The short term effects of topical bromfenac sodium hydrate ophthalmic solution eye drops after SMILE
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Objective To compare the efficacy and ocular safety between bromfenac sodium hydrate ophthalmic solution eye drops and topical compound tobramycin eye drops for the treatment of postoperative inflammation and the effect on intraocular pressure in subjects who had undergone small incision lenticule extraction (SMILE).Methods In a prospective,case control study,30 patients (60 eyes) were treated with bromfenac sodium hydrate ophthalmic solution eye drops 2 times daily for 2 weeks,and 30 patients (60 eyes) were treated with topical compound tobramycin eye drops 4 times daily for 1 week.All subjects had undergone SMILE surgery for myopia correction.Visual quality,intraocular pressure (IOP),corneal sensitivity,tear film break up time (BUT),Schirmer's Ⅱ test,corneal fluorescein staining and ocular surface disease index (OSDI) were assessed preoperatively and at 1 week,1 month,and 3 months postoperatively.Comparisons of the variables were performed using the repeated measures analysis of variance and multiple comparison analysis with SPSS 19.0 statistical software.Results There was no significant difference between the group treated with bromfenac sodium hydrate ophthalmic solution eye drops and the group treated with compound tobramycin eye drops when uncorrected visual acuity,best corrected visual acuity,corneal sensitivity,BUT,Schirmer's Ⅱ test,corneal fluorescein staining and OSDI were compared.The IOPcc was significantly higher in the group treated with topical compound tobramycin eye drops (15.57±2.54 mmHg) compared to the group treated with bromfenac sodium hydrate ophthalmic solution eye drops (12.51±2.45 mmHg) and the difference was statistically significant (F=45.409,P＜0.05).Conclusion Bromfenac sodium hydrate ophthalmic solution eye drops have the same anti-inflammatory effect as topical compound tobramycin eye drops and do not significantly increase IOPcc during early recovery after SMILE surgery.
Key words:
Femtosecond laser; Small incision lenticule extraction; Anti-inflammatory dgents,non-steroidal; Corneal sensitivity; Tear film break-up time; Schirmer's Ⅱ test; Corneal stainingPostoperative cystoid macular edema is an autoimmune reaction due to the blood-retinal barrier breakdown occurring at anterior segment inflammation. Aim: To analyze the effectiveness of various anti-inflammatory therapeutic schemes used in cataract surgery. Materials and methods. Phacoemulsification using similar consumables had been performed in 792 patients (932 eyes). They were divided into three groups: 1st group included patients receiving 1 to 3 dexamethasone (0.3 ml) and mesatone (0.1 ml) injections and Tobradex eye drops starting with 5 times a day for 4-5 weeks and then tapering (356 eyes); 2nd group (331 eyes) used eye drops of levofloxacin 0.5% solution and dexamethasone; and the 3rd group (325 eyes) in which instillations of ofloxacine and dexamethasone were combined with 0.09% eye drops solution of bromfenac (Broxinac) eye drops, the latter being prescribed QD for 2 days before and 16 days after surgery. Results. Treatment outcomes were less favorable in Group 1 (complications found in 15.2% of patients). Perioperative antibiotic eye drops of 0.5% levofloxacin solution provide a high level prevention of bacterial infection prevention after phacoemulsification. Patients treated with a combination of dexamethasone 0.1% solution eye drops and non-steroidal drug Broxinac had the lowest rate of postoperative inflammatory complications (7.0%).
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Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases;20 eyes).The patients in the control group were given fluorometholone eye drops,and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops.Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results:At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P 0.05). The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P 20 mmHg intraocular pressure in the control group. Conclusion:The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response,alleviate corneal irritation at early stage after CXL,effectively prevent and control the average of haze,and reduce the incidence of steroid-induced ocular hypertension after surgery.
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Purpose To evaluate the efficacy and safety of using sodium hyaluronate 0.1% and carboxymethylcellulose 0.5% artificial tears for ocular discomfort and tear-film stability in eyes after cataract surgery. Setting Twenty ophthalmic centers in Italy. Design Prospective randomized case series. Methods This study enrolled patients scheduled for unilateral cataract surgery. After surgery, patients received artificial tears and a topical steroid–antibiotic (study group) or topical steroid–antibiotic alone (control group) and were assessed postoperatively at 1 and 5 weeks. Outcome measures were tear breakup time (TBUT), ocular surface disease index (OSDI), frequency of dry-eye symptoms evaluated using a visual analog scale (VAS), and corneal fluorescein staining. Results The study comprised 282 patients. At 5 weeks, the mean TBUT was statistically significantly higher in the study group than in the control group (P = .0003). The mean OSDI score statistically significantly improved in both groups from 1 to 5 weeks (P < .0001 for both groups); however, there was no statistically significant difference between the groups at these timepoints. The artificial tears statistically significantly improved VAS-assessed dry-eye symptoms in the study group compared with the control group at 5 weeks (P < .001). The mean corneal fluorescein staining was significantly reduced in the study group compared with the control group at 5 weeks (P = .002 versus P = .05, respectively). No treatment-related adverse events were reported. Conclusion Sodium hyaluronate 0.1% and carboxymethylcellulose 0.5% ophthalmic solution was effective and well tolerated in reducing dry-eye disease symptoms and improving the clinical outcome after cataract surgery. Financial Disclosure No author has a financial or proprietary interest in any material or method mentioned.
