Digestive fate of polyphenols: updated view of the influence of chemical structure and the presence of cell wall material
71
Citation
68
Reference
10
Related Paper
Citation Trend
Keywords:
Health Benefits
Digestive tract
Health Benefits
Cite
Citations (4)
Cereal grains are important sources of dietary polyphenols, which contribute greatly to people's health. In this part, after a brief introduction of rice polyphenols, the extraction methods, as well as the components of rice polyphenols, are introduced and then the health benefits such as antioxidant, anti-obesity, and anti-cancer activity were discussed, after that, the future application of rice polyphenols are looked into the distance.
Health Benefits
Identification
Cite
Citations (0)
Caco-2
Cite
Citations (20)
Interest in the physiological role of the bioactive compounds present in plants has increased dramatically over the last decade. Of particular interest in relation to human health are the class of compounds known as the phytoestrogens, which embody several groups of non-steroidal oestrogens including isoflavones, lignans and stilbenes that are widely distributed within the plant kingdom. These compounds have a wide range of hormonal and non-hormonal activities in animals or in vitro and these suggest plausible mechanisms for potential health effects of diets rich in these compounds in humans. In addition, experimental and epidemiological data are available to support the concept that phytoestrogen-rich diets exert physiological effects, and preliminary human studies suggest a potential role for dietary phytoestrogens in affecting hormone-dependent disease rates. © 2000 Society of Chemical Industry
Health Benefits
Cite
Citations (310)
Polyphenols are a diverse group of naturally occurring compounds that are widely distributed in plant-based foods such as fruits, vegetables, nuts, grains, and spices. This chapter provides a glimpse into the fascinating world of food polyphenols and their potential health benefits. However, polyphenols can be broadly classified into four major groups: phenolic acids, flavonoids, phenolic amides, and other polyphenols. The health benefits of dietary polyphenols are mainly anti-inflammatory, antioxidant, and antiproliferative, or they follow epigenetic regulation. The mechanisms of action of polyphenols involve their ability to bind to enzymes and modulate them, acting as free radical scavengers that prevent the formation of reactive oxygen species or remove them before they damaging vital components of the cell. Research into the microbiome pathway is ongoing, and scientists are working to better understand how these microorganisms interact with their hosts and how these interactions can be manipulated to improve health outcomes.
Health Benefits
Cite
Citations (1)
This chapter contains sections titled: Introduction Oral Bioavailability Definition Cassette Dosing Across-species Prediction of Bioavailability In silico Models for Estimating Human Oral Bioavailability Quantitative Structure–Activity Relationship (QSAR) Approaches Molecular Properties Influencing Bioavailability Estimation of Bioavailability from Calculated Absorption ACE Inhibitors β-Blockers Calcium Antagonists In vitro Model for Predicting Oral Bioavailability in Human and other Species In vivo Method for Estimating Human Oral Bioavailability from Animal Pharmacokinetic Studies Factors to Consider in Optimizing Oral Bioavailability
Cite
Citations (2)
Health Benefits
Human nutrition
Human studies
Cite
Citations (16)
Abstract There is an urgent need to improve human diet globally. Compelling evidence gathered over the past several decades suggests that a suboptimal diet is associated with many chronic diseases and may be responsible for more deaths than any other risks worldwide. The main components in our diet that need higher intake are whole grains, fruit and vegetables, and nuts and seeds; all of these are important sources of dietary fiber and polyphenols. The health benefits of dietary fiber and polyphenols are also supported by several decades of valuable research. However, the conclusions drawn from interventional human trials are not straightforward and the action mechanisms in improving human health are not fully understood. Moreover, there is a great inter‐individual variation caused by different individual capabilities of processing, absorbing and using these compounds effectively. Data on the bioavailability and bioefficacy of hydroxycinnamic acids (HCAs) are limited when compared to other classes of polyphenols (e.g. anthocyanins). This review aims to summarize the latest research advances related to HCA bioavailability and their biological effects revealed by epidemiological data, pre‐clinical and clinical studies. Moreover, we aim to review the effects of HCAs on gut microbiota diversity and function and its respective influence on host health. © 2019 Society of Chemical Industry
Health Benefits
Human studies
Cite
Citations (116)
The purpose of this mini-symposium is to present current information on the ways that polyphenols, found in popular food and beverages, may affect exercise and health. Polyphenolic compounds are ubiquitous in plant foods, and a significant quantity is consumed in our daily diet. Antioxidant activities of polyphenols have been recognized for decades, and research and development on the use of natural substances or food ingredients containing polyphenolic antioxidants is of great interest to the food and health industry. The most important biological activity of polyphenols is probably their many observed inhibitory effects on carcinogenesis. We will discuss in detail the polyphenolic antioxidants and health benefits of green tea and herbs. Tannins are high molecular weight polyphenols, known for their ability to bind and precipitate proteins as well as chelate transition metals. The potential for tannins to contribute to antioxidant protection will be addressed. Scientific information concerning isoflavonoids use as a nutritional derived antiatherosclerotic and antioxidant will be presented.
Health Benefits
Cardiovascular Health
Functional food
Cite
Citations (0)
Polyphenols are widely known for their benefits to human health; however, dietary intake of this class of compounds is low in the United States due to low intake of fruits and vegetables. Dairy foods (i.e., milk, yogurt) have been shown to increase polyphenol bioavailability via protein-polyphenol interactions, which may have important implications for human health. Increasing consumer interest in sustainability and health has led to the introduction of a variety of novel plant-based proteins and related food products as dairy alternatives. This study compared whey, a popular dairy-based food protein, to pea and hemp proteins for their abilities to form complexes with polyphenols from blueberries, which are a widely consumed fruit in the US with demonstrated health effects. Physical and chemical characteristics of each protein extract in the presence and absence of blueberry polyphenols were investigated using a variety of spectroscopic methods. The influence of polyphenol complexation on protein digestion was also assessed in vitro. While all proteins formed complexes with blueberry polyphenols, the hemp and pea proteins demonstrated greater polyphenol binding affinities than whey, which may be due to observed differences in protein secondary structure. Polyphenol addition did not affect the digestion of any protein studied. Solution pH appeared to play a role in protein-polyphenol complex formation, which suggests that the effects observed in this model food system may differ from food systems designed to mimic other food products, such as plant-based yogurts. This study provides a foundation for exploring the effects of plant-based proteins on phytochemical functionality in complex, "whole food" matrices, and supports the development of plant-based dairy analogs aimed at increasing polyphenol stability and bioavailability.
Health Benefits
Digestion
Nutraceutical
Phytochemical
Rice protein
Cite
Citations (14)