Relationship of leptin with body mass index,triglyceride,and total cholesterol in patients with nasopharyngeal carcinoma
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Objective To investigate the correlation of serum leptin with body mass index (BMI),triglyceride(TG),and total cholesterol(TC)in patients with nasopharyngeal carcinoma. Methods A total of 50 serum specimens from patients with nasopharyngeal carcinoma and 42samples from healthy subjects were collected.Levels of leptin were detected by radioimmunoassay,so were levels of TG and TC by an automatic biochemical analyzer.BMI was determined.The data were analyzed using the SPSS software.Results BMI values and leptin levels were obviously higher in the healthy subjects than in patients with nasopharyngeal carcinoma[(23.65±3.32)kg/m2 vs.(21.12±2.86)kg/m2 and(10.205±9.319)ng/ml vs.(4.375±4.367)ng/ml;t=-3.21 P=0.002,and P ＜0.05].Leptin was positively related with BMI.TG,and TC.Conclusions Leptin levels and BMI values decrease in patients with nasopharyngeal carcinoma.Leptin is positively related with BMI,TG,and TC.
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Nasopharyngeal carcinoma; Leptin; BMI; TG; TCObjective To explore the relationship between serum leptin and blood glucose, age, blood pressure, body mass index (BMI), body fat percentage (BF%) in essential hypertension patients. Methods Serum leptin concentrations were measured by radioimmunoassay. Fasting plasma glucose (FPG), glucose area under the curve (AUC\-G), blood pressure, BMI and BF% were determined in 200 patients with 20 case with type 2 DM, 63 impaired glucose tolerance (IGT), 120 normal glucose tolerance (NGT); 81 males, 119 females. The correlation between leptin and other parameters were analyzed. Results (1) Serum leptin concentrations were significantly correlated with FPG?ACUG?age?BMI?BF%?SBP ( P 0 01～P 0 001). (2) Serum leptin concentrations were strongly correlated with BMI and BF% in both male group and female group ( P 0 001). The concentration level (μg/L) was significantly higher in DM group (17.7±9 4)than in IGT group (12 7±9 2)( P 0 05) and NGT group (10 8±6 9) ( P 0 05) The difference in serum leptin concentrations between the three groups was abolished after adjusting for BF% (3)Serum leptin concentrations were still highly correlated with BMI and BF%, when BMI and age in the three groups were matched, but not correlated to blood glucose Conclusion Serum leptin concentrations are not directly related to blood glucose, but the concentration levels are correlated with body fat percentage in essential hypertension patients.
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Objective To explore the relationship between serum leptin levels and body fat,plasma glucose ,serum lipid and insulin concentrations. Methods 85 individuals were divided into three groups according to body mass index(BMI): groupⅠ BMI23 kg/m 2(n=20),groupⅡ23 kg/m 2≤BMI25 kg/m 2 (n=18),group Ⅲ BMI≥25 kg/m 2(n=47),and fasting serum leptin,plasma glucose,plasma insulin,height,weight,percent of fat,systolic pressure,diastolic pressure,triglyceride,serum total cholesterol etc.were measured.Results (1)serum leptin levels in females were significantly higher than that in males (P0.01),and serum leptin concentrations of group Ⅲ were significantly higer than those of groupⅡand groupⅠ.(2) Fasting plasma leptin levels were positively correlated with BMI (r=0.471, P0.01),percent of fat (r=0.318,P0.01),insulin (r=0.388, P0.01),serum total cholesterol (r=0.371,P0.01), triglyceride ( r=0.491,P0.01),and systolic pressure (r=0.220, P0.05). Conclusion Hyperleptinemia and leptin resistance might be involved in the development of hyperinsulin,insulin resistance and type 2 diabete.
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Objective:To investigate the serum level of leptin between type 1 and type 2 diabetes,and its relation to the gender,body mass index(BMI),fasti ng blood glucose(FBG) and fasting insulin(FINS).Methods:Fasting serum leptin,F BG and FINS were measured simultaneously by ELISA in patients with type 1 (n=30) and type 2 diabetes (n=30). Results:The serum leptin concentrations of type 2 diabetics were higher than those of type 1 diabetics [(9.89±2.10)μg/L vs (5.06 ±1.13)μg/L,P 0.01].The significant differences of the serum leptin concentra tions were also found between females and males in tpye 1[(8.00±1.88)ng/ml vs ( 2.82±1.15)ng/ml,P 0.001]and type 2 [(16.61±3.49)ng/ml vs (2.83±0.67)ng/ml, P 0.001] diabetics.The serum leptin concentration of type 2 diabetes had a posi tive correlation with BMI (r=0.68,P 0.05) but not in type 1 diabetes group.The serum leptin concentrations of the two groups,which are not correlated with FB G,are positively correlated with fasting insulin levels(type 1 DM:r=0.32,type 2 DM:r=0.26,P 0.05). Conclusion:There is significant difference of serum le ptin between type 1 and type 2 diabetes and positive relation among serum leptin ,BMI and FINS.
