Effect of deferoxamine mesylate on occupied volume and 90 days prognosis in patients after intracerebral hemorrhage
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Abstract:
Objective
To study the effect of deferoxamine mesylate on occupied volume and 90 days prognosis in patients after intracerebral hemorrhage (ICH).
Methods
Forty-two ICH patients, admitted to our hospital from February 2013 to May 2014, were chosen in our study and divided into deferoxamine mesylate treatment group and control group (n=21); the occupied volumes and its changed trends of ICH in the two groups were compared; modified Rankin scale(mRS) was used to evaluate the 90 days prognosis.
Results
The difference of the relative occupying volume between the deferoxamine mesylate treatment group and control group on the 4th day was statistically significant (1.44±0.33 vs. 1.91±0.53, t=-3.459, P=0.001). The difference of the variation of the 1st to 4th day relative occupied volume and the 8th to 15th (or discharge) day relative occupied volume was statistically significant: the growth amount of the 1st to 4th day relative occupied volume of the control group was significantly higher than that of deferoxamine mesylate treatment group (P<0.05): the absorbed amount of 8th to 15th (or discharge) day relative occupied volume of the control group was statistically higher than that of deferoxamine mesylate treatment group (P<0.05). There was no significant difference in mRS scores between two groups on the 90th day (±7 days) (χ2=0.000, P=1.000).
Conclusion
Deferoxamine mesylate may reduce the growth amount of 1st to 4th day relative occupied volume and absorbed amount of 8th to 15th (or discharge) day relative occupied volume after ICH, but not influence the 90 days prognosis.
Key words:
Intracerebral hemorrhage; Deferoxamine; Occupied volume; PrognosisKeywords:
Mesylate
Objective To explore the impact of perdipine to haemodynamics and the concentration with serum Ca2+,Mg2+ in the early onset severe preeclampsia.MethodsEarly onset severe preeclampsia were randomly divided into two groups: group A(perdipine treatment group) of 66 cases;Group B(phentolamine treatment group) of 67 cases.Testing before and after treatment in blood pressure,serum Ca2+,Mg2+ concentration and protein in urine changing,and so on.Results①Changes in blood pressure: systolic blood pressure and diastolic blood pressure decrease before and after treatment in each group,mainly in systolic blood pressure decreased,the decline of group A was particularly significant,group A with significant differences compared with group B(P0.05).Group A reach the level of effect after 3 days,while group B after treatment for 4 days.Group B had found 2 cases of resistant hypertension patients,the incidence rate of 2.99 percent.②Serum Ca2+,Mg2+ concentration changes: in each group after treatment serum Ca2+,Mg2+ concentration have increased,the difference between before and after treatment was significantly(P0.05);and the control group with no significant difference(P0.05).③Compared urinary protein declined: total volume urine protein decrease in each group,before and after therapy the two group had statistical significance(P0.05),the control group with no significant group difference(P0.05).④Pregnancy outcome: the average gestation time of group A was significantly increased than that in group B(P0.05),and fetal Apgar score group A was better than group B,two groups of postpartum hemorrhage,birth weight had no significant difference.ConclusionPerdipine with magnesium sulfate not only has affirmative curative effect in the treatment of early onset severe preeclampsia,but also has some effect on resistant hypertension.It is deserved to be applied.
Group B
Group A
Apgar score
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Objective: To investigate the clinical efficacy of early therapeutic with high dose ulinastatin in the treatment of acute pulmonary contusion. Methods: A total of 102 patients with pulmonary contusion were randomly divided into Group A(n=34, control group), Group B(n=34, regular dose group) and Group C(n=34, high dose group). The patients of Group A received routine treatment,while the patients of Group B were given Ulinastatin(100 kU intravenous drip once every 8 hours and continued 7 days) in addition, and the patients of Group C also were given Ulinastatin(400 kU intravenous drip once every 8 hours and continued 7 days) in addition.Artery oxygen pressure(PaO2), carbon dioxide pressure(PaCO2), oxygenation index(PaO2/FiO2), serum tumor necrnsis factor alpha(TNF-α) and interleukin 6(IL-6) levels were measured on the 1st, 4th and 7th day in these groups. The incidence rates of acute respiratory distress syndrome(ARDS) and pulmonary infection were compared among three groups during the treatment. Results: After treatment,PaO2 in group B was higher than that in group A on 7th day(P0.05), PaO2in group C was higher than that in group A on 1st, 4th and7th day(P0.05), PaO2in group C was higher than that in group B on 1st and 4th day(P0.05); PaCO2in group B and C were higher than that in group A on 4th day(P0.05); PaO2/FiO2in group B was higher than that in group A on 7th day(P0.05), PaO2/FiO2in group C were higher than those in group A and B on 4th and 7th day(P0.05); TNF-α in group B was lower than that in group A on 7th day(P0.05), TNF-α in group C was lower than that in group A on 4th and 7th day(P0.05), TNF-α in group C was also lower than that in group B on 4th day(P0.05); IL-6 in group B was lower than that in group A on 7th day(P0.05), IL-6 in group C was lower than those in group A and B on 4th and 7th day(P0.05). No significant difference was observed in the incidence rates of ARDS and pulmonary infection among three groups during the treatment. Conclusions: Early high-dose application of ulinastatin was obviously effective in the treatment of acute pulmonary contusion.
