Sinusoidal hemangioma and intravascular papillary endothelial hyperplasia: Interrelated processes that share a histogenetic piecemeal angiogenic mechanism
Lucio Díaz‐FloresRicardo GutiérrezMaría-del-Pino GarcíaMiriam González‐GómezFrancisco José SáezLucio Díaz‐FloresJosé Luís CarrascoJuan Francisco Madrid
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CD31
Objective To establish the human hemangioma model in nude mice. Methods Human hemangioma endothelial cells cultured in vitro were injected hypodermically into nude mice(BALB/c nude mice). The volume of in the transplanted tumor was measured in 60 days. Samples were taken from survival tumor and stained immunohistochemically by CD31 and Ki-67 before subjected to histopathological examination. Results Hemangioma model were successfully established in nude mice and the original tumor histological characters were retained in the transplanted tumor. Conclusion Hemangioma model established in nude mice by hypodermically injection with human hemangioma endothelial cells retains all the biological characteristics of the human hemangioma and can be a good model for research on hemangioma.
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