Home treatment with intravenous enzyme replacement therapy for Gaucher disease: an international collaborative study of 33 patients
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Intravenous infusions were first given soon after Harvey’s demonstration of the circulation of the blood, in the seventeenth century. At that time infections, the opposition of the church, and severe reactions discouraged their continued use. In 1891, Matas reported the use of 250 to 1500 cc. normal saline intravenous infusions in cases of severe shock and hemorrhage. In 1905, Mummery recommended intravenous saline with small amounts of adrenalin in surgical shock, with the idea of raising the blood pressure by diluting and increasing the quantity of circulating fluid. Matas, in 1924, advised continuous dextrose intravenous infusions in certain surgical conditions for the nutritive value of the dextrose and. because of the danger of salt retention with saline. Since the 1920’s the use of intravenous salt and sugar solutions has become more and more common. At the Robert Packer Hospital, shortly before the World War, large quantities of intravenous fluids were given as diluents for salvarsan. In 1918, two patients in adjacent beds each received more than 70 injections. In 1930, the number of intravenous injections increased markedly and, during the month of March 1940, ten or eleven patients daily received one or more intravenous injections.
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Objective:To compare the effects of the two different types intravenous needles in the intravenous infusion of the old inpatients.Methods:Both of the Type 7 and 5.5 intravenous needles were used in 136 old patients in hospital who received intravenous infusion therapy in two days.Compare the success rate of intravenous injection and pain while using the two types of intravenous needles in the old inpatients.Results:The success rate of intravenous injection while using Type 5.5 intravenous needles was higher than that of Type 7 intravenous needles (p0.05).The pain of intravenous injection while using Type 5.5 intravenous needles was less than that of Type 7 intravenous needles (p0.05).Conclusion:The application of Type 5.5 intravenous needles to the intravenous infusion of the old inpatients would help improve nursing quality and reduce the issue about the intravenous infusion between nurses and patients.
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Objective To explore the status quo of nursing on intravenous infusion therapy at home and in abroad.Methods It introduced the usage of intravenous infusion tools , the teams and occupational protection of intravenous infusion therapy , aim to understand the status quo of the development of intravenous infusion therapy.Results Many new intravenous infusion tools appeared constantly in clini-cal.Many hospitals had their intravenous infusion therapy teams and paid more attention to training of specialist nurses , but problems still ex-isted in chemotherapy safety , many nurses did not aware of the dangers of the chemotherapy drug.Conclusions Positive measures shoud be taken to promote the professional development of intravenous infusion therapy.
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markdownabstract__Abstract__
Pompe disease is a metabolic myopathy. Since the first description of the disease
in 1932 by J.C. Pompe,1 tremendous progress has been made from discovering the
biochemical and genetic basis of the disease to developing enzyme replacement
therapy (ERT).
With this therapy, the management of Pompe disease has moved from supportive
care alone, to a disease-specific intervention aimed at correcting the underlying
enzymatic defect. While in the past research mainly concentrated on elucidating
the biochemical pathways and pathophysiology of Pompe disease, nowadays focus
has shifted towards documenting the natural history of the disease and studying
the effect of the new treatment.
A structured follow-up of a large number of patients is difficult in a rare disorder
like Pompe disease. The establishment of an expert center for Pompe disease at
the Erasmus MC University Medical Center has helped us to systematically study
all Pompe patients living in the Netherlands. At present, we follow 149 patients,
of which 18 patients are diagnosed with classic-infantile Pompe disease; and 20
children and 111 adults with less progressive forms of the disease.
The studies in this thesis have focused on children with Pompe disease. Our aim
was to delineate the first presentation and clinical characteristics of the disease and
to study the long-term effects of enzyme replacement therapy with recombinant
human alpha-glucosidase.
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Foundations of intravenous infusion therapy practice: introduction to intravenous infusion therapy fluid and electrolyte fundamentals related to intravenous infusion therapy the legal implications of intravenous infusion therapy infection control related to intravenous infusion therapy. The practice of intravenous infusion therapy: risks, complications, and adverse reactions associated with intravenous infusion therapy intravenous infusion preparations patient preparation and site selection for peripheral intravenous infusion therapy equipment and supplies employed in the preparation and administration of intravenous infusion therapy the delivery, care, maintenance, and discontinuation of intravenous infusion therapy mathematical calculations for the administration and maintenance of intravenous infusion therapy pharmacologic principles related to the preparation and administration of intravenous medications centrally placed vascular access devices and advanced medications delivery systems intravenous nutritional support blood and blood product administration. Intravenous infusion needs of the paediatric and gerontology populations: intravenous infusion therapy for the paediatric patient intravenous therapy for the elderly patient.
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