Ulinastatin
Oxygenation index
Group B
Group A
Pulmonary Contusion
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Objective To investigate the clinical efficacy of pre-hospital mild hypothermia in patients with severe craniocerebral injury,and to explore the possible mechanism by the changes of serum Malondialdehyde (MDA).Methods 120 cases of severe craniocerebral injury were divided into pre-hospital mild hypothermia group (group A,65 cases) and control group(group B,55 cases) by random number table.Patients in group A were gave pre-hospital mild hypothermia treatment,and patients in group B were gave mild hypothermia therapy only after hospitalization.Comparison of the change of serum MDA at admission,the 7th and 14th day between two groups,and the functional outcomes were evaluated by GOS score in 6 months after treatment.Results The MDA levels of two group at seventh days and 14 days were higher than that at admission [(10.4 ± 1.5)nmol/L and (8.2 ± 1.2)nmol/L in group A,(12.6 ± 1.9)nmol/L and (10.0 ± 1.4)nmol/L in group B,P ＜0.05],and it was the highest at 7th day,and its in group A was significantly lower than that in group B at 7th,14th day [(6.9 ± 1.1) nmol/L in group A,(6.6 ±1.0) nmol/L in group B,P ＜ 0.05].The good prognosis rate was 47.7％ (31 cases) in group A,higher than the 38.2％ (21 cases) in group B;The mortality rate was 12.1％ (8 cases) in group A,lower than the 21.4％ (12 cases)the group B,and the difference was statistically significant (Z =-2.132,P ＜ 0.05).Conclusion Pre-hospital mild hypothermia treatment can improve the prognosis of patients with severe craniocerebral injury and alleviate the damage of brain tissues.
Key words:
Brain injuries ; Hypothermia, induced ; Free radicals ; Prognosis
Malondialdehyde
Group B
Group A
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Objective To investigate the effect of treatment with short term kata-echelon glucocorticosteroid on chronic obstructive pulmonary disease(COPD) in acute exacerbation stage(AECOPD).Methods Ninety-six patients with AECOPD in Ⅱ grade were randomly assigned to group A,group B,group C and group D.Group A was treated with regular antibiotics,aminophylline(0.25 g/d),ambroxol hydrochloride,inhaled salbutamol in atomization and oral famotidine(20 mg a time,twice a day).Group B was treated with intravenous drip dexamethasone(10 mg/d from the first day to third day,5 mg/d from the fourth day to sixth day) and other drugs as the same as group A.Group C was treated with intravenous drip methylprednisolone(80 mg/d from the first day to third day,40 mg/d from the fourth day to sixth day) and other drugs as the same as group A.Group D was treated with intravenous drip dexamethasone(5 mg/d from the first day to tenth day) and other drugs as the same as group A.All subjects had the course of 15 days.The expiratary flow volume in the first one second(FEV1),the score of dyspnea,the blood gas analysis,the volume of sputum,the fecal occult blood test,the fasting plasma glucose(FPG),the two-hour plasma glucose(2 h PG),adrenocorticotrophic hormone(ACTH),corticosteroid(Cor),the fasting insulin and the two hour insulin(2 h insulin) after drinking 75 g glucoses two hours had been measured and evaluated before the treatment,after 15 days' treatment and after one month's post-discharge.Results Compared with those of group A,FEV1(0.27±0.10) L,(0.26±0.10) L,(0.23±0.10) L,PaO2 and PaCO2 in group B,group C and group D were improved with each treament after 15 days(P0.05).There was no difference in FEV1,PaO2 and PaCO2 among group A,group B,group C and group D after post-discharge of one month(P0.05).Compared with those of group A,the score of dyspnea and the volume of sputum in group B,group C and group D decreased with each treament after 15 days and after post-discharge of one month(P0.05).On the other hand,FPG was higher in group D than in group A(8.7±2.2) mmol/L vs(9.1±2.1) mmol/L(P0.05).There was no difference among group A,group B and group C(P0.05).2 h PG was less in group A,group B and group C than in group D after each treatment of 15 days(8.7±2.2) mmol/L,(9.1±2.1) mmol/L,(9.5±2.2) mmol/L vs(10.9±2.3) mmol/L(P0.05).There was no difference of fasting insulin and 2 h insulin among the four groups after each treatment of 15 days and after post-discharge of one month(P0.05).There was less ACTH in group D than in group A,group B and group C(P0.01),but there was no difference of ACTH among the four groups after post-discharge of one month(P0.05).Conclusion The treatment with short term glucocorticosteroid on AECOPD can improve FEV1,blood gas analysis,the score of dyspnea and the volume of sputum in short period.FPG,glucose tolerance and ACTH are relevant with the time of therapy with glucocorticosteroid.The treatment with short term kata-echelon glucocorticosteroid on AECOPD does not affect FPG,glucose tolerance and ACTH.
