Captopril (sq 14,225) Induced Pityriasis Is Rosea Like Eruption.
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Abstract:
A cam is reported in which p rosealike lesions appeared with captopril, a new an!lypertmgvc drug.Keywords:
Pityriasis rosea
Captopril
Pityriasis
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Pityriasis rosea
Vitiligo
Pityriasis
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Background and objectives: The aim of this study was to measure the rate of a typical cases of pityriasis rosea among dermatological visit and to outline the various clinical presentations of a typical pityriasis rosea disease. Methods: This descriptive study was conducted for a period extended from October 2007 through June 2008. 88 patients who diagnosed to have pityriasis rosea were enrolled in this study. The diagnosis was based on history and clinical examination; questionnaire was designed to provide relative data and all patients’ data were recorded at time of diagnosis. Investigations in certain cases were done to aid in the diagnosis. Results: A typical pityriasis rosea was found in 38.5% patients. Absence of herald patch in 17% of patients, papular rosea in 8%, inverse pityriasis rosea in 6.8%, localized pityriasis rosea in 4.5%, unilateral/inverse in 1.1% and urticarial in 1.1% of patients Conclusion: A typical pityriasis rosea is not uncommon and different forms of a typical pityriasis rosea exist. Investigations are sometimes needed to confirm the diagnosis.
Pityriasis rosea
Venereology
Pityriasis
Clinical Diagnosis
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Pityriasis rosea
Pityriasis
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Pityriasis rosea is one of the commonly encountered papulo squamous disease in dermatology outpatient department. Its clinical presentations are varied, and it also has many atypical forms. We report a case of a male patient with classical Pityriasis rosea lesions limited to the patches of Hansen's disease. This is probably being reported for the first time in literature.
Pityriasis rosea
Pityriasis
Outpatient clinic
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Pityriasis rosea
Acantholysis
Pityriasis
Hailey–Hailey disease
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Pityriasis rosea
Seborrheic Dermatitis
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Pityriasis rubra pilaris
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Captopril, an oral active dipeptidylcarboxypeptidase inhibitor with antihypertensive properties, has been reported to have the following cutaneous side effects: macular and papular skin eruptions, urticaria, angioedema, mouth ulcers, pemphigus, and pityriasis rosea-like eruptions. Here, to the best of our knowledge, is the first case in which a pityriasis rosea-like eruption evolved into a lichenoid drug eruption. Also discussed is the remarkable similarity in the side effects of captopril, gold compounds, d-penicillamine, and organic mercurials.
Captopril
Pityriasis rosea
Drug eruption
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Pityriasis rosea is a skin disease characterized by sharply defined pruritic red patches covered by fine scales. It affects mostly adolescent and young adults. Typical lesions usually affect the trunk in a Christmas-tree pattern. The eruption usually resolves after 6 weeks but symptomatic treatment may be needed. Two patients are reported with classic presentation of pityriasis rosea except for the unusual associated palmoplantar lesions; both patients had negative RPR (with dilutions) and MHA-TP. They responded to 2-week courses of either oral erythromycin or Clarithromycin with complete resolution.
Pityriasis rosea
Pityriasis
Palmoplantar pustulosis
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Scaling is an elementary lesion of the skin, that follows an erythema persisting for some days. Scaling is due to an accelerated reproduction of the epidermal cells, which is caused by the vasodilatation of the papillary plexus characterizing erythema. Scaling may be observed during the remission phase of numerous skin diseases, from actinic erythema to exanthemata. On the other hand, in erythematous and scaling skin disorders, desquamation is an important component precociously superimposed to intensely erythematous patches. In this chapter we will treat pityriasis rosea, eczematides, pityriasis lichenoides, patch parapsoriasis and psoriasis. We will not talk about pityriasis versicolor, which is very rare in childhood. Even patch parapsorias does not practically exist in the first decade, but some cases may occur in the second decade. Psoriasis is slightly less frequent in children as compared with adults. Pityriasis rosea and pityriasis lichenoides affect the same age group. They are rare before the third year and after the third decade. Eczematides are more frequent in children than in adults.
Pityriasis rosea
Pityriasis
Erythema
Desquamation
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• Captopril, an orally active dipeptidylcarboxypeptidase inhibitor, is a promising new antihypertensive agent. Cutaneous reactions, including (rarely) a pityriasis rosea-like eruption, are frequently associated with this therapy. Two new cases of a pityriasis rosea-like captopril-induced eruption support a pharmacologic mechanism for the eruption, since it resolved after the dosage of captopril was lowered in one patient and continued when the dosage of captopril remained unchanged in the other patient. However, the eruption later responded to therapy while use of the drug was continued. Captopril should be included among those drugs associated with a pityriasis rosea-like eruption. (Arch Dermatol1982;118:186-187)
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Captopril
Pityriasis
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