Peculiarities of Metabolism of Rats with Fructose-induced Insulin Resistance Against the Background of Congenital and Acquired Iodine Deficiency
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Abstract:
Animals following a high-fructose diet during eight weeks, have experienced changes in metabolism and the signs of insulin resistance have developed. Under such conditions, moderate hyperglycemia, hyperinsulinemia, hyperuricemia, an increase of the level of glycosylated hemoglobin in whole blood were observed. The significant role of the HOMA-IR index, as an early marker of carbohydrate metabolism disorders at the stage of pre-diabetes, has been confirmed. In experimental animals against the background of the high-fructose diet, the changes in the lipid spectrum of the blood were revealed: an increase of the total cholesterol level, low-density lipoproteins, triglycerides against the background of a high-density lipoproteins decrease. These disorders and a significant increase of the atherogenicity reflect the development of secondary dyslipidemia. In this case, the disorders of carbohydrate metabolism were combined with the degree of dyslipidemia. Males were found to have at increased risk of development the insulin resistance and comorbid pathology. Iodine deficiency, especially of congenital nature, is an aggravating factor of metabolic disorders. The obtained data can serve as a basis for extend of preventive measures and identification of the priority treatment schemes for type 2 diabetes mellitus in residents of endemic regions.Keywords:
Dyslipidemia
Hyperinsulinemia
Carbohydrate Metabolism
Metabolism disorder
Metabolic disorder
Lipid Metabolism Disorder
Objective To investigate the relationship between hyperuricemia and lipid metabolism abnormality.Methods The uricemia(UA),total cholesterol(TC) in the blood fat,triglyceride(TG),high density lipoprotein(LDL-C)of 3176 people for health examination were analyzed.The rates of finding hyperuricemia for different genders were compared.The UA level and lipid metabolism abnormality of males(the normal UA group and the hyperUA group) and females(the normal UA group and the hyperUA group) were given statistical analysis.Results The rate of hyperuricemia was 18.98%(706cases),in which male accounted for 25.58% and female 17.54%.Male had higher rate of hypercuricemia(P0.01).In the 706 cases with hyperuricemia,502 cases(71.10%) were detected with lipid metabolism,in which male accounted for 53.97% and female 17.14%.Each index of lipid metabolism abnormality in the male hyper UA group was higher those of the male normal UA group.Except for HDL-C,each index in the female hyper UA group also was higher than those of the female normal group.Conclusion In the cases of hyperuricemia,there are more males than females.And the lipid metorbolism abnormality of people with hypercuricemia is more than that of normal people.To maintain the blood fat at a normal level is good for prevention of hyperuricemia.
Abnormality
Normal group
Lipid Metabolism Disorder
Metabolism disorder
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Metabolism disorder
Lipid Metabolism Disorder
Metabolic disorder
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Objective To analyze the prevalence of hyperuricemia and metabolism syndrome in the army retired officers in Sichuan and investigate the relativity of hyperuricemia with metabolism syndrome among these people.Methods The medical examination results of serum uric acid(SUA),cholesterol,triglycerides,blood sugar,blood pressure and body weight were analyzed statistically in 2582 army retired officers in Sichuan.Results Among 2785 participants,2582 male(92.7%)and 203 female(7.3%)were surveyed.The total morbidity rate of hyperuricemia and metabolic syndrome were 25.9% and 28.5%,respectively.Body mass index(BMI),blood pressure,triglyceride and fasting blood-glucose in the hyperuricemia group were significantly higher and the high density lipoprotein is lower than those in the normal group(P0.05).Conclusion The morbidity rate of hyperuricemia and metabolism syndrome in the retired officers of army in Sichuan is high.A clear relevance is shown between hyperuricemia and BMI,blood pressure,triglycerides and fasting blood-glucose.
Metabolism disorder
Blood sugar
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OBJECTIVE To make clear the morbidity and correlative factors of hyperuricemia among middle-and-old aged (45 years old and above)people. METHODS On the basis of cluster sampling,we select 5 137 cases as study samples from the 6 279 investigated ones to measure their serum uric acid,glucose,blood lipids,height,weight and blood pressure. RESULTS The morbidity of hyperuricemia is 19.95% among the people 45 years old and above in Xiaoshan District,in which male is 38.41%,female 10.03%. Hypertension,abnormal blood sugar,blood lipid disorders or obesity occur more frequently in the hyperuricemia group than in the normal.CONCLUSIONS A clear relevance has been certified between hyperuricemia and the metabolism syndrome including hypertension,diabetes,abnormal lipid metabolism and obesity.