Group B
Aminophylline
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To perform an analysis and comparative study of the clinical data for patients with cirrhosis and type 1 hepatorenal syndrome (HRS) who received treatment with terlipressin using high-or low-dose regimens.A total of 56 patients with cirrhosis and type 1 HRS who presented for treatment to the Wuhan Medical Treatment Center and Taizhou Central Hospital between March 2010 and October 2012 were enrolled in the study. The patients were randomly assigned to the terlipressin treatment groups for receipt of the high-dose regimen (1 mg/6-8 h;n =27) or low-dose regimen (1 mg/12 h;n =29). All patients were assessed for 24-hour urine volume, serum blood urea nitrogen (BUN) and creatinine (Cr) levels, therapeutic effect and prognosis, and adverse reactions. Measurements were made before and after the treatment, and on post-treatment days 3, 7 and 14. Inter-group differences were assessed by statistical analyses.The high-dose group showed an increase in 24-hour urine volumes from post-treatment day 3 (1112 ± 262 ml) to day 7 (1938 ± 312 ml), and the volumes on both days were significantly better than those of the low-dose group (day 3:986 ± 162 ml and day 7:1760 ± 300 ml, t =1.500, 1.830, P=0.038, 0.041). The high-dose group also showed a significantly better decreases in serum BUN levels (35.1 ± 8.6 to 30.2 ± 6.3 mmol/L vs.low-dose group: 43.2 ± 10.9 to 35.1 ± 7.6 mmol/L, t =3.200, 5.901, P =0.043, 0.047) and in serum Cr values (219.0 ± 35.1 to 128.2 ± 41.6 vs.low-dose group: 230.3 ± 82.1 to 151.5 ± 38.7, t =2.997, 5.765, P =0.036, 0.046).On post-treatment day 14 the 24-hour urine volume of patients in the high-dose group decreased (to 720+/-136 ml), but the difference from that of the low-dose group was not significant (vs. 620 ± 164 ml, t =1.855, P =0.069). The serum BUN level increased in the high-dose group (to 54.4 ± 15.0 mmol/L), which was statistically different from that in the low-dose group (vs .57.7 ± 17.3 mmol/L, t=5.166, P =0.022); the same trend was seen for the serum Cr value (397.8 ± 127.4 mumol/L vs. 480.3 ± 179.8 mumol/L, t =5.638, P =0.047). No statistically significant differences were observed for the groups in regard to significant efficiency, efficiency or 2-week survival rate (x2 =2.314, 1.767, 0.678, P =0.128, 0.128, 0.410 respectively), but the total efficiency was significantly different between the two groups (x² =5.793, P =0.016). In addition, no serious adverse reactions (including precordial pain, myocardial infarction or intestinal necrosis) were observed in either group.Terlipressin therapy at both high and low dosages can lead to significant beneficial effects within as little as 3 days after the treatment; however, the high-dose appears to produce a better lasting efficacy (at day 14 after the treatment). The difference in doses does not appear to markedly affect significant efficiency, efficiency, nor the 2-week survival rate.
