Revealing the Synergistic Mechanism of Multiple Components in Compound Fengshiding Capsule for Rheumatoid Arthritis Therapeutics by Network Pharmacology
Hong DuanKefeng ZhaiGhulam Jilany KhanJie ZhouTing-yan CaoYuqi WuYaru ZhouGuangwen CaoGuizhen GaoLingling Shan
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Abstract:
Compound Fengshiding capsule (CFC), is a Chinese formulation from herbal origin including Alangium platanifolium, Angelicae dahurica, Cynanchum paniculatum and Glycyrrhiza uralensis. CFC is widely used as clinical therapy against rheumatoid arthritis. However, its exact mechanism of action has not been explored yet.In order to explore the synergistic mechanism of CFC, we designed a study adopting network pharmacology scheme to screen the action targets in relation to the CFC components. The study analyses target facts of salicin, paeonol, liquiritin and imperatorin from PubMed database, and explores the potential pharmacological targets of rheumatoid arthritis, cervical neuralgia and sciatica related diseases for their interaction.The results of boosted metabolic pathway showed that the chemical components of CFC interrupted many immune-related pathways, thus participating in immunity regulation of the body and playing a role in the treatment of rheumatism. Collectively, CFC has apoptotic, oxidative stress modulatory and anti-inflammatory effects that accumulatively serve for its clinical application against rheumatoid arthritis.Conclusively, our findings from present study reconnoiters and compacts systematic theoretical approach by utilizing the network pharmacology mechanism of four effective components for the treatment of rheumatism indicating sufficient potential drug targets associated with CFC against rheumatism. These interesting findings entreaties for further in vitro and in vivo studies on the mechanism of compound active ingredient against rheumatism.Keywords:
Glycyrrhiza uralensis
Mechanism of Action
The results of treatment of 73 transcervical and 49 extracapsular fractures of the femoral neck in patients with rheumatoid arthritis were compared with the results in 152 normal patients. In undisplaced transcervical fractures that were internally fixed and followed up for more than six months, there was no significant difference in results between the rheumatoid patients (5 acceptable results in 8 patients) and the control patients (8 acceptable results in 9 patients). In displaced fractures, when internally fixed, the rheumatoid group (8 acceptable results in 27 patients) did significantly less well than the control group (17 acceptable results in 30 patients). In hips affected by the disease, the results were worse (1 acceptable result in 9 patients). Hemiarthroplasty gave acceptable results in two-thirds of the rheumatoid patients with transcervical fractures, whether used as primary treatment of displaced fractures or as revision of failed pinnings. This was not affected significantly by the presence of disease in the joint. In extracapsular fractures, the presence of rheumatoid arthritis, whether or not it affected the hip, did not appear to affect the outcome. The presence of osteoporosis was associated with poor results.
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the investigator, could constitute a risk when taking investigational product or could interfere with the interpretation of data
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It is important that to give to consideration the optimal timing and order when performing multiple joint arthroplasties of lower extremities in patients with rheumatoid arthritis. We report our experience with 30 patients treated over a 15 year period.Their age at the time of first operation ranged from 32-72 years (average 55.3 years). The duration of their rheumatoid disease ranged from 9-49 years (average 22 years). We have followed the patients for 1-12 years (average 5.3 years).In patients with multiple joint destructive in the lower extremities, the first therapy to be performed should be correction of painful toe deformities. Secondary the most painful joint was operated on.Patients requiring multiple joint arthroplasties during one admission, or patients with cervical or lumbar spondilotic disturbance, and with joint destruction of upper extremities valued their total functional requirements and, decided their goal of therapy and in which order this should be achieved. When this was done, therapy. Produced good results.
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The therapeutic results of anti-rheumatic agents in the treatment of rheumatoid arthritis were as follows:These agents had good effects in acute signs and symptomes, but when the agents were discontinued, signs and symptomes reappeared, the ill-effects in the cases of cortisone and ACTH were absent, and in T. T. G and Salcylamid were slight. In Irgapyrin, edema was observed, but agranulocytosis was absent.
Signs and symptoms
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Total Knee Replacement
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