IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia
Chunhua SongZheng GeYali DingBi‐Hua TanDhimant DesaiKrishne GowdaShantu AminRaghavendra GowdaGavin P. RobertsonFeng YueSuming HuangVladimir S. SpiegelmanJonathon L. PayneMark E. ReevesZafer GürelSoumya IyerPavan Kumar DhanyamrajuMeixian XiangYuka Imamura KawasawaNathália Moreno CuryJosé Andres YunesMary McGrathJoseph SchrammRuijun SuYiping YangZhijun ZhaoXiaoguang LyuMarkus MüschenKimberly J. PayneChandrika GowdaSinisa Dovat
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MCL1
Histone deacetylase inhibitor
Since the first mouse clone was produced by somatic cell nuclear transfer, the success rate of cloning in mice has been extremely low. Some histone deacetylase inhibitors, such as trichostatin A and scriptaid, have improved the full-term development of mouse clones significantly, but the mechanisms allowing for this are unclear. Here, we found that two other specific inhibitors, suberoylanilide hydroxamic acid and oxamflatin, could also reduce the rate of apoptosis in blastocysts, improve the full-term development of cloned mice, and increase establishment of nuclear transfer-generated embryonic stem cell lines significantly without leading to obvious abnormalities. However, another inhibitor, valproic acid, could not improve cloning efficiency. Suberoylanilide hydroxamic acid, oxamflatin, trichostatin A, and scriptaid are inhibitors for classes I and IIa/b histone deacetylase, whereas valproic acid is an inhibitor for classes I and IIa, suggesting that inhibiting class IIb histone deacetylase is an important step for reprogramming mouse cloning efficiency.
Trichostatin A
Histone deacetylase inhibitor
Cloning (programming)
HDAC11
Hydroxamic acid
Valproic Acid
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Supplementary Figures 1-2 from Histone Deacetylase Inhibitor–Mediated Radiosensitization of Human Cancer Cells: Class Differences and the Potential Influence of p53
Histone deacetylase inhibitor
HDAC11
Histone deacetylase 5
HDAC10
Histone deacetylase 2
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Histone deacetylase inhibitor
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Supplementary Figures 1-2 from Histone Deacetylase Inhibitor–Mediated Radiosensitization of Human Cancer Cells: Class Differences and the Potential Influence of p53
Histone deacetylase inhibitor
HDAC11
Histone deacetylase 5
HDAC10
Histone deacetylase 2
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Histone deacetylase inhibitor
Histone deacetylase 5
HDAC11
Histone deacetylase 2
HDAC10
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Leukemia threatens children's health, and leukemia cell proliferation and apoptosis participate in the regulation of leukemia. The current study aims to probe into the miR-125b-5p biological function in regulating leukemia cell proliferation and apoptosis by myeloid cell leukemia 1 (MCL1). Quantitative real-time polymerase chain reaction was conducted to quantify miR-125b-5p expression in leukemia cells. Cell transfection, cell-counting assay 8, Western blot, and flow cytometry assays were applied to assess the miR-125b-5p function in leukemia. A dual-luciferase reporter gene assay was applied to investigate the mechanism. miR-125b-5p was lessened in leukemia cells, and the increased miR-125b-5p repressed leukemia cell proliferation and boosted apoptosis. Further, miR-125b-5p could bound with the MCL1 3'-untranslated region and regulated its expression. Furthermore, the elevated expression of miR-125b-5p repressed leukemia cell proliferation and boosted apoptosis through downregulating MCL1. miR-125b-5p inhibited leukemia cell proliferation and boosted apoptosis through decreasing MCL1.
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In this issue, Smith and colleagues demonstrate the antitumor effects of entinostat in an ovarian cancer model and reveal how the drug effects are mediated by the immune system. These studies finally have the potential to translate the unique activity of histone deacetylase inhibitors to solid tumors.
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Valproic Acid
Trichostatin A
Histone deacetylase inhibitor
Histone deacetylase 5
Histone deacetylase 2
HDAC10
HDAC11
Chaperone (clinical)
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Supplementary Figures 1-8 from Deciphering the Molecular Events Necessary for Synergistic Tumor Cell Apoptosis Mediated by the Histone Deacetylase Inhibitor Vorinostat and the BH3 Mimetic ABT-737
Vorinostat
Histone deacetylase inhibitor
HDAC11
Histone deacetylase 5
Histone deacetylase 2
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