Terlipressin
Blood urea nitrogen
Regimen
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To investigate the strategy of controlling fluid resuscitation for severe acute pancreatitis (SAP) in acute phase.From March 2001 to January 2006, 83 patients meeting for experimental criteria were included in this clinical trial. They were divided into early fluid expansion group (Group I, within 24 h after admission, 21 patients), middle fluid expansion group (Group II, within 25 - 48 h, 35 patients) and late fluid expansion group (Group III, within 49 - 72 h, 27 patients). Parameters of treatment of fluid therapy within 4 d after admission were observed. Serum lactic level was measured on admission and on meeting for criteria of fluid expansion. APACHEII scores, operation rate within 2 weeks, rate of mechanical ventilation, rate of ACS and survival rate were observed.Time interval for meeting fluid expansion criteria in Group I, Group II, Group III was (13 +/- 6) h, (38 +/- 5) h and (61 +/- 8) h, respectively. And there was statistical significance among them (P < 0.05). HCT (%) in Group I (33 +/- 6)% was lower than that of Group II (40 +/- 6)% and Group III (42 +/- 11)% significantly (P < 0.01) at the first day after admission; and there was no statistical significance between Group II and Group III. The amount of crystal and colloid infused in Group I (4014 +/- 2887) ml and (1220 +/- 705) ml at the day of admission was more than those of Group II (2366 +/- 1959) ml and (821 +/- 600) ml and Group III (2615 +/- 1574) ml and (701 +/- 585) ml (P < 0.01); but there was not different between Group II and Group III (P > 0.05). The ratio of colloid and crystal in Group III at the day of admission was lower than those of Group I and Group II (P < 0.05). The total amount of fluid infused was not different among 3 groups for the 4 d (P > 0.05). And infusion rate at the day of admission in Group I was more rapid than those of Group II and Group III (P < 0.05); and there was no difference between Group II and Group III (P > 0.05). The total amount of fluid sequestration in Group II for the 4 d was lower than those of Group I and Group III (P < 0.05); and there was no statistical significance between Group I and Group III (P > 0.05). At the first to the third day after admission APACHEII scores in Group I were higher than those of Group II and Group III (P < 0.05); and at the second and third day, APACHEII scores in Group III were higher than those of Group II (P < 0.05). Rate of mechanical ventilation in Group I (85.7%) was higher than those of Group II (37.1%) and group III (63.0%) (P < 0.05); and rate of ACS was most lowest in Group II (37.1%) (P < 0.05). Survival rate in Group I (38.1%) was lower than those of Group II (85.7%) and Group III (66.7%) (P < 0.05); and Group III was lower than that of Group II (P = 0.075).Within 72 h after onset of the disease, survival rate is improved significantly through controlling fluid resuscitation and prevention of body fluid sequestration.
Clinical Significance
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Objective
To explore the clinical effect of targeted soft channel intracranial hematoma drainage combined with urokinase and autologous serum on hypertensive cerebral hemorrhage.
Methods
Form October 2016 to October 2017, 120 patients with hypertensive cerebral hemorrhage were selected as the research objects in Handan First Hospital.In accordance with the principle of random number rule, they were divided into two groups, 60 cases in each group, the study group was given directional soft channel with autologous serum treatment, the control group was given directional soft channel joint urokinase for treatment of intracranial hematoma drainage, and then nerve function, clinical curative effect, inflammatory factors and endothelial function of two groups were compared.