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To investigate the disorder of lipid metabolism in type 2diabetic patients. To assessed the association of cholesterol and apolipoprotein with derangement of glucose metabolism.The levels of TC, TG, HDL-C, LDL-C, Apo A1, Apo A2, Apo AB48, Apo B100 and Apo E were all measured in 60 type 2 diabetic patients and 60 healthy controls. The differences of these clinical indicators in the two groups have been compared. Correlation analysis, multiple regression analysis have been applied in this paper.The levels of TC, TG, LDL-C were significantly higher( P < 0. 01) and the level of HDL-C was significantly lower( P < 0. 01) in patients with type 2 diabetes which indicating a lipid metabolic abnormalities. The levels of Apo A2, Apo B100, Apo E were significantly higher in type 2 diabetic patients than those in control group. Multiple regression analysis showed that Apo B100, Apo B48, LDL-C, TG were the main factors of FBG level. It was showed that apolipoproteins, especially Apo B, isassociated with glucose metabolism disorder.T2 DM patients are obviously associated with abnormal lipid metabolism, and the apolipoproteins may play an important role in derangement of glucose metabolism.
Metabolism disorder
Metabolic disorder
Lipid Metabolism Disorder
Carbohydrate Metabolism
Lipid Profile
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AbstractOne hundred consecutive patients with a clinical suspicion of metabolic inner ear disorder were submitted to a 5-hour glucose tolerance test with simultaneous titration of insulin. It was found that 82% of the patients presented abnormal glucose and/or insulin values. The analysis of the results revealed hypo- or hyperglycemia were present in only 41 % of the cases, and that all patients had normal fast values for glucose. Hyperinsulinemia was the most frequent abnormality and was found to constitute the determining factor of the inner ear disorders. 26 of the patients presented Meniere's disease. The pathophysiological model for insulin-induced Meniere's disease is discussed. Follow-up data indicate that these patients respond well to a diet with reduced intake of small molecule carbohydrates.
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To study the relationship between lipid metabolism disorder and TCM syndromes in type Ⅱ diabetes,the level of blood cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL),low density lipoprotein (LDL),apolipoprotein AI and B were tested in 75 patients,and 23 normal cases as control,after being divided into the syndrome of hyperactivity YANG due to YIN deficiency and the syndrome of deficiency of both YIN and YANG. The result showed that there were significant differences between the observation and control group.It indicates that there is serious lipid metabolism disorder which is related to the TCM syndromes differentiation in type Ⅱ diabetes.It implies that an active treatment of reducing lipid should be used.
Lipid Metabolism Disorder
Metabolism disorder
Metabolic disorder
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Lipid Profile
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OBJECTIVE To study the effects of compound of Chinese rhubarb and active carbon on lipid metabolism disorder in rats model of chronic renal insufficiency induced by 7/8 nephrectomy.METHODSIt was established that rats model of chronic renal insufficiency induced by 7/8 nephrectomy to observe the content of total cholesterol, triglyce ride, Apo A 1 and Apo B in serum between the treatment and control group in 16 weeks.RESULTS It was found that total cholesterol, triglyceride and the rate of Apo A 1/Apo B in the treatment group were significantly lower than that in the control group, and Apo A 1 and Apo B had no changes between two groups.CONCLUSIONS The compound of Chinese rhubarb and active carbon can improve the lipid metabolism disorder in rats model of chronic renal insufficiency induced by 7/8 nephrectomy.
Chronic renal insufficiency
Metabolic disorder
Metabolism disorder
Lipid Metabolism Disorder
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Authors examined 539 schoolgirls in the age 7-16 years old. Dosorders of lipid metabolism occurred in 48.4% of cases; hyperuricemia more than 0.32 mmol/l--in 25% of cases; excessive body weight and obesity--in 15% of cases. So more than half of female population some metabolic disorders. High frequency of metabolic disorders prove the necessity of dietetic correction in dependence on type of prevailed metabolic changes. Diet counted all the amount of metabolic disorders must be most effective.
Metabolism disorder
Metabolic disorder
Purine metabolism
Lipid Metabolism Disorder
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