Correlation Between 18F-FDG PET/CT SUVmax and Clinicopathological Features, Neoadjuvant Chemotherapy Response in Invasive Ductal Breast Carcinoma Patients
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目的探讨18F-脱氧葡萄糖（FDG）正电子发射计算机断层扫描（PET/CT）显像治疗前病灶最大标准摄取值（maximum standard uptake value, SUVmax）与乳腺浸润性导管癌临床病理特征的关系及与新辅助化疗疗效的相关性，以指导临床个体化治疗。 方法选取佛山市第一人民医院行18F-FDG PET/CT显像的272例初治乳腺浸润性导管癌患者的临床资料进行回顾性分析，测定原发病灶的SUVmax，分析临床病理特征、分子分型及新辅助化疗疗效与原发灶SUVmax的相关性。 结果乳腺癌原发灶的SUVmax在不同T分期、不同组织学分级、有无淋巴结转移方面差异均有统计学意义（P 0.05），Ki-67高表达者SUVmax高于低表达者（P 结论18F-FDG PET/CT SUVmax与乳腺癌的临床病理特征具有较大的相关性，原发病灶SUVmax较高者更能从新辅助化疗中获益。Keywords:
Standardized uptake value
Breast carcinoma
PET-CT
To evaluate the potential clinical role and effectiveness of respiratory 4D-gating F-18 FDG PET/CT scan for liver malignancies, relative to routine (3D) F-18 FDG PET/CT scan.This study presented a prospective clinical study of 16 patients who received F-18 FDG PET/CT scan for known or suspected malignant liver lesions. Ethics approvals were obtained from the ethics committees of the Hong Kong Baptist Hospital and The Hong Kong Polytechnic University. Liver lesions were compared between the gated and ungated image sets, in terms of 1) volume measurement of PET image, 2) accuracy of maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and 3) accuracy of total lesion glycoses (TLG). Statistical analysis was performed by using a two-tailed paired Student t-test and Pearson correlation test.The study population consisted of 16 patients (9 males and 7 females; mean age of 65) with a total number of 89 lesions. The SUVmax and SUVmean measurement of the gated PET images was more accurate than that of the ungated PET images, compared to the static reference images. An average of 21.48% (p < 0.001) reduction of the tumor volume was also observed. The SUVmax and SUVmean of the gated PET images were improved by 19.81% (p < 0.001) and 25.53% (p < 0.001), compared to the ungated PET images.We have demonstrated the feasibility of implementing 4D PET/CT scan for liver malignancies in a prospective clinical study. The 4D PET/CT scan for liver malignancies could improve the quality of PET image by improving the SUV accuracy of the lesions and reducing image blurring. The improved accuracy in the classification and identification of liver tumors with 4D PET image would potentially lead to its increased utilization in target delineation of GTV, ITV, and PTV for liver radiotherapy treatment planning in the future.
Standardized uptake value
PET-CT
Liver Cancer
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Positron emission tomography (PET) is an imaging method that utilizes compounds labeled with positron-emitting radioisotopes as molecular probes to evaluate different neurophysiological processes quantitatively and noninvasively. This chapter provides a background regarding positron emission, radiotracer chemistry, and detector and scanner instrumentation, as well as analytical methods for evaluating basic brain physiology, such as cerebral blood flow and oxygen and glucose metabolism. The methodological aspects of PET imaging, such as patient preparation and optimal scanning parameters, are discussed. Examples of application of blood flow and metabolic imaging in both research and clinical scenarios for the evaluation of normal neurophysiology are provided. Recent advances in PET imaging, including PET-CT and PET-MRI, are also described. Finally, the unique strengths of PET imaging are highlighted.
PET Imaging
Molecular Imaging
Positron emission
Functional Imaging
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The role of Positron Emission Tomography/Computed Tomography (PET/CT)
modalities is becoming more important concomitantly with the increase of
oncology cases in Malaysia. Thus, it is the perfect time to perform a study to
standardise the PET/CT image quality in Malaysia. This study aimed to compare
the quantification of image quality of PET/CT with a standardised uptake value
(SUV) parameter. In general, this study was carried out with the purpose of
identifying the standardisation of quantification of standardised uptake value,
SUVcontrolled for 18F-FDG PET between two independent PET modalities at two
different institutions.
