The effects of umblical cord clamping time on lymphocyte subgroups in term and late preterm infants
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To evaluate the effect of umblical cord clamping time on lymphocyte subgroups in term and late preterm infants.Seventy-four infants between 34 and 41 weeks of gestation were included in the study. Of these, 37 were umbilical cord clamped immediately after birth and the remaining 37 were clamped after waiting one minute. Babies were divided into two groups as term and preterm. The prenatal, natal, postnatal characteristics of the infants were recorded. Hematologic and lymphocyte subgroups were investigated in cord blood and venous blood at day 7. Lymphocyte subgroups were evaluated using flow cytometry.With the delay of cord clamping, the leucocytes count and the percentage of CD3+T lymphocytes in cord blood of preterm infants decreased and this decrease continued at day 7. On the contrary, CD19+B lymphocyte levels in the cord blood of preterm infants increased, and this increase continued at day 7. Also, the percentage of CD4+T lymphocytes of preterm infants decreased with the delay of cord clamping at day 7. There was no difference between groups for the rate of sepsis development.With the delay of cord clamping, the leucocytes count, the percentage of CD3+T, and CD4+T lymphocytes decreased, and the percentage of CD19+B lymphocytes increased in preterm infants. The delay in cord clamping time in term and preterm infants seems to have no impact on the rate of sepsis development. Larger series of studies are needed to assess the effect of these findings on the development of infection in late preterm infants who have delayed cord clamping.Keywords:
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Cord clamping
Neonatal Sepsis
Sir .—Recently, we saw a newborn who presented with swelling of the umbilical cord. The cord measured 70 mm at its attachment to the umbilicus (Figure). Examination on palpation revealed the presence of crepitus in the cord, and, interestingly, the abdominal roentgenogram revealed loops of bowel herniating through the defect in the umbilicus. The patient was immediately referred to a pediatric surgeon. Subsequently, we became concerned that if the cord had had been clamped near the base, it would have resulted in an intestinal obstruction. 1 This episode caused us to examine the following questions: (1) What is the normal size of the neonatal umbilical cord? (2) Do the newborn's measurements and weight have any relation ship to the size of the cord at birth? Review of the literature indicated that much is known about abnormalities of the cord, such as granulomas, infections, and hernias. However, we found no information about the normal cord circumference and the factors that correlate with it.
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Umbilical cord blood is an important graft source in the treatment of many genetic, hematologic, and immunologic disorders by hematopoietic stem cell transplantation. Millions of cord blood units have been collected and stored for clinical use since the inception of cord blood banking in 1989. However, the use of cord blood in biomedical research has been limited by access to viable samples. Here, we present a cost-effective, self-sustaining model for the procurement of fresh umbilical cord blood components for research purposes within hospital-affiliated academic institutions.
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The study was aimed to establish a standard procedure for human umbilical cord blood bank. The hematopoietic nucleated cells in cord blood were processed by using sedimentation and centrifugation method. After finishing CD34(+) cell counting, hematopoietic progenitor cell assay, microbial culture, infectious disease test and HLA typing, cord blood units were stored in the liquid nitrogen for further application. The results showed that nucleated cells of cord blood were (10.94 +/- 2.74) x 10(8) per unit; recovery rate of nucleated cells was (79.82 +/- 17.76)%. CD34(+) cells in cord blood were counted as (51.62 +/- 30.53) x 10(5) per unit. Eight units of cord blood were thawed after two years of cryopreservation, the recovery rate of nucleated cells, CD34(+) cells and CFU-GM were (91.4 +/- 6.0)%, (84.6 +/- 20.0)% and (85.8 +/- 14.9)% respectively. It is suggested that the methods and procedure reported for processing and cryopreservation of hematopoietic stem/progenitor cells in the human umbilical cord blood is effective.
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Background: As the new born is delivered and the umbilical cord divided, blood can be collected from the segment of cord, still attached to the placenta are known as “umbilical cord blood” stem cell. The blood collected in the umbilical cord is said to be a rich origin of stem. The blood contains stem cells which are also known as hematopoietic cells and these cells can convert into any types of organs in the body. These stem cells collected from the umbilical cord can heal genetic diseases related to blood and immune system like cancer, blood disorders and several life –threatening diseases. Objectives: Assess the level of knowledge regarding stem cells and cord blood banking among antenatal mothers. Find out the association between the level of knowledge regarding stem cells and cord blood banking among antenatal mothers with their selected demographic variables.
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Abstract This review presents the effects of delayed umbilical cord clamping on neonatal transitional physiology. The effects of delayed cord clamping on short- and long-term neonatal outcomes are then discussed. There is ample evidence over the last 50 years that delayed cord clamping in preterm infants is beneficial for both short-term and long-term outcomes. Providing ventilation in the initial steps of neonatal resuscitation prior to clamping of the umbilical cord has a physiologic basis and results in better outcomes for newborns. The challenge now is to design equipment and strategies that can allow initial resuscitation very close to the mother while the umbilical cord is still attached to the placenta.
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The length of umbilical cords was studied in 536 term deliveries to test the hypothesis that a short or long umbilical cord is more frequently associated with certain intrapartum complications. The mean umbilical cord length was 55 cm (range, 14 to 129 cm). A short cord was defined as 35 cm or less (lower sixth percentile). Umbilical cord accidents were most frequent in the presence of a long cord (20 of 32 cases, 62%). Inadequate fetal descent was significantly more common when a long cord or an excessively short cord (25 cm or less, lower first percentile) was found. Fetal heart rate (FHR) abnormalities that primarily reflected cord compression patterns were significantly more frequent in the presence of a short (17 of 27 cases, 63%) or a long cord (28 of 32 cases, 87%), as compared with a normal length cord (145 of 393 cases, 37%). The measurement of umbilical cord length requires minimal effort, no expense, and may explain certain intrapartum FHR abnormalities or an arrest of fetal descent.
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