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To explore the relationship between serum leptin, hypertension, body mass index (BMI) and energy metabolism.Serum leptin concentrations were measured by radioimmunoassay. Blood pressure (BMI) blood sugar (Glu), triglycerides (TG), total cholesterol (TC), LDL, HDL, BUN, Cr and Ur were determined in 64 men with essential hypertension (EHT) and 54 male normotensives (NT). The correlation between leptin and other parameters were analyzed.(1) Serum leptin concentrations n = 118 (3.3 +/- 1.9) micrograms/L in 118 subjects were significantly correlated with SBP, DBP, BMI, Glu, TG, TC and LDL(P < 0.05-P < 0.001). (2) Serum leptin concentrations were strongly correlated with BMI in both EHT and NT groups (P < 0.001). The concentration level was significantly higher in EHT group n = 64 (3.8 +/- 1.9) micrograms/L than in NT group n = 54, (2.8 +/- 1.3) micrograms/L, P < 0.01). The difference in serum leptin concentrations between the two groups disappeared when BMI and age were corrected by analysis of covariance. In NT group, serum leptin concentrations were correlated with SBP (P < 0.05). (3) If the cases of overweight, underweight, hyperglycemia, hyperglyceridemia were excluded, serum leptin concentrations were still highly correlated with BMI, but no longer related to blood pressure.Serum leptin concentrations are not directly related to blood pressure, but the concentration levels are actually correlated with the degree of obesity and energy metabolism.
Underweight
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Objective: To investigate serum leptin concentration and its relation to gender, BMI and WHR. Methods: The serum leptin concentrations were measured by RIA in 300 volunteers who came for a physical check-up. The Serum leptin (RIA assay), BMI and WHR were measured in 300 volunteers who came for a physical check-up, and they were divided into two groups according to the BMI (The control group, n=155; The obesity group, n=142). Results: The median serum leptin concentrations in the control group were 6.66 μg/L. The serum leptin concentrations in females were different from that in males (P0.001). The serum leptin concentrations in obese individual were different from that in control individuals(P0.001). In both female and male, serum leptin concentrations were linear correlated with BMI and WHR. Conclusions: Serum leptin concentrations in female were significant higher than in male; Serum leptin concentrations were significantly correlated with BMI and WHR; Serum leptin concentrations in control subjects were significantly higher than in obese subjects.
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Objective To detect the leptin levels in patients with liver cirrhosis and the relationship to their nutritional status. Methods 35 patients with liver cirrhosis (M/F: 26/9) and 30 controlled healthy subjects (M/F: 20/10) were enlisted in the study. Blood was drawn after an overnight fast. Serum leptin was measured by using a human leptin RIA kit; Other testing measurements such as blood tests to measure total protein(TP),albumin(ALB),prealbumin(PA),the height,body weight and triceps skinfold (TSF) of candidates were measured simultaneously. Body Mass index (BMI) matched body weight (kg)/[height(m)]+2. Results The mean serum levels were (6.56±3.32)ng/ml in liver cirrhosis and (4.39±2.11)ng/ml in the control group. Mean serum leptin level was significantly higher in the liver cirrhosis group than that in the control group. Compared with those in male subjects,leptin levels in female subjects increased in healthy controls and patients with liver cirrhosis. There was a significant correlation between serum leptin levels and BMI when all the subjects were evaluated together(r=0.38,P=0.015)but none in the cirrhosis group when evaluated alone (r= 0.34,P=0.11). Serum leptin levels in cirrhosis correlated significantly with TSF (r=0.61,P=0.027),no significant correlation was observed in patients between leptin and TP or ALB,or PA. Conclusion The serum leptin levels are marked higher in patients with cirrhosis. Serum Leptin correlates strongly with TSF,suggesting that serum leptin level can reflect nutritional status of the patients.
