Clinical significance of changes of serum vascular endothelial growth factor level before and after radiotherapy in patients with esophageal carcinoma
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Objective To investigate the changes and clinical value of serum vascular endothelial growth factor (VEGF) level before,during and after radiotherapy in patients with esophageal carcinoma.Methods The sera of 67 esophageal carcinoma patients and 30 healthy control cases were collected.The VEGF level in serum samples were measured with enzyme-linked immunosorbent assay (ELISA) method.The relations among VEGF level changes,clinical stages and radiotherapy effect were analyzed.Results The VEGF levels of patients with esophagus cancer before,during and after radiotherapy were significantly higher than those in control group ( F =11.65,P ＜ 0.01 ).The VEGF level after radiotherapy was significant lower than that before radiotherapy ( F =10.72,P ＜ 0.01 ).The average VEGF level of patients with T3 and T4 was significantly higher than that of control group ( F =14.10,P ＜ 0.01 ).The average VEGF level of patients with N1 and N2 was significantly higher than that of control group( F =8.64,P ＜0.01).In 62 patients,the serum VEGF level increased in 21 cases but decreased in 41 cases after radiotherapy.With difference in radiotherapy efficiency of 61.90％ and 90.24％,respectively(x2 =6.08,P＜ 0.05).The average VEGF level during and after radiotherapy for 50 cases of CR + PR were significantly lower than that before radiotherapy( F =7.98,P ＜ 0.01 ).Conclusions Monitoring the serum VEGF level of patients with esophagus cancer can help evaluate the radiosensitivity,which has a significance in predicting the prognosis of radiotherapy.
Key words:
Esophageal carcinoma; Radiotherapy ; Vascular endothelial growth factorKeywords:
Radiosensitivity
Objective To study the level of vascular endothelial cell growth factor in serum of lung carcinoma patients before and after radiotherapy. Methods Serum VEGF of 40 patients with lung carcinoma and control groups were analyzed with ELISA method. Results The level of serum VEGF elevated significantly before radiotherapy in lung carcinoma patients group compared with the control. The level of VEGF of Ⅲ stage of patients were higher thanⅠⅡ stage's.but the histopathologic type were not. And the level delined in 2 week and 1 month after radiotherapy. The level of VEGF elevated significantly before and after radiotherapy in inefficienty(NR+PD) group compared with the overall immediate response rate(CR+PR), it was descended after radiotherapy, but the NR+PD group was still high level tate. Conclusion In the neartime it was curative effect for lower level of VEGF. High level state of the level of VEGF could relapse or metastasis, and it was bad curative effect in the neartime.To detect the level of serum VEGF changes in patients with lung carcinoma can help to determine the clinical stages,monitor the clinical course,curative effect and prognosis.
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AIM To investigate the breast cancer patients before and after vascular endothelial growth factor-C (VEGF-C) levels and their clinical significance. METHODS Using enzyme-linked immunosorbent assay (ELISA) determination of 64 cases of breast cancer patients before surgery, serum levels of VEGF-C change, while the control group of 30 patients measured serum VEGF-C levels. RESULTS Breast cancer patients a month serum levels of VEGF-C expression compare to preoperative, and its expression level decreased significantly and showed statistically significant difference (P<0.01). Metastasis of breast cancer patients before serum levels of VEGF-C expression tha those without metastasis, showed statistically significant difference (P<0.01). Breast cancer preoperative serum VEGF-C expression was significantly higher than the normal control group, showed statistically significant difference (P<0.01). CONCLUSION VEGF in breast cancer growth and plays an important role in the increase of serum VEGF-C show a more aggressive biological behavior.
Clinical Significance
Distant metastasis
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Objective:To observe clinical significance of the serum vascular endothelial growth factor(VEGF)before and after ra- diotherapy in patients with nasopharyngeal carcinoma(NPC).Methods:The serum VEGFof 30 healthy controls,40 patients with chronic nasopharyngotis,and 75 patients with NPC was measured by ELISA.Results:Before treatment,the serum VEGF levels in patients with NPC in stageⅢ～Ⅳwere significantly higher than those in stageⅠ～Ⅱ(P0.01).The serum VEGF levels in untreated patients and recur- rent patients were significantly higher than those in the control group and patients with chronic nasopharyngotis(P0.01).The serum VEGF levels of patients after clinical recovery were significantly lower than those in untreated patients(P0.01).Conclusion:The serum VEGF level of patients with nasopharyngeal carcinoma appears to be a new predictor for monitoring the progress and the prognosis of the disease.
