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    An Efficient Enantioselective Total Synthesis of a Trifluoromethyl Analogue of Blastmycinolactol.
    ChemInform (2004)
    P. Veeraraghavan RamachandranKamlesh J. PadiyaM. Venkat Ram ReddyHerbert C. Brown
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    Abstract:
    Abstract For Abstract see ChemInform Abstract in Full Text.
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    Enantioselective Total Synthesis of (+)‐Vittatalactone
    European Journal of Organic Chemistry (2011)
    J. S. YadavNagendra Nath YadavT. Srinivasa RaoB. V. Subba ReddyAhmad Al Khazim Al Ghamdi
    Abstract An enantioselective asymmetric total synthesis of (+)‐vittatalactone has been accomplished employing enzymatic desymmetrization approach to create two methyl chiral centres. Other key steps involved are Wittig reaction, Evan's asymmetric alkylation, hydroboration, TEMPO‐BAIB‐mediated selective oxidation of 1,3‐diol and lactonization mediated by p ‐toluenesulfonyl chloride. The total synthesis was achieved by a linear synthetic sequence with an overall yield of 11.8 %.
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    Wittig reaction
    Hydroboration
    Aldol reaction
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    Enantioselective Total Synthesis of (−)-Limaspermidine and Formal Synthesis of (−)-1-Acetylaspidoalbidine
    The Journal of Organic Chemistry (2013)
    Shaoxiong ZhangXiaolei ShenZe‐Qian LiLi‐Wei ZouFengqun Wang
    Evolution of the synthetic strategy that culminated in the first asymmetric total synthesis of the Aspidosperma alkaloid limaspermidine is described. The successful enantioselective route to (−)-limaspermidine proceeds in 10 steps and with the isolation of only six intermediates using a Pd-catalyzed enantioselective decarboxylative allylation we have recently developed. This first enantioselective synthesis of (−)-limaspermidine establishes unambiguously its absolute configuration and allows the first asymmetric formal total synthesis of the Aspidoalbine alkaloid (−)-1-acetylaspidoalbidine.
    Formal synthesis
    Citations (41)
    Chiral B(III) Lewis Acids
    Kazuaki Ishihara
    Mannich reaction
    Aldol reaction
    Hydrocyanation
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    Enantioselective Total Syntheses of the Cyclotryptamine Alkaloids Hodgkinsine and Hodgkinsine B
    Angewandte Chemie International Edition (2003)
    Jeremy J. KodankoLarry E. Overman
    A late-stage resolution of the meso-3a,3a′-bispyrrolidinoindoline unit of rac-7 in a catalytic asymmetric transformation earmarks the remarkably short, ten-step, total syntheses of hodgkinsine and hodgkinsine B. The enantioselective total synthesis of hodgkinsine B establishes the relative and absolute configuration of this trispyrrolidinoindoline alkaloid.
    Absolute Configuration
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    Enantioselective formal total synthesis of (−)-trachyspic acid
    Tetrahedron Letters (2009)
    Frederick CaloJeffery RichardsonAndrew J. P. WhiteAnthony G. M. Barrett
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    Methods of Asymmetric Synthesis—Enantioselective Catalytic Hydrogenation
    Angewandte Chemie International Edition (1971)
    Yoshiharu Izumi
    Abstract It is proposed that asymmetric syntheses be divided into enantioselective and diastereoselective syntheses. The enantioselective hydrogenations discussed in the present progress report were catalyzed by Raney nickel that had previously been treated with solutions of optically active compounds. Relationships exist between the enantioselectivity of the catalyst and the structure of the chiral compound used to modify it.
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    Asymmetric hydrogenation
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    Alternative Synthetic Strategies for Enantioselective Construction of Halogenated Chiral Carbon Centers
    Synthesis (2010)
    Kazutaka Shibatomi
    This review focuses on the enantioselective synthesis of halogenated molecules having a chiral halocarbon center. In particular, this review discusses enantioselective transformations with haloalkenes and enantioselective α-substitutions of α-halo carbonyl compounds. Enantioselective halogen-transfer reactions are excluded from this review.
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    ChemInform Abstract: Catalytic Enantioselective and Divergent Total Synthesis of (+)‐10‐Oxocylindrocarpidine, (+)‐Cylindrocarpidine, (‐)‐N‐Acetylcylindrocarpinol, and (+)‐Aspidospermine.
    ChemInform (2014)
    Xiaolei ShenRuirui ZhaoMingjie MoFangzhi PengHongbin Zhang
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    A short and efficient enantioselective route to a key intermediate for the total synthesis of forskolin
    Tetrahedron Letters (1989)
    E. J. CoreyPaul Da Silva Jardine
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