The analysis was done on the SUVcontrolled of technical techniques (PET phantom)
as a control standard for the validation of the PET-CT images of selected subjects
with Fasting Blood Glucose index as the adjusted index to synchronise the two
independent data sets. It was found that the SUVcontrolled was a potential
conversion marker to validate the in vivo standardisation techniques for the two
independent PET/CT modality systems based on the reference standard of the
matched FBS and the in vitro 18F-FDG phantom. This study confirmed that the
two independent PET modalities at paired-centre could potentially be
standardised on the independent image quality based on the SUVmax
quantification as the two independent measured were insignificantly different.
Standardized uptake value
PET-CT
Modalities
Modality (human–computer interaction)
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Abstract Background The risk of cardiovascular disease (CVD) is elevated in metabolic syndrome (MS) and is related to the inflammatory activity of visceral adipose tissue (VAT). We investigated whether the metabolic activity in VAT, assessed by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), is associated with systemic inflammatory status, and related to the number of MS components. Methods 18F-FDG PET/CT was performed in a total of 203 subjects: 59 without an MS component; M(0), 92 with one or two MS components; M(1–2), and 52 with MS. Metabolic activity of VAT was evaluated using the mean standardized uptake value (SUVmean) and the maximum SUV (SUVmax). Metabolic activities of immune-related organs such as spleen and bone marrow (BM) were evaluated using the SUVmax. Results VAT SUVmax correlated with high-sensitivity C-reactive protein (hsCRP) and the SUVmax of spleen and BM, which reflect the status of systemic inflammation. Both hsCRP and the SUVmax of the spleen and BM were higher in the MS group than in the M(1–2) or M(0) groups. In VAT, SUVmax increased with increasing number of MS components, while SUVmean decreased. Conclusions The SUVmax of VAT assessed by 18F-FDG PET/CT could reflect the inflammatory activity of VAT which is increased in the MS patients with systemic inflammation. Funding Acknowledgement Type of funding source: None
Standardized uptake value
PET-CT
Fluorodeoxyglucose
Metabolic activity
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Positron emission tomography (PET) is a powerful quantitative molecular imaging technique that is complementary to structural imaging techniques for purposes of disease detection and characterization. This review article provides a brief overview of PET, hybrid PET instrumentation, and PET quantification.
Positron emission
Instrumentation
Molecular Imaging
PET Imaging
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Positron emission
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Small animal positron emission tomography/computed tomography (PET/CT) is an important preclinical tool to analyze disease mechanisms. Alterations in glucose utilization are associated with neurodegeneration and can be measured in [18F]FDG-PET/CT studies. Current analyzing strategies for small animal [18F]FDG-PET/CT Data do not facilitate full quantification as kinetic information of the blood radioactivity is usually missing. A continuous measurement of the blood tracer concentration might enable quantification but is technically challenging.
PET-CT
Blood sampling
PET Imaging
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PET-CT
Positron emission
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Standardized uptake value
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To review the current role and the limitations of F-fluorodeoxygenase positron emission tomography in the management of lymphoma, with a particular focus on studies published since January 2004.F-fluorodeoxygenase positron emission tomography should be routinely performed at the initial diagnosis of patients with suffering from Hodgkin's disease because it adds useful informations to conventional staging techniques. Residual F-fluorodeoxygenase uptake is an important prognostic factor after one or a few cycles of chemotherapy, but it is clearly too early to change patient treatment on the basis of F-fluorodeoxygenase positron emission tomography results. F-fluorodeoxygenase positron emission tomography is the best noninvasive imaging technique after treatment; however, it is always indicated to correlate positron emission tomography findings with clinical data, other imaging modalities, a biopsy, or all three to reduce the risk of false positive results. There are some concerns about the positive predictive value of positron emission tomography after treatment, especially in childhood lymphoma. Clinicians should be aware of positron emission tomography findings in specific clinical conditions in this patient population. F-fluorodeoxygenase positron emission tomography combined with computed tomography offers advantages over the two used separately and read side by side. It may be particularly useful for the planning of radiation therapy or for the planning of a surgical biopsy. Several studies have shown that F-fluorodeoxygenase positron emission tomography is definitively superior to Ga scintigraphy. New radiotracers such as F-fluorothymidine may be useful for the noninvasive assessment of proliferation in vivo.F-fluorodeoxygenase positron emission tomography has become the most important nuclear medicine imaging modality in the field of lymphoma. It should be routinely used in the treatment of lymphoma patients.
Positron emission
Emission computed tomography
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