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Objective To explore the serum level of vascular endothelial growth factor (VEGF) in patients with gastric cancer and its relationship with clinicopathologic characteristics and disease prognosis.Methods The level of serum VEGF was measured with sandwish enzyme linked immunosorbent assay (ELISA) in 56 patients with gastric carcinomas and 31 follow-up patients after operation,16 cases of gastric ulcer and 45 normal subjects as controls.Results The serum VEGF level in gastric carcinoma [(257.5±107.3) pg/ml] significantly elevated as compared to that in patients with gastric ulcer[(132.0±56.3 )pg/ml] and that of the normal controls[( 121.4±42.5)pg/ml],but there was no significant difference between the ulcer and healthy controls.That positive rate of serum VEGF was 69.8%, 25.0% and 11.1% in carcinoma, ulcer and normal controls,respectively. The serum VEGF level was positively correlated with tumor vessel invasion, lymph node and hepatic metastasis.The VEGF level was increased significantly with TNM stages, but not correlated with tumor size, histological type, sex and age. There was significant difference between VEGF levels in patients with recurrence and those without recurrence after surgical resection.Conclusion The serum VEGF level of gastric carcinoma appears to reflect its potential activity of vascular invasion and metastasis, and posttherapeutic VEGF may be used an indicator of recurrence and disease prognosis in gastric carcinoma.
Gastric carcinoma
Clinical Significance
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Objective To investigate the diagnostic value of serum vascular endothelial growth factor (VEGF) level for cervical cancer and its relationship with the therapeutic efficacy of concurrent chemoradiotherapy (CCRT).Methods Eighty patients with a pathologically confirmed diagnosis of advanced cervical squamous cell carcinoma (CSCC),20 patients with chronic cervicitis,and 20 healthy persons (as controls) were enrolled in the study.The CSCC patients received CCRT.All the subjects had their baseline serum VEGF levels measured by enzyme-linked immunosorbent assay (ELISA);also,the CSCC patients had their serum VEGF levels measured by ELISA at 3 months after CCRT.The relationship between the serum VEGF levels and therapeutic efficacy of CCRT was analyzed.Results The CSCC patients had a significantly higher baseline serum VEGF level than the chronic cervicitis patients and controls (237.36 μg/L vs.142.36 μg/L,t =4.03,P =0.000).The serum VEGF level was closely related to tumor stage,tumor differentiation,and lymph node metastasis.A serum VEGF level above 197.52 μg/L was the optimal cut point for diagnosing cervical cancer,with a sensitivity of 0.88 and a specificity of 0.72.The serum VEGF levels before and after CCRT showed a close relationship with the therapeutic efficacy.The patients achieving a complete remission had a significantly greater change in serum VEGF level than those with progression; the patients with high baseline serum VEGF levels had a significantly higher tumor progression or death rate than those with low baseline serum VEGF levels.Conclusions Serum VEGF level has poor diagnostic value for cervical cancer,though it is closely related to the tumor stage,tumor differentiation,and lymph node metastasis of cervical cancer.However,serum VEGF level has some predictive value for the therapeutic efficacy of CCRT in patients with cervical cancer.
Key words:
Vascular endothelial growth factor; Related; Cervical neoplasms/radiochemotherapy
Therapeutic effect
Chemoradiotherapy
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Objective
To investigate the expression of serum vascular endothelial growth factor(VEGF) in local advanced esophageal carcinoma patients, and to explore the relationship between its change rule and the recent curative effect and significance.
Methods
The serum levels of VEGF in 46 patients with local advanced esophageal carcinoma were detected by ELISA before and after concurrent chemoradiotherapy, the serum levels of VEGF in 46 healthy people were detected at the same time.
Results
The serum VEGF levels of local advanced esophageal carcinoma patients before treatment and health control group were (264.66±62.11) ng/L and (101.96±39.53) ng/L, and the difference was statistically significant (t = 23.367, P = 0.000). After treatment, the serum VEGF level of patients with esophageal cancer was decreased to (127.50±49.07) ng/L (t = 19.086, P = 0.000). After the treatment, the serum VEGF levels of complete remission (CR) and partial remission (PR) patients were decreased [(94.03±38.86) ng/L vs (248.79±47.84) ng/L, (117.06±20.68) ng/L vs(295.26±67.20) ng/L, both P = 0.000], the level of the stable disease (SD) patients was decreased, too [(235.63±26.05) ng/L vs (385.67±26.50) ng/L, P = 0.017].
Conclusions
The recent curative effects of docetaxel and nedaplatin chemotherapy combined with intensity-modulated radiotherapy for the local advanced esophageal carcinoma patients are significant. The levels of serum VEGF before and after treatment can be used as an important index to judge the treatment effect.