Results
Before treatment, the National Institutes of HealthStroke Scale (NIHSS) score of the study group and the control group were (4.70±0.99) and (4.71±1.02), after treatment were (9.57±1.54) and (6.63±1.35), respectively.The difference between the two groups before treatment was not statistically significant (t=0.054, P=0.957). After treatment, the NIHSS scores of patients in both groups were significantly higher than those before treatment (Study group t=20.605, P=0.000, Control group t=8.790, P=0.000), The NIHSS score of the study group was significantly higher than that of the control group and the difference was statistically significant (t=11.120, P=0.000). Before treatment, Interleukin-6 (Il-6) in the study group and the control group were(45.61±4.13) ng/L and (44.98±2.19) ng/L, after treatment were (13.72±2.19) ng/L and (26.17±2.51) ng/L, respectively, and the two groups before treatment showed no significant difference (t=0.065, P=0.948). After treatment, IL-6 in both the study group and the control group decreased significantly (Study group t=52.841, P=0.000, Control group t=43.740, P=0.000), and IL-6 in the study group was significantly lower than that in the control group (t=28.951, P=0.000). Before treatment, the Tumor necrosis factor-α(TNF-α) of the study group and the control group were(63.01±4.22) μg/L and(62.96±4.21) μg/L, after treatment were(40.92±3.12) μg/L and(55.67±4.02) μg/L, respectively.The difference between the two groups before treatment was not statistically significant (t=0.065, P=0.948). TNF-α in both the study group and the control group significantly decreased after treatment (Study group t=32.604, P=0.000, Control group t=9.933, P=0.000). TNF-α in the study group was significantly lower than the control group (t=22.453, P=0.000). Before treatment, the nitric oxide of the study group and the control group were (33.46±4.27) μmol/L and(32.97±4.25) μmol/L, after treatment were(54.15±3.11) μmol/L and (43.17±3.22) μmol/L.No statistically significant difference was observed between the two groups before treatment (t=0.630, P=0.530). After treatment, nitric oxide was significantly increased in both the study group and the control group (Study group t=30.339, P=0.000, Control group t=14.818, P=0.000). Nitric oxide in the study group was significantly higher than that in the control group (t=18.999, P=0.000). Before treatment, the Endothelin-1 of the study group and the control group before and after treatment were (84.43±4.22) μg/L and (84.51±4.26) μg/L, after treatment were(57.47±5.07) μg/L and (70.14±5.12) μg/L.There was no statistically significant difference between the two groups before the treatment (t=0.335, P=0.738). After the treatment, endothelin-1 in both the study group and the control group was significantly reduced (Study group t=22.889, P=0.000, Control groupt=10.662, P=0.000), and endothelin-1 in the study group was significantly lower than that in the control group (t=9.226, P=0.000). The total effective rate of the study group after treatment was 88.33% (53/60), significantly higher than that of the control group (73.33%) (44/60). The difference between the two groups was statistically significant (χ2=4.357, P=0.037).
Conclusion
Targeted soft channel intracranial hematoma drainage combined with autologous serum was effective in the treatment of hypertensive cerebral hemorrhage, which is worthy of clinical application.
Key words:
Hypertensive; Cerebral hemorrhage; Directional soft channel intracranial hematoma drainage; Urokinase; Autologous serum
Intracranial hematoma
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Objective: To explore the effects of different methods of nutrition in nutrition status on postoperative hypertensive intra cerebral hemorrhage(HICH). Method: 196 patients with postoperative hypertensive intra cerebral hemorrhage were randomized into three groups. The group A (66 cases) enter nutrition support was started at the 2nd day after operation, growth hormone begun to be combined at the 2nd～7th day after operation. The group B (61 cases) total parenteral nutrition(TPN) was started at the 2nd day after operation . The group C (69 cases) received traditional nasal feeding. multi nutritional parameters were measured at different time. Results: The hemoglobin and albumin(Alb) of the group A was not significantly better than the group B at 21st day after operation(P 0.05), but the hemoglobin of the A group was significantly better than the those of the group C (P 0.05). The total lymphocyte count of the group A,B and C respectively at 7th, 14th and 21st day after operation was significantly better than the those of the 0 d (P 0.05). The blood glucose of the group A and C at 7th, 14th and 21st day after operation were no different better than the natural glucose numerical value (P 0.05),but the these of the group B at the same time were significantly better than the natural glucose numerical value (P 0.05). The ALT of the group A was significantly better than the group B at 21st day after operation(P 0.05), but the ALT of the A group was not significantly better than those of the C group at the same time(P 0.05). Triglyceride of the group A and C at 7th, 14th and 21st day after operation were not significantly better than the those of the 0 d (P 0.05), but the these of the group B at 21st day after operation were significantly better than the those of the 0 d (P 0.05). Conclusions: Not only can the early enter nutrition quick improve nutrition status, but also doesn't produce decompensation. It is a safe and feasible method.
Group B
Group A
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Objective
To observe the efficacy and safety of Salvianolic Acid for Injection in patients with acute cerebral infarction as well as its impact on serum levels of inflammatory factors, in order to explore new targets and new directions for drug intervention.
Methods
A prospective study was conducted to analyze 153 patients with acute cerebral infarction admitted to the Department of Neurology of the Second Hospital of Shanxi Medical University from February 2017 to March 2018. The patients were divided into either a control group (n=83) or an observation group (n=70). Both groups were treated with conventional drugs, and the observation group was additionally given Salvianolic Acid for Injection. Both groups were treated for 14 days. The neurological deficit (NIHSS scores) and inflammatory factor (sCD40L and C-reactive protein [CRP]) levels were compared between the two groups. The occurrence of adverse reactions during medications was recorded. The modified Rankin scale (mRS) scores at the 90-day follow-up were also recorded. Stepwise multivariate logistic regression was used to analyze the independent factors for good prognosis of patients with acute cerebral infarction at 90 days of discharge.
