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    The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration‐induced lesions
    Glia (2014)
    Kenneth L. PitterIlaria TamagnoXi FengKaushik GhosalNduka Amankulor
    In response to neurodegeneration, the adult mammalian brain activates a cellular cascade that results in reactive astrogliosis and microgliosis. The mechanism through which astrocytes become reactive and the physiological consequences of their activation in response to neurodegeneration is complex. While the activation and proliferation of astrocytes has been shown to occur during massive neuronal cell death, the functional relationship between these two events has not been clearly elucidated. Here we show that in response to kainic acid‐ (KA) induced neurodegeneration, the mitogen sonic hedgehog (SHH) is upregulated in reactive astrocytes. SHH activity peaks at 7 days and is accompanied by increased Gli activity and elevated proliferation in several cell types. To determine the functional role of SHH‐Gli signaling following KA lesions, we used a pharmacological approach to show that SHH secreted by astrocytes drives the activation and proliferation of astrocytes and microglia. The consequences of SHH‐Gli signaling in KA‐induced lesions appear to be independent of the severity of neurodegeneration. GLIA 2014;62:1595–1607
    Astrogliosis
    Neuroglia
    Citations (59)
    Decision letter for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"
    Encephalomyelitis
    Animal model
    Citations (0)
    Review for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"
    Luca Pellegrini
    Encephalomyelitis
    Citations (0)
    Review for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"
    CHIN-YI CHEN
    Encephalomyelitis
    Animal model
    Citations (0)
    Review for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"
    Luca Pellegrini
    Encephalomyelitis
    Animal model
    Citations (0)
    Review for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"
    CHIN-YI CHEN
    Encephalomyelitis
    Citations (0)
    Delayed neurodegeneration and early astrogliosis after excitotoxicity to the aged brain
    Experimental Gerontology (2006)
    Maria del Mar Castillo-RuizÓscar CampuzanoLaia AcarínBernardo CastellanoBerta González
    Astrogliosis
    Excitotoxicity
    Gliosis
    NeuN
    Citations (33)
    Decision letter for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"
    Encephalomyelitis
    Citations (0)
    The Beneficial Effects of Statins in the Treatment of Multiple Sclerosis
    Journal of Shanxi Datong University (2009)
    YU Jie-zhong
    A large number of animal experiments confirmed that statins can inhibit experimental autoimmune encephalomyelitis(EAE),clinical evidence suggests that statins can play therapeutic effects in multiple sclerosis(MS).Statin treatment of MS has a wider application prospect.
    Encephalomyelitis
    Therapeutic effect
    Citations (0)
    Decision letter for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"
    Encephalomyelitis
    Citations (0)