PRELIMINARY DATA FROM SENECA (SEARCHING BIOMARKERS FOR CEREBRAL ANGIOPATHY): AN ITALIAN NETWORK FOR THE STUDY OF CEREBRAL AMYLOID ANGIOPATHY.
Emma ScelzoAnna BersanoLaura GattiSara NavaGiorgio GiacconePaola CaroppoFrancesco Di FedeLuisa ChiappariniAlessandra ErbettaPaolo VitaliAndrea MorottiEugenio ParatiStefania Bianchi MarzoliLaura ObiciMassimo Gasparini
0
Citation
0
Reference
20
Related Paper
Keywords:
Angiopathy
Amyloid (mycology)
Neuroradiology
Amyloid (mycology)
Cite
Citations (4)
Amyloid (mycology)
Angiopathy
Cite
Citations (0)
Deposition of amyloid-β (Aβ) in vessel walls of the brain as cerebral amyloid angiopathy (CAA) could be a major factor in the pathogenesis of dementia. Here we investigate the relationship between dementia and the prevalence of CAA in older populations. We searched the literature for prospective population-based epidemiological clinicopathological studies, free of the biases of other sampling techniques, which were used as a comparison. To identify population-based studies assessing CAA and dementia, a previous systematic review of population-based clinicopathological studies of ageing and dementia was employed. To identify selected-sample studies, PsychInfo (1806–April Week 3 2008), OVID MEDLINE (1950–April Week 2 2008) and Pubmed (searched 21 April 2008) databases were searched using the term "amyloid angiopathy". These databases were also employed to search for any population-based studies not included in the previous systematic review. Studies were included if they reported the prevalence of CAA relative to a dementia classification (clinical or neuropathological). Four population-based studies were identified. They showed that on average 55–59% of those with dementia displayed CAA (of any severity) compared to 28–38% of the non-demented. 37–43% of the demented displayed severe CAA in contrast to 7–24% of the non-demented. There was no overlap in the range of these averages and they were less variable and lower than those reported in 38 selected sample studies (demented v non-demented: 32–100 v 0–77% regardless of severity; 0–50 v 0–11% for severe only). CAA prevalence in populations is consistently higher in the demented as compared to the non-demented. This supports a significant role for CAA in the pathogenesis of dementia.
Cite
Citations (164)
in this area, as in many others, the effects of the relentless Cerebral amyloid angiopathy (CAA) is the accumulation of decline in autopsy rates and the heated debate on organ leptomeningeal and cortical vessel amyloid in the ageing retention, will be keenly felt.Sandwiched between are brain.It exists in familial and sporadic forms, is associated contributions on the chemistry and immunochemistry of with a variety of stroke subtypes, in particular recurrent lobar amyloid β-protein in CAA.It is here the contentious issue haemorrhages, and is a pathological feature in over 80% of as to the cellular origin of vascular amyloid is raised-Alzheimer disease brains.This multi-author text aims to vascular smooth muscle cells, cerebrospinal fluid, blood or weave together the threads of what is known about this even brain cells?There is also a chapter devoted to the common age-related vasculopathy at clinical, pathological, topical subject of a possible role for microvascular factors molecular and genetic levels.
Cite
Citations (3)
Amyloid (mycology)
Angiopathy
Cite
Citations (1)
Cerebral amyloid angiopathy (CAA) results from deposition of β-amyloid in the media and adventitia of small arteries and capillaries of the leptomeninges and cerebral cortex and is a major cause of lobar intracerebral hemorrhage and cognitive impairment in the elderly. CAA is associated with a high prevalence of magnetic resonance imaging markers of small vessel disease, including cerebral microbleeds and white matter hyperintensities. Although advanced CAA is present in approximately ¼ of brains with Alzheimer disease (AD), fewer than half of CAA cases meet pathologic criteria for AD. This review will discuss the pathophysiology of CAA and focus on new imaging modalities and laboratory biomarkers that may aid in the clinical diagnosis of individuals with the disease.
Leptomeninges
Amyloid (mycology)
Pathophysiology
Cite
Citations (546)
Angiopathy
Amyloid (mycology)
Cite
Citations (8)
ＯｂｊｅｃｔｉｖｅｓＴｏｓｔｕｄｙｃｌｉｎｉｃｏｐａｔｈｏｌｏｇｉｃａｌｙ１７ｃａｓｅｓｏｆｃｅｒｅｂｒａｌａｍｙｌｏｉｄａｎｇｉｏｐａｔｈｙ（ＣＡＡ）ｗｉｔｈｄｅｍｅｎｔｉａａｎｄｔｏｉｎｖｅｓｔｉｇａｔｅｔｈｅｐｏｓｓｉｂｌｅｎｅｕｒｏｐａｔｈｏ...
Angiopathy
Amyloid (mycology)
Cite
Citations (0)
Cerebrovascular Diseases provides up-to-date information on clinical features, epidemiology, imaging methods, genetics, pathophysiology, pathology and ...
Amyloid (mycology)
Angiopathy
Cite
Citations (9)