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    Intralesional Triamcinolone May Not Be Beneficial for Treating Acute Hidradenitis Suppurativa Lesions: A Double-Blind, Randomized, Placebo-Controlled Trial
    Dermatologic Surgery (2019)
    Kristen FajgenbaumLauren CrouseDong LiDonglin ZengChristopher J. Sayed
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    Abstract:
    Hidradenitis suppurativa (HS) is a chronic, inflammatory condition characterized by recurrent nodules, sinus tracts, comedones, and scarring. Hidradenitis suppurativa is often associated with pain and decreased quality of life. Limited clinical trial data exist regarding the management of acute HS lesions, but clinical experience and a prospective case series suggest that intralesional triamcinolone may be useful.To compare the efficacy of intralesional triamcinolone to placebo for the treatment of HS inflammatory lesions.This is a double-blind, randomized, placebo-controlled trial comparing intralesional triamcinolone 10 mg/mL, triamcinolone 40 mg/mL, and normal saline (NS). Thirty-two subjects at University of North Carolina Dermatology and Skin Cancer Centers were enrolled for a total of 67 lesions. Subjects reported pain scores, days to resolution, and satisfaction on a standardized survey over a 14-day period.When intralesional injections of triamcinolone 10 mg/mL, triamcinolone 40 mg/mL, and NS were compared, no significant difference was found for days to HS inflammatory lesion clearance, pain reduction at Day 5, or patient satisfaction.No statistically significant difference was found between varying concentrations of triamcinolone and NS for the treatment of HS lesions. Steroid injections may be less effective for the management of acute HS than typically presumed.
    Keywords:
    Hidradenitis Suppurativa
    Topics:
    Hidradenitis Suppurativa and Treatments
    Colorectal and Anal Carcinomas
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    American Journal of Ophthalmology (1982)
    Reinhardt H. SchindlerDavid ChandlerRandy ThresherRobert Machemer
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    Edmund ApplebaumAustin H. KutscherEdward V. ZegarelliHenry P. Levy
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    Ahmed Abdelfattah
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    Austin H. KutscherEdward V. ZegarelliHerbert F. SilversJohn D. Piro
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    British Journal of Diseases of the Chest (1979)
    M. PeakeR.M. CaytonP Howard
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    Effect of massive dosage of a new corticosteroid, triamcinolone acetonide, on the hard and soft tissues of the oral cavity in the normal monkey
    Oral Surgery Oral Medicine Oral Pathology (1961)
    Edmund ApplebaumAustin H. KutscherEdward V. ZegarelliHenry P. Levy
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    Frozen shoulder syndrome: comparison of oral route corticosteroid and intra-articular corticosteroid injection.
    PubMed (2004)
    M Widiastuti-SamektoGoldfrted P Sianturi
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