OLR1 gene polymorphism and oxidized LDL levels in metabolic syndrome in Indian population
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Objective: Metabolic syndrome (MetS) is associated with abnormal lipid profile and high cardiovascular risk. There is an increased prevalence of coronary artery disease and Type 2 Diabetes Mellitus in India. Oxidized Low Density Lipoprotein Receptor 1(OLR1), a cell surface endocytosis receptor recognize, internalize and degrade oxidized LDL (oxLDL) in vascular endothelium and plays a role in the pathogenesis of atherosclerosis. The aim was to explore the association of OLR1 gene polymorphism and measure the serum levels of ox-LDL in patients with MetS in Indian population. Materials and Methods: Forty cases fulfilling the IDF diagnostic criteria for MetS and 40 healthy controls having similar age and sex ratio were genotyped for OLR1 gene (SNP: IVS4–73C>T , rs3736234) by RFLP-PCR. Serum ox-LDL was estimated by ELISA.Their BP, BMI and waist circumference were measured. Fasting Plasma glucose, Serum Triglyceride and HDL-C were measured. Results: Serum oxLDL was significantly higher in MetS cases as compared to controls (p < 0.0001). Odds ratio of T allele of above OLR1 SNP among subjects with MetS was 14.79 (95%CI: 1.80-121.2, p < 0.05). But no association was found between the SNP and serum ox-LDL levels. People having TT allele had higher BMI compared to those having CC allele. Conclusion: Ox LDL, being more atherogenic might contribute in the pathogenesis of MetS. The intronic SNP: IVS4-73 C>T of OLR1 gene increases the risk of developing MetS by a yet unknown mechanism that is independent of rise in ox-LDL. This OLR1 SNP probably influences BMI.To explore the effects of combined CYP1A1 Msp1 genotypes with Ile/Val genotypes on susceptibility to lung cancer. Msp1 and Ile/Val genotypes of CYP1A1 gene were detected with the methods of PCR RFLP and allele specific amplification(ASA) in a case control study,including 92 cases of lung cancer and 98 hospital controls. Msp1 polymorphism site:The risk of lung cancer with the individuals of genotype B or genotype C was 1 85 times greater than that with the individual of genotype A ( χ 2=4 36,P0 05,OR=1 85,95% CI 1 04～3 30 ).Ile/Val polymorphism site:The risk of lung cancer of the individuals with genotype Val/Val was 3 3 times greater than the individual with genotype Ile/Ile ( χ 2=4 12,P0 05,OR=3 3,95% CI 1 02～10 72 ).The lung cancer risks of individuals with combined Ile/Ile genotype and A genotype were compared with these of individuals combined Ile/Val genotype and B ( χ 2=5 81,P0 05,95% CI 1 7～9 96 ),the individuals combined Ile/Val genotype and C genotype ( χ 2=4 74,P0 05,95% CI 1 11～20 9 ) and the individuals combined Val/Val genotype and C genotype ( χ 2=4 42,P0 05,95% CI 1 27～23 6 ). [Conclusion] The genotype C and genotype Val/Val of CYP1A1 gene may be susceptible to lung cancer,the individuals with two susceptible genotypes were more susceptible to lung cancer.
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One of the most common causes of atherosclerotic vascular
disease and type 2 diabetes is metabolic syndrome (MS) (Type
2 DM). Metabolic syndrome is characterised by abdominal
obesity, insulin resistance, high blood pressure, and lipid
disorders. The metabolic syndrome's prevalence rises with age
and body weight, as well as through populations studied at the
same time. The prevalence of metabolic syndrome is 27 percent
in the United States, and the prevalence of metabolic syndrome
is growing faster in women. In Turkey, metabolic syndrome
affects 38% of the population.
Abdominal obesity
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BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is associated with several extrapulmonary systemic manifestations including metabolic and metabolic like syndrome. The objective of study was to assess prevalence of metabolic like syndrome among COPD patients. METHODS: This study was conducted from April 2017 to March 2018. Total 67 COPD patients were classied according to GOLD guideline. International Diabetes Federation (IDF) guideline was used for metabolic syndrome(MetS). RESULTS: Prevalence of MetS was 29.85%, highest (47.06%) in GOLD stage-II. If central obesity was excluded than prevalence of metabolic like syndrome was 55.27%, highest(70%) in stage-IV . CONCLUSIONS: MetS is missed in advance stages of COPD due to absence of central obesity. Therefore “Metabolic Like Syndrome” should be coined in COPD where waist circumference is not an included.
Guideline
Gold standard (test)
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OBJECTIVES: Prior research has focused on the relationship between weight change and incidence of metabolic syndrome. Change in body mass index (BMI), components of metabolic syndrome and metabolic syndrome status were investigated over 1 year of follow-up. Methods: Subjects with metabolic syndrome from a community health screening project were recruited. Logistic regression was used to analyse the disappearance or remission of metabolic syndrome during 1 year according to changes in BMI, waist circumference, triglycerides, blood pressure, high-density lipoprotein-cholesterol (HDL-C) and fasting plasma glucose (FPG). Results: The study included 490 subjects with metabolic syndrome. After 1 year, metabolic syndrome had disappeared in 30.0% (147/490) of subjects. Decreased triglycerides, blood pressure and HDL-C were significantly associated with the 1-year disappearance of metabolic syndrome, whereas BMI, waist circumference and FPG levels were not. Conclusions: Short-term weight reduction has no impact on the status of metabolic syndrome. The disappearance of metabolic syndrome was common during a 1-year follow-up. This finding might impact on the treatment and management of people with metabolic syndrome.