Key words:
Esophageal neoplasms; Drug therapy; Radiotherapy, intensity-modulated; Vascular endothelial growth factors
Nedaplatin
Chemoradiotherapy
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To explore the diagnostic value of serum vascular endothelial growth factor (VEGF) level in patients with ovarian carcinomas, and to evaluate the correlation between serum VEGF level and prognosis of ovarian cancer.Serum VEGF level in patients with ovarian neoplasms (120 cases of ovarian carcinomas, 25 cases of benign tumors) and 90 healthy women as controls was determined by enzyme linked immunosorbent assay (ELISA), also the change of preoperative and postoperative serum VEGF level of 25 cases of epithelial ovarian cancer was observed.(1)The preoperative serum VEGF levels were (766 +/- 1237) mg/L in malignant groups, and there was a significant difference compared with normal controls (55 +/- 19) mg/L or patients with benign tumor (56 +/- 23) mg/L (P < 0.05). As a cut-off at 100 mg/L, sensitivity and specificity of preoperative serum VEGF levels for diagnosing ovarian cancer was 77% and 87% respectively. (2) Serum VEGF level were significantly elevated in advanced stage (955 +/- 1716) mg/L and poorly differentiated (991 +/- 1349) mg/L compared with early stage (198 +/- 287) mg/L and well differentiated (280 +/- 552) mg/L (P < 0.05), but there is no significant difference between the VEGF level and pathological types (P > 0.05). (3) The postoperative serum VEGF levels (118 +/- 110) mg/L were significantly lower than that in preoperative (1074 +/- 1211) mg/L. (4) The average total survival-time in patients with VEGF(+) was 28 months, but it in patients with VEGF(-) was 35 months (P < 0.05).Serum VEGF values were higher in malignant tumors and preoperative serum VEGF level has a potential as a marker for diagnosing and monitoring in ovarian neoplasms.
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Objective To study the perioperative dynamic changes of serum VEGF level in non-small cell lung cancer(NSCLC)patients who undergo surgery.Methods Serum VEGF level was detected in 21 patients with NSCLC who were undergoing surgery by ELISA(enzyme linked immunosorbent assay)method before operation and on postoperative day 1,7,14,21,28.At the same time 12 patients with pulmonary benign diseases treated by surgery were studied as the control.Thirty healthy volunteers served to define normal VEGF.Results(1)Preoperative serum VEGF level(649.20 ng/L)in the group of patients with NSCLC was significantly higher compared with the benign or healthy group(respectively:140.70 ng/L and 94.40 ng/L,P=0.000).(2)Serum VEGF level was elevated after surgery and the peak was observed on postoperative day +14(1963.6 ng/L)in NSCLC,the peak was significantly higher than the preoperative level(649.20 ng/L)(P=0.000).Then the levels dropped,but it was still significantly higher than the preoperative level(P=0.000)and the level of the benign disease at the same time(P=0.000).(3)Tumor size and the differentiation were related to preoperative serum VEGF level(P0.05).Tumor size,TNM stages and lymph node metastasize correlated with the change of serum VEGF(P0.05).Conclusion Conclusions Perioperative serum VEGF level was significantly elevated in patients with NSCLC.Tumor size and the differentiation correlated with preoperative serum VEGF level.Tumor size,TNM stages and lymph node metastasis related to the change of serum VEGF.
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Objective To investigate the expression and significance of vascular endothelial growth factor (VEGF)in patients with non-small cell lung cancer(NSCLC)undergoing radiotherapy,and to explore the relationship between VEGF levels and efficacy of radiotherapy.Methods Serum level of VEGF was determined by sandwich enzyme linked immuno-adsorbent assay (ELISA)in 35 patients with NSCLC and 21 healthy controls.Results Serum level of VEGF in patients with NSCLC was significantly higher than that in controls before radiotherapy (P 0.05),and was significantly decreased after radiotherapy(P 0.05).23 cases had no recurrence 3 months after radiotherapy,and the serum level of VEGF had been restored to the normal level(P 0.05)after and 3 months after radiotherapy.10 cases had recurrence after radiotherapy,and the serum level of VEGF was significantly decreased(P 0.05),and was significantly different from that in non-relapse group(P 0.05).3 months after radiotherapy,serum level of VEGF was restored to the level before radiotherapy(P 0.05),and was significantly different from that in non-relapse group.Conclusion Serum level of VEGF is significantly increased in patients with NSCLC,and is decreased after radiotherapy,and is closely related to disease progression,which could be used as a complementary diagnostic and prognostic value of reference.
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Objective To study the clinical significance of the serum vascular endothelial growth factor(VEGF) before and after radiotherapy in patients with nasopharyngeal carcinoma(NPC). Methods The serum VEGF was measured by enzyme-linked immunosorbent assay(ELISA) in 50 healthy controls,50 patients with benign lesions of head and neck and 65 patients with NPC before and one month after treatment,and after recovery,recurrence or metastasis. Results The serum VEGF levels in untreated patients and recurrent patients were significantly higher than those in control and patients with benign lesions of head and neck group(P0.01).The serum VEGF levels of patients after clinical recovery were significantly lower than those in untreated patients(P0.01).The serum VEGF levels in recurrent patients were significantly higher than those in untreated patients(P0.01).In patients before treatment,the serum VEGF levels in NPC of stage Ⅲ-Ⅳ were significantly higher than those in NPC of stage Ⅰ-Ⅱ(P0.01). Conclusions The serum VEGF can be used as a marker of NPC for monitoring the progress and the prognosis of the disease.
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