The Variation of Platelet Function in Gestational Diabetes Mellitus.
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Mean platelet volume
Objective: Mean platelet volume (MPV) and platelet distribution width (PDW) are parameters that indicate platelet volume. It is assumed that large platelets are enzymatically and metabolically more active than small platelets. The relationship between elevated MPV and PDW values and arterial thrombosis has been demonstrated, but their roles in venous thrombosis are not fully understood. While the platelet / lymphocyte ratio (PLR), which is considered to be an inflammatory indicator, is known to be associated with many diseases, there are only a few studies in venous thrombosis. For this reason, our aim in this study is to establish the relationship between MPV, PDW and PLR values and cerebral venous sinus thrombosis (CVST). Method: Our study included 54 patients who were diagnosed with CVST in our clinic between January 2008 and September 2016, and 50 controls with similar age and sex. The patients and control groups were compared in terms of MPV, PDW and PLR values. In addition, the patient group was divided into two groups, according to parenchymal brain lesions, and the effect of MPV, PDW, and PLR on prognosis was also assessed. Results: While the MPV, PDW and PLR values were higher in the patient group compared to the controls, there was no significant difference between patients with and without parenchymal lesions. In addition, as MPV and PDW values for CVST development were determined as significant independent variables, optimal cut-off values were identified 8.85 for MPV, 15.75 for PDW and 168.53 for PLR in ROC analysis. Conclusions: As a result, MPV, PDW and PLR values were higher in patients with SVST than controls, however their prognostic significance was not determined. In addition, we may suggest that higher MPV and PDW values are new independent risk factors for CVST development.
Mean platelet volume
Venous blood
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Background: Changes in platelet volume indices have been found in infectious diseases. Higher MPV [mean platelet volume] and PDW [platelet development width] values were observed in patients with sepsis compared to the patients who did not have sepsis. It is emphasized that indices might be helpful indices in predicting survival in sepsis. Material and Methods: A total of 54 newborns (sepsis group) and 55 healthy newborns (control group) were evaluated in this study. The groups were evaluated in terms of significant differences in the values of mean platelet volume and platelet distribution width. A p value of <0.05 was considered statistically significant for all results. Results: The study revealed statistically significant MPV and CRP in neonates with sepsis comapred to healthy neonatal subjects on day 1 and 3. Conclusion: It is concluded that increased level of MPV and CRP on day 1 and day 3 (p<0.001) and proposes that these observations can be useful in detecting inflammation in early neonatal life and mortality risk.
Mean platelet volume
Neonatal Sepsis
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Platelet indices are potentially useful markers for the early diagnosis of thromboembolic diseases. An increase in both mean platelet volume (MPV) and platelet distribution width (PDW) due to platelet activation, resulting from platelet swelling and pseudopodia formation was hypothesized.Platelet indices (MPV and PDW) in three groups of persons, using impedance and optical technology were measured. The first group consisted of patients with established platelet activation and healthy control subjects. The second study group included pregnant women in different trimesters of pregnancy. The effect of storage time on MPV and PDW in blood samples of a third group of randomly chosen patients was also assessed.There was a significant increase in MPV (P<0.001) and PDW (P<0.001) in patients with confirmed platelet activation compared to healthy control subjects. Only PDW showed a significant increase from the first to the third trimester of pregnancy (P=0.009). Temporal changes of MPV and PDW over storage time revealed a significant increase in MPV (P<0.001), in contrast to a significant decrease in PDW (P<0.05).MPV and PDW are simple platelet indices, which increase during platelet activation. PDW is a more specific marker of platelet activation, since it does not increase during simple platelet swelling.