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Objective
To observe the effects of 0.5% loteprednoletabonate/0.3% tobramycin eye drops in lamellar refractive surgery patients.
Methods
This study enrolled 158 patients, 77 cases (154 eyes) as treatment group and 81 cases (156 eyes) for control. Treatment group were treated with 0.5% loteprednoletabonate/0.3% tobramycin for 1 week, and control group with 0.1% dexamethasone/0.3% tobramycin. for 1 week.
Results
At 1 week post-surgery, the IOP 16.81±1.92 mmHg(M=17.425 mmHg)in treatment group was lower than 17.50±2.58mmHg (M=17.025 mmHg)for control(P =0.018). At 1 month, the IOP were 16.18±2.05mmHg in treatment group and 16.34±2.28mmHg for control with no difference(P =0.83). Fluorescein staining and DLK were same (P >0.05).
Conclusions
0.5% loteprednoletabonate/0.3% tobramycin. can inhibit inflammation and DLK with lower risk of IOP elevation than traditional steroids.
Key words:
Myopia; Lamellar corneal refractive surgery; SMILE; Loteprednoletabonate
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Objective To evaluate the clinical efficacy of deproteinized calf blood extract eye gel in treatment of corneal edema after cataract phacoemulsification. Methods Sixty patients( 60 eyes) with corneal edema after phacoemulsification and intraocular lens implantation were randomly divided into treatment group and control group. The treatment group received deproteinized calfblood extract eye gel,tobramycin and dexamethasone eye drops,diclofenac sodium eye drops and tropicamide eye drops. The control group received tobramycin and dexamethasone eye drops,diclofenac sodium eye drops and tropicamide eye drops. Corneal edema was observed through ophthalmic slit- lamp and the efficacy was evaluated. Results Totally sixty patients,sixty eyes were included. Thirty eyes were in treatment group and thirty ones in control group. All patients were examined and performed surgery treatment on preplanned schedule. The average paracmasis time of corneal edema in treatment group was( 6. 56 ± 2. 74) d,and( 8. 22 ± 3. 84) d in control group,there were significant difference in two groups( t =- 2. 218,P = 0. 002). Conclusion Deproteinized calfblood extract eye gel is effecitve in treatment of corneal edama after phacoemulsification.
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Objective To explore the clinical efficacy of polyethylene glycol eye drops combined with tobramycin dexamethasone ointment in treatment of meibomian gland dysfunction with dry eye.Design Retrospective comparative cases series.Participants Two hundred and thirty-eight cases(476 eyes) of meibomian gland dysfunction with dry eye.Method The participants were randomly divided into two groups: Group 1,120 patients(240 eyes) using polyethylene glycol eye drops and tobramycin dexamethasone ointment in treatment;group 2,118 cases(236 eyes) using polyethylene glycol eye drops and fusidic acid eye gel.Tear break-up time(BUT),Schirmer test(Schimer-I),corneal fluorescein staining(FL) and dry eye symptoms were recorded by questionaires and slit lamp microscope before and 2,4 weeks after medication.Main Outcome Measures BUT,Schirmer-I,FL score and dry eye symptoms.Results Before treatment,Schirmer-I,BUT,and FL score had no significant difference between group 1 and group 2(P0.05).At 2 weeks after medication,the Schirmer-I,BUT,and FL score in group 1 and group 2 was(13.6±4.2) mm and(12.5±3.8) mm(P=0.45),(12.4±3.2) s and(5.6±2.8) s(P=0.00),and(1.3±0.7) and(4.7±1.1)(P=0.00),respectively.At 4 weeks after medication,the Schirmer-I,BUT,and FL score in group 1 and group 2 was(14.7±3.7) mm and(13.4±2.5) mm(P=0.09),(14.2±2.8) s and(8.6±2.4) s(P=0.00),and(1.1±0.4) and(3.4±0.8)(P=0.00),respectively.At 2 weeks after medication,the clinical symptoms score in group 1 and group 2 was(2.6 ±0.9) and(5.4±1.5),respectively(P=0.00);at 4 weeks after medication,the clinical symptoms score in group 1 and group 2 is(1.4±0.7) and(3.8±1.3)(P=0.00).Conclusion The short-term efficacy of polyethylene glycol eye drops combined with tobramycin dexamethasone ointment for the treatment of meibomian gland dysfunction dry eye is good.
