Anthraquinones from Cassia fistula and Their Anti-tobacco Mosaic Virus Activity
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Two new isoaurones, siamaurones A and B (1-2), together with three known isoaurones (3-5) were isolated from the stems of Cassia siamea.The structures of 1-5 were elucidated by spectroscopic methods including 1D-and 2D-NMR techniques.Compounds 1-5 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activity.As a result, compound 2 showed high anti-TMV activity with inhibition rate of 31.8%, which is higher than that of Ningnanmycin (26.5%).Compounds 1, 3, and 5 showed modest anti-TMV activity with inhibition rate of 15.2%, 16.4%, and 12.8%, respectively.Cassia siamea Lam.(Leguminosae) is a common tree in the southern part of China.It has been used widely in traditional medicine, particularly for treatment of periodic fever, alaria, aperient, antiarthritic and swellings. 1,2In previous work, a number of bioactive compounds, such as anthraquinone, 3,4 alkaloids, 5,6 triperpenoids, 7,8 steroids, 8,9 chromones, [10][11][12] and their homologous, were isolated from this plant.Motivated by a search for new bioactive metabolites from this plant, our group has investigated the chemical constituents of the stems of C. siamea, which led to the isolation and characterization of two
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Sophora
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Three previously unreported anthraquinones, fistulaquinones A–C (1–3), together with three known ones (4–6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of extensive NMR and MS spectroscopic analyses. All the isolated compounds were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 showed significant activity with inhibition rate of 34.5% at 20 μM concentration, even more potent than positive control. Additionally, compounds 1–6 exhibited moderate cytotoxicity with IC50 values ranging from 2.8 to 9.4 μM for some tested human tumor cell lines.
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A new phenolic amide, (E)-3-(3,4-dihydroxyphenyl)-N-[2-(4-methoxyphenyl)-2-oxoethyl]-prop-2-enamide (1) was isolated from the stems of Cassia fistula. Its structure was elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 1 was also evaluated for its anti-tobacco mosaic virus (anti-TMV) activity and it exhibit potential anti-TMV activity with inhibition rates of 16.2 %.
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Tobacco etch virus
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Abstract : -Pods of cassia sophera. (Family Leguminoae) is a large tropical genus about One of 600 species of herbs, shrubs and trees. Most of the plants of the genus are well known in Indian system of medicine for their cathartic, purgative and antibiotic properties. Many compounds of structural significance and medicinal importance have been reported from different species of this genus. Species of Cassia are rich source of anthraquinones which are well known as natural dyes, and are gaining importance in recent years due to environmental pollution caused by synthetic dyes. This paper attempts to give an overview of literature on the isolated and characterized anthraquinones from various Cassia species and their repoted applications. Besides dye yielding properties they are used in cosmetics and pharmaceuticals. Thus plants of Cassia species can serve as commercial source of naturaly occurring anthraquinones
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Isoquinoline
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Abstract Three new chromones are isolated and shown to exhibit anti‐tobacco mosaic virus activities.
Mosaic virus
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