Mean platelet volume
Coagulation system
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Abstract: Symptoms and findings in acute perforated appendicitis (APA) may not always typical in children, becomes difficult to establish the diagnosis preoperatively. Rapid and accurate diagnosis is important to reduce the risk of sepsis and even death. Another biomarkers for diagnosis are needed. This study investigated the diagnostic accuracy of indicators of platelet activation, namely mean platelet volume and platelet distribution width, in children with non perforated acute appendicitis (NPAA) and APA. This retrospective study compared 15 patients with APA (Group I), 15 patients with NPAA (Group II) between January 2016 to December 2018. Patient white blood cell (WBC) count, platelet (PLT) count, MPV, PDW, and hematocrit (HCT) were analyzed. Receiver operating characteristic (ROC) curves were used to evaluate the sensitivity and specificity of these indices in AP. Positive correlation was found between MPV and the degree of AP; as well as negative correlation between PDW and degree of AP. This is the first study to assess the MPV and PDW in pediatric patients with AP. This study showed the MPV is reduced and the PDW is normal in patients with AP. A decreased MPV value could serve as a marker to diagnose AP preoperatively. More studies are needed to establish relationship between PDW and MPV with AP. Keywords: Appendicitis perforations; Mean Platelet Volume; Platelet distribution width
Mean platelet volume
White blood cell
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Background Mean platelet volume ( MPV ) and plateletcrit ( PCT ) are indices used in evaluating immune‐mediated thrombocytopenia ( IMT ) in humans and in dogs with congenital macrothrombocytopenia. These indices may provide clinically valuable information in acquired thrombocytopenia. Hypothesis/Objectives Dogs with presumed primary IMT will have increased MPV , and therefore platelet mass ( PCT ) will increase faster than platelet count ( PLT ) during recovery. Animals Forty‐nine dogs with automated PLT < 30,000/μL because of presumed primary IMT and hematocrit ( HCT ), PCT , MPV , and platelet distribution width determined from the same complete blood count ( CBC ), and 46 healthy controls. Methods Case‐control retrospective study; PLT , PCT , MPV , and platelet distribution width ( PDW ) were recorded from CBC s from 49 dogs, with 45 having data collected on the day of presentation. Fifteen were confirmed to have attained a PLT ≥ 75,000/μL on at least 1 CBC within 15 days after admission. The PCT equivalent to a PLT of 75,000/μL (assuming an average MPV ) was calculated for comparison with PLT in terms of time to achieve a threshold of platelet mass by the 2 measures. Results Mean platelet volume was higher in IMT dogs (17.3 fl) than the reference population (10.5 fl) ( P < .0001). The PDW was not significantly different among the groups. The median time for PCT to reach threshold in confirmed responders was faster (3 days) compared with PLT (4 days). Conclusions and Clinical Importance Immune‐mediated thrombocytopenia is characterized by increased MPV . Time to achieve a threshold PCT tended to be shorter than PLT , suggesting that PCT may be a useful platelet parameter for monitoring dogs with IMT .
Mean platelet volume
Complete blood count
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Infective endocarditis (IE), an infection of the endocardial surface, frequently leads to life-threatening complications, such as thromboembolism due to platelet activation. We investigated the mean platelet volume (MPV) in Korean patients with IE and the serial changes thereof, in comparison with other laboratory parameters. We analyzed 248 MPV results from 22 patients diagnosed with IE in our hospital between January 2011 and April 2012. MPV was measured with an Advia 2120 (Siemens Healthcare Diagnostics, Tarrytown, NY) using EDTA-containing tubes. The mean MPV differed significantly between the patient and control groups, 8.74 vs. 7.96 fl, respectively. In addition, the platelet count and MPV/platelet count ratio were significantly decreased in the patient group. The total platelet mass and platelet size in IE might be increased. Further studies should examine more patients to verify the changes in the MPV and MPV/platelet count ratio in IE and assess in greater detail the relationship between MPV and thrombotic complications caused by platelet activation.
Mean platelet volume
Infective Endocarditis
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Mean platelet volume
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Objective: To evaluate the feasibility of platelet distribution width(PDW) for platelet activation.Methods: Mean platelet volume(MPV) and PDW in three groups of persons,using Sysmex XE-2100 hematology analyzer,were measured.The first group were healthy control subjects.The second study group were patients with established platelet activation.The third group were randomly chosen patients,whose MPV and PDW were assessed based on the effect of storage time.Results: There was a significant increase in MPV and PDW in patients with established platelet activation compared with healthy control subjects(P0.001).A significant increase was observed in MPV(P0.05),but decrease in PDW over storage time(P0.01).Conclusion: PDW is a more specific marker of platelet activation than MPV is,and the detection method with PDW is simple and accurate.PDW increases obviously during platelet activation,whereas it decreases during simple platelet swelling over storage time.
Mean platelet volume
Hematology analyzer
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Recently, some of the hemogram parameters were reported to predict early death in acute pulmonary embolism (PE). The aim of this study was to investigate the role of mean platelet volume (MPV) and MPV/platelet count ratio (MPV/P), WBC and red cell distribution width (RDW) in risk stratification of patients with acute PE. We retrospectively reviewed the medical records of patients with acute PE admitted to the Emergency Department. In addition to the clinical evaluation, the hemogram parameters were measured on admission. A total of 152 patients were included. Patients with RV dysfunction had significantly higher MPV levels and MPV/P than patients without RV dysfunction. Receiver operating characteristic curve analysis revealed that a MPV cut-off of 7.85 fL provided a sensitivity of 53.3% and a specificity of 68.5%, and a MPV/P cut-off of 0.0339 fL/(109/L) provided a sensitivity of 69.6% and a specificity of 65% for the prediction of RV dysfunction. There was a positive correlation between MPV and systolic pulmonary artery pressure (SPAP) and between MPV and RV diameter. There was a positive correlation between MPV/P and SPAP and between MPV/P and RV diameter. The low-risk PE group had lower MPV and MPV/P than the massive PE and submassive PE groups. MPV and MPV/P were found to be associated with RV dysfunction and clinical severity in acute PE. Low MPV and MPV/P levels may be an indicator of low risk and, high WBC levels may be an indicator of high risk in patients with acute PE. RDW levels may not reflect severity of acute PE.
Mean platelet volume
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Mean platelet volume
Carditis
Erythrocyte sedimentation rate
Acute rheumatic fever
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