ChemInform Abstract: DOPAMINE RECEPTOR MODEL AND ITS APPLICATION IN THE DESIGN OF A NEW CLASS OF RIGID PYRROLO(2,3‐G)ISOQUINOLINE ANTIPSYCHOTICS
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In this paper,5-bromo-isoquinoline was synthesized with one step by use isoquinoline as start material.Then a series of isoquinoline derivatives such as 5-bromo-8-nitro-isoquinoline,8-amino-isoquinoline and 8-bromo-isoquinoline were synthesized from 5-bromo-isoquinoline.All products have been confirmed by IR,NMR and so on.
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Isoquinoline alkaloids are attractive natural products due to their diverse chemical structures as well as remarkable bioactivities. Herein, we report the concise total syntheses of two isoquinoline alkaloids, menisporphine and daurioxoisoporphine C, through a mild and efficient photoredox-catalyzed direct C–H arylation of isoquinoline core with aryldiazonium salt. This new strategy is complementary to the conventional isoquinoline synthesis and would provide us a useful means to achieve a more convergent and flexible approach to access diverse isoquinoline structures.
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