Long-term corrosion resistance and fast mineralization behavior of micro-nano hydroxyapatite coated magnesium alloy in vitro
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The Mg-6%Zn-5%Hydroxyapatite (HA) biomaterial had been prepared through powder metallurgy method in this investigation. The mechanical properties and biodegradable behaviors of the Mg-Zn-HA composite in simulated body fluid were studied. The Mg-Zn-HA specimens obtained appropriate density, adjustable elastic modulus and compatible strength to natural bones. Immersion corrosion experiments revealed that 5wt% addition of HA in Mg-6%Zn alloy exhibited acceptable corrosion rates in simulated body fluid. The Mg matrix, Mg 7 Zn 3 phase and HA are identified in the experimental composite. The Mg(OH) 2 and Hydroxyapatite were found on the corrosion products in the simulated body fluid.
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Two-layer hydroxyapatite film was prepared on WE43 magnesium alloy surface by electrochemical deposition method.XRD results showed that the film consisted of flake-like CaHPO_4·2H_2O and spindle hydroxyapatite after pretreatment,and the film consisted of spindle hydroxyapatite and Ca(OH)_2 after hot dip process.Polarization curves showed that the compact hydroxyapatite film could improve the corrosion resistance of WE43 magnesium alloy significantly when immered in simulated body fluid(SBF).Ca(OH)_2 was generated due to the relatively high concentration of hot 0.5 mol/L NaOH in the solution.
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Due to the combination of many unique properties, magnesium alloys have been widely recognized as suitable metallic materials for fabricating degradable biomedical implants. However, the extremely high degradation kinetics of magnesium alloys in the physiological environment have hindered their clinical applications. This paper reports for the first time the use of a novel microwave-assisted coating process to deposit magnesium phosphate (MgP) coatings on the Mg alloy AZ31 and improve its in vitro corrosion resistance. Newberyite and trimagnesium phosphate hydrate (TMP) layers with distinct features were fabricated at various processing times and temperatures. Subsequently, the corrosion resistance, degradation behavior, bioactivity and cytocompatibility of the MgP coated AZ31 samples were investigated. The potentiodynamic polarization tests reveal that the corrosion current density of the AZ31 magnesium alloy in simulated body fluid (SBF) is significantly suppressed by the deposited MgP coatings. Additionally, it is seen that MgP coatings remarkably reduced the mass loss of the AZ31 alloy after immersion in SBF for two weeks and promoted precipitation of apatite particles. The high viability of preosteoblast cells cultured with extracts of coated samples indicates that the MgP coatings can improve the cytocompatibility of the AZ31 alloy. These attractive results suggest that MgP coatings, serving as the protective and bioactive layer, can enhance the corrosion resistance and biological response of magnesium alloys.
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