Results
After 14 days of treatment, the NIHSS score of the observation group was significantly lower than that of the control group, and the improvement rate of NIHSS score was significantly more obvious in the observation group [(2.33±1.45) vs (3.19±3.11), F=2.436, P=0.032; (0.56±0.32) vs (0.33±0.36), t=3.536, P=0.001]. At the 90-day follow-up, the mRS score of the observation group was significantly lower and the proportion of patients with a good prognosis was significantly higher than those of the control group [(0.78±1.17) vs (1.31±1.42), t=-2.522, P=0.013; 55.7%(39/70) vs 54.2%(45/83), χ2=7.021, P=0.008]. Using good prognosis as a dependent variable and including its possible influencing factors as independent variables, stepwise multivariate logistic regression analysis showed that the use of Salvianolic Acid for Injection and the improvement of neurological function were independent predictors of good prognosis in acute ischemic stroke patients at 90 days. There were no significant differences in liver function, renal function, or myocardial enzyme related test indexes between the two groups after 14 days of treatment (P>0.05). After 14 days of treatment, the levels of sCD40L were significantly lower than those before treatment in both groups [(352.06±150.69) pg/ml vs (522.63±226) pg/ml, F=2.258, P=0.001; (372.24±135.77) pg/ml vs (554.78±179.86) pg/ml, F=2.228, P=0.001]. Although the sCD40L level was lower in the observation group than in the control group after 14 days of treatment, the difference was not statistically significant (F=0.974, P=0.385). After 14 days of treatment, the CRP level of the observation group was significantly lower than that of the control group, and the degree of CRP decrease was significantly more obvious in the observation group [(2.96±1.83) mg/L vs (3.90±3.29) mg/L, F=2.045, P=0.003; (2.57±2.41) mg/L vs (1.68±1.15) mg/L, t=3.453, P=0.028].
Conclusion
Salvianolic Acid for Injection can promote the recovery of neurological function, improve clinical prognosis in patients with acute cerebral infarction, and effectively reduce the level of inflammatory factors.
Key words:
Cerebral infarction; Salvianolic Acid for Injection; Inflammatory factor; Effectiveness; Safety
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Objective To investigate the effect of Alprostadil Injection combined with Niaoduqing Granules in the treatment of chronic renal insufficiency. Methods Collecting 40 cases suffered from chronic renal insufficiency from July 2012 to February 2014 in the Authority Hospital of Jinan City, which were randomly divided into treatment(20 cases) and control(20 cases) group. Patients in the control group were po administered with Niaoduqing Granules on the basis of foundation treatment, 1 bag/time, three times daily. Patients in the treatment group were iv administered with Alprostadil Injection 10 μg/d for more than 3 h on the basis of control group. The patients in the two groups were treated for 3 weeks. After the treatment, the treatment efficacy was evaluated, while Scr, Ccr, BUN, Hb, Alb, and regulatory T cell were compared between the two groups. Results The efficacies in the treatment and control groups were 75.0% and 65.0%, respectively, and there were differences between the two groups(P 0.05). After the treatment, BUN and Scr in the two groups were significantly reduced, while the Ccr and Hb were significantly increased, and the difference was statistically significant before and after the treatment in the same group(P 0.05, 0.01). And after the treatment, BUN, Scr, and Ccr in the treatment group were improved better than those in the control group, and there was significant difference between the two groups(P 0.05). After the treatment, CD4+-Treg and CD4+CD25+CD127-Treg in the two groups were significantly reduced, and the difference was statistically significant before and after the treatment in the same group(P 0.05). And reduced degree in the treatment group was greater than that in the control group, and there was significant difference between the two groups(P 0.05, 0.01). Th1 and Th1/Th2 in the two groups were significantly increased, while Th2 was significantly reduced, and the differenc was statistically significant before and after the treatment in the same group(P 0.01). After the treatment, Th1 and Th1/Th2 in the treatment group were significantly higher than those in the control group, and there was significant difference between the two groups(P 0.05). Conclusion Alprostadil Injection combined with Niaoduqing Granules has a good clinical effect in the treatment of chronic renal insufficiency, which maybe through adjust the immune function of patients and improve the levels of Th1/Th2 to play the role.
Chronic renal insufficiency
Chronic renal failure
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