCT),with Biopsy pathology under colposcopy,Cervical lesions could be determined and prevented if cytology positive.
Ascus (bryozoa)
Histopathology
Liquid-based cytology
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Objective It is to evaluate the diagnostic value of Thinprep liquid based cytology test(TCT) combined with colposcopy in screening of cervical disease.Methods TCT combined with colposcopy diagnosis of the cases in Quhua Hospital from May,2006 to November,2006 was compared with histopathology diagnosis.Results TCT diagnosis in 150 cases included 61 cases of ASCUS,2 cases of ASCH,35 cases of LSIL,21 cases of HSIL and 1 case of SCC.The conformity rate of TCT and histopathologic diagnosis(88.4%) was greater than that of colposcopy and histopathology diagnosis(63.1%).Conclusion TCT is benefit to improve the conforming to histopathologic.The abnormal results of TCT and the suspicious clinical cases ought to diagnose biopsy of vaginoscopy for the early treatments.
Histopathology
Ascus (bryozoa)
Liquid-based cytology
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Objective To investigate the clinical value of thinprep cytology test(TCT) combined with colposcopy in diagnosis of cervical lesion. Methods Retrospective analysis was conducted in 174 females with abnormal cervical smear. All the patients underwent colposcopy to screen the cervical lesions. According to the pathological results,the clinical value of TCT and colposcopy was analyzed and compared. Results In the 174 cases with abnormal cervical smear,the positive rate of atypical squamous cells(ASC) was 27. 0% (47/174). There were 92 low grade squamous intraepithelial lesion (LSIL) (52. 9%) ,33 high grade squamous intraepithelial lesion (HSIL) (19. 0%) and 2 squamous cell cancinoma (SCC) (1. 1%) . According to the diagnosis by biopsy and pathology,the positive rate of benign cervical cell(BCC) was 16. 1% (28/174) .cervical intraepithelial neoplnsia (CIN) I 42. 0% (73/174), CIN II 18.4% (32/174), CIN ffl 21. 8% (38/174) and SCC 1. 7% (3/174) . The coincidence rate of TCT and pathology was 83. 9% (146/174). Conclusions TCT and colposcopy are a practical approach for detecting cervical lesion. TCT combined with colposcopy is the optimal screening approach for cervical lesion, which can enhance the sensitivity and specificity of the diagnosis of cervical lesions.
Key words:
Thinprep cytology test; Cervical intraepithelial neoplnsia; Colposcopy; Biopsy
Squamous intraepithelial lesion
Ascus (bryozoa)
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Objective To investigate the TCT combined colposcopy biopsy in the diagnosis of cervical lesions in the application.Methods from November 2006 to September 2009 attendance at the Suzhou Kowloon Hospital 8 377 cases of patients undergoing outpatient gynecological TCT,in which cytology-positive patients in parallel to further colposcopy biopsy.Results The cytology-positive patients,225 cases,of which ASCUS142 cases,LSIL 41 cases,HSIL 33 cases of pathology consistent with rates of 73.9%,53.7%,51.5%.225 cases of cervical biopsy colposcopy CIN were found in more than 105 cases of cases pathology accounted for the positive rate(46.7%).CIN and carcinoma in situ of age mainly in the 20-49 years of age,CIN occurred in the 20-39 years of age accounted for 58.1%.Conclusion TCT and pathological histology have a higher line rate,the joint colposcopy biopsy can improve the detection rate of cervical lesions can be used as diagnostic methods for cervical lesions.
Outpatient clinic
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Objective To study the value of thinprep cytology test(TCT) combined with the results of cervical biopsy by colposcopy in diagnosis of cervical lesions.Methods Retrospective analysis of 11 361 cases examined with TCT and TBS diagnosis,some positive cases with TCT did cervical biopsy by colposcopy and histopathological examination.Results There were 638 positive cases of 11 361 cases,the positive ratio was 5.62%,and were mainly distributed during the age of 30 to 39.Among them,390 cases were analyzed with pathologic biopsy by colposcopy,and to be divided into the following subsets: 355 cases for atypical squamous cell(ASC,3.12%),219 cases for low-grade squamous intraepithelial lesion(LSIL,1.93%),39 cases for high-grade squamous intraepithelial lesion(HSIL,0.34%),2 cases for squamous cell carcinoma(SCC,0.02%).Compared with the positive rate and coincidence rate from the pathologic diagnosis,SCC 100%,100%;HSIL 100%,83.33%;LSIL 68.60%,62.32%.Conclusion TCT technique combined with cervical biopsy by colposcopy is a reliable means to screen and diagnose cervical cancer and precancerous lesions.
Squamous intraepithelial lesion
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The Clinical Application of Thinprep Liquid-based Cytology Test in the Diagnosis of Cervical Lesions
Objective To evaluate the clinical value of thinprep liquid-based cytology test (TCT) combined with colposcopy in the diagnosis of cervical lesions. Methods 2200 cases of patients were detected by Thinprep liquid-based cytology from January to July 2006. The diagnosis criteria were based on the Bethesda system(TBS). And 34 positive cases were examined by colposcope. Results A total of 34 cases were positive smear,or 1.54 %,of which does not atypical squamous cells(ASCUS) 18 cases,accounting for 0.81%;low squamous intraepithelial neoplasia(LSIL) 9 cases,accounting for 0.41%;highly scales-intraepithelial neoplasia(HSIL) 6 cases,accounting for 0.12%;squamous cell carcinoma (SCC) 0 case,adenocarcinoma (AC)0 case. Colposcopy and biopsy diagnosis rates were LSIL 94.4%,HSIL 100%. Conclusion Women of child-bearing age(20～50) should be conducted on a regular Thinprep liquid-based cytology,which is early detection of cervical lesions. Positive cytology should be in line with vaginal examination of biopsy and pathological diagnosis,in order to further clarify the diagnosis and early treatment.
Ascus (bryozoa)
Liquid-based cytology
Bethesda system
Squamous intraepithelial lesion
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Microcolposcopy is an in vivo cytological examination of the uterine cervix allowing the localization of exoendocervical precancerous lesions. The aim of this study was to assess the diagnostic reliability of microcolposcopy by means of correlation with histology, colposcopy and Pap test results. For the study, 256 patients with abnormal Pap test results were selected and subjected to colposcopy and microcolposcopy with the aim of evaluating the presence of any intraepithelial lesions. One hundred and nine of these patients were subjected to a biopsy. Colposcopy, histology and cytology results were compared with those obtained by microcolposcopy. In low-grade squamous intraepithelial lesion (LSIL) cytology cases, the percentage agreement on lesion grade between Pap test and microcolposcopy results was 74%, while in high-grade squamous intraepithelial lesion (HSIL) cytology cases, it was equal to 80%. The comparison between colposcopy and microcolposcopy showed a level of agreement of 72% for lower grades and 68% for higher grades. Finally, histology was in agreement with microcolposcopy in 73% of cervical intraepithelial grade 1 neoplasia (CIN 1) cases and reached 71% for CIN 2-3. Microcolposcopy proved to be accurate with regard to the diagnosis of lesion grade, and showed to be definitive in patients where cytology was positive for HPV infection and colposcopy was not able to identify any lesions.
Squamous intraepithelial lesion
Histology
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