Cadmium disrupts the DNA damage response by destabilizing RNF168
Shuyuan ZhangShuailin HaoZhiyu QiuYa WangYuqin ZhaoYouhang LiWen GaoYan WuChang LiuXingzhi XuHailong Wang
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The influence of optimum (0.6%), excessive (2.4%) and insufficient calcium content in the ration on the course of cadmium poisoning was studied in a chronic experiment on rats. Cadmium poisoning was drastically exaggerated in the presence of insufficient cadmium content in the ration of the animals, while the excessive calcium content produced a protective effect on the animals suffering from chronic cadmium poisoning.
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Cadmium is a heavy metal found naturally in the environment that has been associated with negative health outcomes. The present study examines levels of blood cadmium (BCd), urinary cadmium (UCd), and the main sources of cadmium exposure among Canadians aged 20 to 79.The data are from cycles 1 (2007 to 2009) and 2 (2009 to 2011) of the Canadian Health Measures Survey (CHMS), including measures of BCd and UCd, markers of smoking status (self-reported and second-hand smoke exposure), and self-reported consumption of foods known to be high in cadmium. The relationship between sources of exposure and cadmium levels was examined descriptively. The magnitude of the contribution of different exposure sources was examined in regression models.Age and smoking status were the greatest contributors to BCd and UCd: older people and current smokers had the highest cadmium levels. Dietary exposure, while significant, was a modest contributor overall, but a more important source of cadmium among never-smokers.Smoking was the greatest contributor to cadmium levels among Canadians aged 20 to 79. Dietary differences explained a small percentage of variation in cadmium levels.
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Objective To observe subchronic
cadmium-induced liver and kidney injury,and to study the relationship between
Metallothionein(MT)and cadmium toxicity. Methods 0.5mg/kg Cd2+ as CdCl2 solution was
injected intraperitoneally,3 times/week,and the functions of liver and kidney were detected
dynamically in 10 weeks of cadmium exposure. Results After 6-week cadmium exposure,the
injury of liver and kidney was observed functionally and morphologically,and the mole ratio of
Cd over MT in corresponding tissue was greater than 7. The severity of cadmium-induced
damage increased with the increase of CdMT ratio. Conclusion Both liver and kidney are
targets of subchronic cadmium exposure,and non-MT-bound cadmium may be an important
component in cadmium pathogenesis.
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Abstract • Mortality was observed in 4- to 5-week-old Swiss Webster mice exposed to 300 or 3 ppm cadmium as cadmium chloride in the drinking water. Mice receiving 300 ppm cadium suffered 26% mortality as compared with 7% of those on the low cadmium dose. Death did not occur in control mice. Clinical signs and histopathology established Hexamita muris as the causative agent. Cadmium lesions were not observed. It is suggested that mortality due to hexamitiasis resulted from synergism between cadmium and H muris.
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Chronic cadmium poisoning occurs after prolonged exposure to the dust or fumes of cadmium-containing compounds. This paper describes the case of a pigment worker exposed to cadmium carbonate dust who exhibited many of the characteristic features of chronic cadmium poisoning.
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Cadmium is a dangerous occupational and environmental toxin. It accumulates in the human organism mainly in liver and kidneys. Cadmium half-life is about 10 years, so the symptoms of cadmium intoxication may occur several years after the exposure. Until now in treating intoxication with this metal chelating compounds have been used, burdened with numerous undesirable symptoms. In our investigations anthocyanins from Aronia melanocarpa were used to reduce the harmful results caused by cadmium. Administering anthocyanins with cadmium chloride resulted in a statistically significant decrease of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, concentration of bilirubin and urea in blood serum and decreased cadmium cumulation in liver and kidneys in relation to animals receiving cadmium chloride only.
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