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Purpose: The aim of this study was to evaluate the efficacy of hypotonic 0.18% sodium hyaluronate (SH) eye drops under the clinical settings of the dry eye workshop treatment guideline for mild dry eye disease (DED). Methods: This analysis included 60 patients with DED. Patients with level 1 DED were treated with either isotonic 0.1% SH (group 1) or with hypotonic 0.18% SH eye drops (group 2). Patients with level 2 DED were treated with 0.1% fluorometholone, 0.05% cyclosporine A, and either isotonic 0.1% SH (group 3) or hypotonic 0.18% SH (group 4) eye drops. Tear film breakup time (TBUT), Schirmer test, corneal staining with fluorescein, and ocular surface disease index score were recorded at baseline, 1 month, and 3 months after treatment. Results: In group 2, TBUT at 3 months (P = 0.03) and corneal staining scores at 1 and 3 months (P ≤ 0.03) were significantly improved after the treatment compared with baseline scores, whereas these parameters were not changed during the follow-up period in group 1. In groups 3 and 4, TBUT and corneal staining scores at 1 and 3 months, and ocular surface disease index score and Schirmer test results at 3 months after the treatment showed significant improvements compared with the baseline score (P < 0.05). Group 4 patients showed an extended TBUT and an improved corneal staining score (P ≤ 0.01) at 3 months after treatment, compared with the values of group 3. Conclusions: Hypotonic 0.18% SH eye drops seemed to be effective in improving tear film stability and ocular surface integrity compared with isotonic 0.1% SH eye drops in patients with mild DED.
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Abstract Purpose Prospective, randomised, open-label, comparative study to evaluate efficacy of trehalose/sodium hyaluronate eye drops for post-operative discomfort and tear film stability in patients undergoing cataract surgery. Methods Patients with healthy ocular surface, subclinical, or mild dry eye were enrolled. Tear breakup time (TBUT), Schirmer test, dry eye symptoms, corneal fluorescein staining (CFS), and ocular surface disease (OSDI) evaluation were performed pre-operatively and at two and four weeks after surgery. Patients were assigned to receive trehalose/sodium hyaluronate eye drops b.i.d (Group A), or 0.9% unpreserved sodium chloride eye drops b.i.d for 4 weeks (Group B). Results One hundred and thirty-five patients were randomised, 66 patients in Group A (73.2 ± 4.5 years) and 69 patients in Group B (74.3 ± 3.8 years), 60.8% females. Fifteen patients (8 Group A) were lost at follow-up. Pre-operatively, no between-group differences were observed, and TBUT increased in Group A between the pre-operative and 2 and 4 week evaluations and was higher in group A than in Group B at 4 weeks. Schirmer test and CFS showed an improvement only in Group A four weeks post-operatively. In Group A an improvement was observed after two and four weeks in foreign body and puncture sensation, whilst a difference in blinking discomfort was observed after four weeks. In Group B we observed an improvement in puncture sensation two and four weeks after surgery. Mean OSDI scores differences between the two groups were significant at four weeks. Conclusions Trehalose/sodium hyaluronate eye drops were effective in reducing signs and symptoms of dry eye and improving tear film stability
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Subclinical infection
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To evaluate the clinical efficiency of the treatment of dry eye disease (DED) with ocular pain using deproteinized calf blood extract (DCBE) eye drops as compared to 0.3% sodium hyaluronate (SH) eye drops.This prospective, single-center, masked (double-blind), randomized controlled study included 53 patients divided into two groups: DCBE (n=22) and SH (n=31) group. The DCBE group received DCBE eye drops for 4 weeks, and the SH group received 0.3% SH eye drops for 4 weeks. Corneal fluorescein staining (CFS) scores, tear break up time (TBUT), Schirmer test and the ocular surface disease index (OSDI) scores were evaluated in all patients before treatment, 2 and 4 weeks post-treatment.The DCBE group showed better improvement in the OSDI light sensitivity scores and ocular pain scores compared with the SH group (P<0.05). At 2 and 4 weeks post-treatment, the DCBE group and the SH group showed significant improvement in TBUT, Schirmer test, CFS, OSDI score, light sensitivity score and ocular pain score (P<0.05) compared with the data from before treatment.This study indicates that DCBE eye drops can relieve ocular pain and light sensitivity in dry eye patients better than SH eye drops.
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Objective To investigate the effects of combined with antibiotic eye drops and non-steroidal anti-inflammatory drugs eye drops after cataract surgery,then further study its safety and effectiveness after phacoemulsification.Methods One hundred and eighty cataract patients without complications were divided into three groups randomly: A group: used tobramycin dexamethasone eye drops after phacoemulsification.B group: used tobramycin dexamethasone eye drops and pranoprofen eye drops after phacoemulsification.C group: used gatifloxacin eye drops and pranoprofen eye drops after phacoemulsification.Then measured intraocular pressure at 3 days,7days and 14 days after phacoemulsification.The results were showed by means plus or subtracting standard,the groups means was compared by one-way aonva,the deviation of between groups means was compared by Student-Newman-Keuls.The difference of P0.05 had statistical significance.Results The intraocular pressure was significantly elevated in A group and B group compared with C group(P0.01).The intraocular pressure was significantly reduced in B group compared with A group at 3 days,7days and 14 days after phacoemulsification(P0.05).Conclusion To combine with gatifloxacin eye drops and pranoprofen eye drops was safety and effectiveness.It may be used to treat cataract patients after phacoemulsification.
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