Serum Albumin
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Objective To explore the relationship between serum leptin concentrations and TG. Methods The level of serum leptin and TG was measured and analysed. Results The serum leptin concentration of different TG level groups were significantly different (F=38.426, P 0.001 ; F=30.457, P 0.001 ) between male and female. With the increasing of TG, the serum leptin concentration increased both in male group and female group (F=67.077, P0.001; F=49.786, P0.001). The serum leptin concentration of female group was significantly higher than that of male group (t= 5.057 , P0.001); the correlation coefficient of serum leptin concentration with TG level in female was 0.583 (P 0.001 ), and that in male was 0.533 (P0.001); the regression coefficient of TG in female was 1.68 (95%CI:1.09～2.26), and that in male was 0.64 (95%CI:0.40～0.88); after gender and age were adjusted, the correlation coefficient of serum leptin concentration with TG level was 0.521(P0.001). Conclusions There is significant relationship between serum leptin concentration and TG level.
Serum concentration
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To study the relationship between serum leptin level and age, sex, BMI, blood pressure, serum glucose, insulin in Chinese. Anthropometry and fasting serum leptin, glucose, insulin concentrations were measured in 146 adult Chinese. Fasting serum leptin concentrations ranged from 0 90～31 25 μg/L, with geometric mean of 7 06 μg/L. The leptin concentrations were positively correlated with BMI(r=0 363, P0 01), hip circumference(r=0 389, P0 01) and fasting insulin concentrations(r=0 343, P0 05) Serum leptin concentrations in the obese group were higher than that in the non obese group(9 85 μg/L vs 6 17 μg/L, P0 001), and higher in women than in men (10 75 μg/L vs 4 06 μg/L, P0 001) [Conclusion] Fasting serum leptin concentrations in Chinese are correlated with sex, BMI and fasting insulin concentrations. There is leptin resistance in obese subjects
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To correlate serum leptin levels in obese and non-obese type 2 diabetic patients and compare them with healthy individuals.The case-control study was conducted at the Lady Reading Hospital, Peshawar, and the Rehman Medical College, Peshawar, Pakistan, from June to November 2017, and comprised type 2 diabetic patients and and an equal number of healthy controls. Fasting blood glucose, glycated haemoglobin, serum leptin, and body mass index were assessed in obese and non-obese subjects. Relation between body mass index and serum leptin level was explored. Data was analysed using SPSS 20.Of the 96 subjects, 48(50%) were in each of the two groups. Among the cases, there were 23(48%) men and 25(52%) women with an overall mean age of 51.27±11.7 years. The control group had 28(58%) men and 20(42%) women with an overall mean age of 49.3±12.1 years. Serum leptin levels were significantly higher in obese 9.42±1.87ng/ml and non-obese 7.21±3.78 ng/ml patients than the controls 5.38±2.20 ng/ml (p<0.05). Serum leptin concentration was significantly correlated with body mass index, fasting blood glucose and BMI, FBG and glycated haemoglobin (p<0.001 each).Increased levels of serum leptin could be used as a risk factor in the development of type 2 diabetes mellitus.
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To identify the serum factors that affect circulating leptin levels, we measured the serum concentrations of leptin, testosterone (T), estradiol (E), serum alanine aminotransferase, total cholesterol and uric acid (UA) in healthy male adolescents (age, 18.3 +/- 0.1 years, n=96). We also measured body mass index (BMI), percent body fat and thickness of skin fold to assess the effect of body constitution on serum leptin level. Since serum concentration of leptin significantly correlated with BMI (r=0.820, p<0.001), we analyzed the relation-ship between leptin/BMI ratio (L/BMI) and serum parameters. Analysis of data of subjects with normal serum T level showed a significant inverse correlation between L/BMI and serum T levels (n=96, r=-0.294, p<0.005), but no such correlation was present among non-obese subjects (n=70) with BMI of +/-20% of normal (22 kg/m2). There was no correlation between L/BMI and serum E level. Serum UA level significantly correlated with L/BMI in both the test group (n=96, r=0.520, p<0.001) and non-obese subjects (r=0.369, p<0.005). Stepwise multiple regression analysis showed that UA independently and significantly influenced serum leptin levels in both the test and control groups. Our results demonstrate that T weakly influences serum leptin concentration, and that UA concentrations strongly influences serum leptin in healthy male adolescents independent of their obesity level.
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