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Objectives
· To study the association of psoriasis and metabolic syndrome.
· To evaluate the disease activity and duration in psoriatic patients with and without metabolic syndrome.
Materials and Method: The study was conducted at MVJ Medical College, Hoskote, Bangalore. 100 newly diagnosed psoriasis patients who had not received systemic treatment 1 month before enrollment were included in study. A complete lipid profile with fasting blood glucose levels were estimated together with measurement of blood pressure and central obesity. Serum lipids were measured and fasting glucose was analysed.
Results: Among the 100 patients studied, a majority of patients were male (56%), while female patients accounted for 44%. 37 out of 100 patients had metabolic syndrome. Impaired HDL levels and fasting triglyceride were the most commonly affected components of metabolic syndrome affecting 59% and 54% respectively. There was a direct relationship between the occurrence of metabolic syndrome and extent of body surface area involved by psoriasis. Patients with psoriasis for more than 73 months had a higher occurrence of metabolic syndrome (37.84%). There was no significant correlation between PASI score and metabolic syndrome.
Interpretation and conclusion: Our study correlated with the various Indian and western studies proving an association between psoriasis and metabolic syndrome. This has important implication in aiding the dermatologist to tackle issue of metabolic syndrome in psoriatic patients and in the process prevent the cardiovascular complication that are anticipated.
Keywords: Psoriasis; metabolic syndrome; Lipid profile; Central obesity; Body surface area
Lipid Profile
Body surface area
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Homology
R gene
Conserved sequence
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Background: Metabolic syndrome is a clustering of risk factors that increase an individual’s probability of developing atherosclerotic cardiovascular disease, type 2 diabetes mellitus and all cause mortality. Since primary NAFLD has strong association with metabolic syndrome as a whole and various components of metabolic syndrome, it is being debated whether NAFLD is a hepatic component of metabolic syndrome. Hence this study was done to study the prevalence of non-alcoholic fatty liver disease in healthy individuals and in patients with metabolic syndrome and to establish a relationship between NAFLD and Metabolic syndrome.Methods: A total of 122 patients - 61 with metabolic syndrome and 61 without metabolic syndrome fulfilling inclusion and exclusion criteria who presented to the Medicine outpatient Department of Ramaiah Medical College, Bangalore, between October 2014 and September 2016 were included in the study. Baseline variables, laboratory parameters, ultrasound abdomen findings were compared between the groups.Results: Mean age of the subjects in metabolic syndrome group and non-metabolic syndrome group were 52.4±15.4 and 50.7±15.4years respectively. Mean triceps skin fold thickness (in cms) for the subjects in metabolic syndrome group and non-metabolic syndrome group were 19.16±6.1 and 7.59±2.57 respectively (P <0.05). Prevalence of fatty liver on ultrasonography in metabolic syndrome and non-metabolic syndrome were 42.62 % and 21.31% respectively. Overall prevalence of NAFLD was 31.97 %.Conclusions: Overall prevalence of NAFLD from current study was 31.97%. The prevalence of NAFLD was significantly higher in persons with metabolic syndrome than persons without metabolic syndrome.
Outpatient clinic
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Parvovirus B19 comprises three distinct genotypes (1, 2, and 3). The distribution of B19 genotypes has not before been examined in South Africa. Two hundred thirty-nine laboratory samples submitted to a diagnostic virology laboratory for parvovirus DNA detection were analyzed retrospectively. Of the 53 PCR-positive samples investigated, 40 (75.4%) were identified as genotype 1 by genotype-specific PCR or consensus NS1 PCR and sequencing and 3 (5.7%) as genotype 2 and 10 (18.9%) as genotype 3 by analysis of NS1 sequences. Furthermore, phylogenetic analysis identified two genotype 1 sequences which were distinct from the previously described genotypes 1A and 1B. Interestingly, a genotype 2 virus was detected in the serum of an 11-year-old child, providing evidence for its recent circulation. This is the first study to demonstrate the concurrent circulation of all three genotypes of B19 in South Africa and the provisional identification of a novel subtype of genotype 1. The implications of parvovirus B19 variation are discussed.
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Incidence of Metabolic Syndrome and Relative Importance of Five Components as a Predictor of Metabolic Syndrome: 5-Year Follow-up Study in KoreaThe aim of this study was to describe the incidence of metabolic syndrome and to identify five components as metabolic syndrome predictors.The final study included 1,095 subjects enrolled in a rural part of Daegu Metropolitan City, Korea for a cohort study in 2003.Of these, 762 (69.6%) subjects had participated in the repeat survey.During the five-year follow-up, incidence density was significantly higher for women than for men (men, 30.0/1,000 person-years; women, 46.4/1,000 person-years).In both men and women, incidence of metabolic syndrome showed a significant increase with increasing number of metabolic syndrome components at baseline.Compared with individuals presenting none of components at baseline, relative risks were increased 1.22 (men; 95% CI, 0.43-3.51),2.21 (women; 95% CI, 0.98-4.97)times more for individuals with one component of metabolic syndrome and 5.30 (men; 95% CI, 2.31-12.13),5.53 (women; 95% CI, 2.78-11.01)times more for those who had two components.In multivariate analysis, the most powerful risk factor for metabolic syndrome was abdominal obesity in men and low HDLcholesterol in women (adjusted relative risk, 3.28, 2.53, respectively).Consequently, finding a high risk group for metabolic syndrome according to gender and prevention of metabolic syndrome through lifestyle modification are essential.
Abdominal obesity
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