Micro-RNA in lung transplant recipients: the prospects of clinical application
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This review summarizes the current literature devoted to the analysis of diagnostic role of biomarkers in rejection of the transplanted lung. Numerous researches have focused on small non-coding RNAs (micro-RNA) that regulate gene expression and affect various cell functions. Variations in the concentration of different micro-RNA have been shown in some pathological processes, including rejection of solid organs. Probably, measuring the level of micro-RNA in lung transplant may have value in the assessment of risk of rejection and possibility of minimizing immunosuppressive therapy. The accumulation of clinical data on the correlation of profiles of various biomarkers with clinical and laboratory parameters in lung recipients will help in finding non-invasive methods for the diagnosis rejection and improving long-term results of transplantation.Cite
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AbstractThis paper reviews research conducted on the link between pathological gambling and substance misuse. We first examine the phenomenon of "pathological gambling," including similarities between pathological gambling and substance misuse, instruments used to measure pathological gambling, and the prevalence of pathological gambling in the United States and internationally. We then examine research on substance misuse among pathological gamblers, pathological gambling among substance misusers, and the treatment of the pathological gambler-substance misuser. We conclude with a discussion of future research needs.Key Words: Pathological gamblingSubstance misuseLiterature review
Substance misuse
Gambling disorder
Impulse control disorder
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Objective To explore the relationship between C-reactive protein and pathological changes of coronary artery.Methods One hundred and fifty-three patients who had no myocardial infarction,cardiac failure,injury,infection and cancer etc,and were approved by CAG were selected.The patients were retrospected in this study.Forty-three cases of the control group were normal coronary artery,39 cases with single vessel pathological changes,32 cases double vessel pathological changes,and 39 cases three vessel pathological changes,which were defined as single,double and three group respectively.The levels serum CRP of all patients were detected within 24 hours. Results There were significant differences among four groups. CRP levels of coronary heart disease were higher than that of control group.Serum CRP levels in three vessel pathological changes were higher than double vessel pathological changes and much higher than single vessel pathological changes. Conclusion Levels of serum CRP is correlated with pathological degree of coronary artery.
Coronary atherosclerosis
Coronary arteries
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Objective To study the relationship between the clinical and pathological characteristics in children patients with Henoch-SchSnlein purpura nephritics(HSPN).Methods We retrospectively reviewed the information of Clinical and pathological of 68 children with HSPN from January to July in 2009.Results A majority of patients exhibited hematuria,proteinunia,isolated hematuria and nephrotic syndrome while a minority showed the rapidly progressive glomerulonephritis.The pathological performs were mesangical proliferation,glomerulosclerosis and crescent formation.Most of pathological classifications were gradeⅡ or Ⅲ.Conclusions Grade Ⅱand Ⅲ of pathological classification have been seen in the majority of HPSN patients,and the clinical manifestations were closely associated with pathological classification.
Purpura (gastropod)
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Objective To estimate the effectiveness of fluoxatine treatment in patients with pathological crying and pathological laughing after brain stroke. Methods Seventeen pathological crying patients and 14 pathological crying with pathological laughing patients were included and was treated with fluoxatine (20 mg/d) for 4 weeks in this study. Results Fluoxatine is effective in the treatment of both pathological crying and laughing,but the efficacy in pathological crying is better than that in pathological laughing patients. Although HAMD scale(17 items) in most of these patients was higher than 17 scores,the improvement in emotional lability was independent on depression status. Conclusions 5-serotonine system might play an important role in pathological crying and laughing after stroke. It remains unclear whether the anatomic basis and pathogenesis of pathological crying and laughing is same.
Stroke
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We developed an ex vivo lung CT (EVL-CT) technique that allows us to obtain detailed CT images and morphologically assess the retrieved lung from a donor for transplantation. After we recovered the lung graft from a brain-dead donor, we transported it to our hospital and CT images were obtained ex vivo before lung transplant surgery. The objective of this study was to investigate the correlation between the EVL-CT findings and post-transplant outcome in patients who underwent bilateral lung transplantation (BLT) or single lung transplantation (SLT).We retrospectively reviewed the records of 70 patients with available EVL-CT data who underwent BLT (34 cases) or SLT (36 cases) in our hospital between October 2007 and September 2017. The recipients were divided into 2 groups (control group, infiltration group) according to the findings of EVL-CT of the lung graft in BLT and SLT, respectively. Recipients in the control group were transplanted lung grafts without any infiltrates (BLT control group, SLT control group). Recipients in the infiltration group received lung grafts with infiltrates (BLT infiltration group, SLT infiltration group).The recipients in the BLT infiltration group showed significantly slower recovery from primary graft dysfunction and a longer mechanical ventilation period and ICU stay period than those in the BLT control group. The mechanical ventilation period was significantly longer in the recipients in the SLT infiltration group than those in the SLT control group.EVL-CT may predict the outcome of the early phase after lung transplantation.
Ex vivo
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Study on pathological diagnosis of pathological changes of 457 patients with atypical squamous cells
Objective To discuss the pathological diagnosis of pathological changes.Methods The 457 patients with pathological changes of cervical atypical squamous cells were further investigated by colposcope and multiple cervical biopsies for pathological analysis.Results The rates of cervical epitheilial neoplasma II(CINⅡ) of ASC-US and ASC-H were 8.15%(34/417) and 35%(14/40),showing significant defferences between the two groups(P0.01).Conclusion Pathological analysis be carried out for early diagnosis of cervical epithelial neoplams.
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Obstructive lung disease
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Purpese: Lung transplantation is now accepted as an effective therapy for end-stage pulmonary vascular and parenchymal diseases. Rejection is a major impediment to long-term survival of lung transplant recipients. Lung allograft rejection has been studied in various animal models. To study the immunological mechanism of its rejection the studies on lung allograft rejection must be performed in inbred animals such as mice or rats, However, it is very delicate and difficult to transplant the lung in small inbred animals, especially in mice. The technical difficulty hampered the investigations of lung allograft rejection. Methods: This study introduced the new lung transplantation technique in mice for immunological study, subcutaneous lung tissue transplantation, in which the piece of lung tissue with 1-1.5 mm thickness was introduced subcutaneously through incision site on flank and transplanted to subcutaneous site of shoulder of mouse. Histological changes were followed up in transplanted lung tissues for 18 to 21 days. Lung tissues from CBA mice or Balb/c mice were subcutaneously transplanted to Balb/c mice in experimental or control group respectively. Results: Histological changes in the grafts of experimental groups could be divided into 4 phases, inflammatory, immunological, necrotic and fibrotic phase, Immunological or necrotic phase in this study correlated with grade 1-3 or grade 3-4 of acute lung rejection classified by the Lung Rejection Study Group. Conclusion: It is concluded that the subcutaneous lung tissue transplantation can be a technique for immunological study on acute lung allograft rejection in mice.
Parenchyma
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Make the use of B physical gallbladder for pathological changes of physical gallbladder.By the contrast of the operation and pathological changes analyse and have a discussion.We can see that the pathological changes of bulging pathological changes are different from pathological changes and the representation of sounds and pictures.Conclusion:the percent of ultrasonic exam for bulging pathological changes has reached over 90 percent and it has no wounds and have a repetition.At present the sensibility is the first among the method of diagnose of sounds and pictures.
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