Long-term efficacy of ultrasound-guided low power microwave ablation for the treatment of primary papillary thyroid microcarcinoma: a 3-year follow-up study
75
Citation
37
Reference
10
Related Paper
Citation Trend
Keywords:
Microwave ablation
Hematology
Microwave ablation
Ablation zone
Thermal ablation
Cite
Citations (1)
(1) Background: Percutaneous microwave ablation (MWA) is an accepted treatment of non-operative liver cancer. This study compares the ablation zones of four commercially available 2.45 GHz MWA systems (Emprint, Eco, Neuwave, and Solero) in an ex vivo porcine liver model. (2) Methods: Ex vivo porcine livers (n = 85) were obtained. Two ablation time setting protocols were evaluated, the manufacturer’s recommended maximum time and a 3 min time, performed at the manufacturer-recommended maximum power setting. A total of 236 ablation samples were created with 32 (13.6%) samples rejected. A total of 204 samples were included in the statistical analysis. (3) Results: For single-probe protocols, Emprint achieved ablation zones with the largest SAD. Significant differences were found in all comparisons for the 3 min time setting and for all comparisons at the 10 min time setting except versus Neuwave LK15 and Eco. Emprint produced ablation zones that were also significantly more spherical (highest SI) than the single-probe ablations from all other manufacturers. No statistical differences were found for ablation shape or SAD between the single-probe protocols for Emprint and the three-probe protocols for Neuwave. (4) Conclusions: The new Emprint HP system achieved large and spherical ablation zones relative to other 2.45 GHz MWA systems.
Microwave ablation
Ablation zone
Ex vivo
Microwave power
Cite
Citations (4)
Objectives To compare sizes and shapes of ablation zones resulting from hydrochloric acid infusion radiofrequency ablation (HRFA) and microwave ablation (MWA), using normal saline infusion radiofrequency ablation (NSRFA) as a control, at a variety of matched power settings and ablation durations, in an ex vivo bovine liver model.Methods A total of 90 ablation procedures were performed, using each of three modalities: NSRFA, HRFA, and MWA. For each modality, five ablation procedures were performed for each combination of power (80 W, 100 W, or 120 W) and duration (5, 10, 20, 30, 45, or 60 min). The size of ablation zones were compared using ANOVA, the Kruskal-Wallis test, or generalized linear regression.Results For ablation durations up to 30 min, mean transverse diameter (TD) after HRFA and MWA did not differ significantly (β = 0.13, p = .20). For ablation durations greater than 30 min, mean TD was significantly larger after HRFA than after MWA (β = 1.657, p < .001). The largest TD (9.46 cm) resulted from HRFA performed with 100 W power for 60 min.Conclusions Compared to MWA, monopolar HRFA with power settings of 80 W–120 W and durations of less than 30 min showed no significant difference. When duration of more than 30 min, HRFA created larger ablation zones than MWA.
Microwave ablation
Ablation zone
Ex vivo
Cite
Citations (0)
Objectives The aim of this study was to compare the differences between the ablation region and hyperechoic zones in microwave and radio frequency ablation of different tissues. Methods Microwave and radio frequency ablation were performed on fresh porcine muscle and liver with different power levels for 90 seconds. These 2 ablation methods were then performed on rabbit liver in vivo using 20 W for 60 seconds. The volumes of the ablation and hyperechoic zones were compared following different ablation methods. Results The ablation zones were significantly greater than the hyperechoic zones ( P < .05) with the same power and duration when using 2 ablation methods. The differences of the ablation and hyperechoic zones between muscle and liver tissues were significantly different ( P < .05). The difference values of the ablation and hyperechoic zones were also significantly different ( P < .05) using 2 ablation methods. Conclusions The hyperechoic zone may have underestimated the extent of ablation using a specified ablation time. In the same tissue, the hyperechoic zone could more accurately estimate the ablation zones using microwave ablation.
Microwave ablation
Ablation zone
Cite
Citations (7)
Magnetic resonance (MR)-guided microwave ablation is a well-developed technique for the treatment of tumors, especially hepatic carcinomas. However, there are no detailed reports on the changes in the MR images and histology observed after the ablation. This study aimed to dynamically map the pathological changes after ablation and the changes occurring on MR images. We performed MR-guided microwave ablation in 10 Wuzhishan pigs and obtained an MR scan immediately after ablation (0 weeks) and at 1, 2, 3, and 4 weeks after ablation. We compared the ablation assessed on MR images to tissue specimens obtained during follow-up. We found no significant difference in the ablation size between MR images and tissue specimens; the mean length and width of the ablated zone were 4.27 cm and 2.42 cm, respectively, on MR images and 4.26 cm and 2.45 cm, respectively, on specimens (P > 0.05). Immediately after ablation, carbonization and cavities were observed in the center of the ablation zone. Surrounding layer cells were necrotic but maintained their original shapes. The outermost layer was inflamed, but gradually showed fibrotic characteristics. The MR images accurately reflected the exact histological tissue changes after the ablation procedure. The dynamic imaging and pathological features of liver ablation outlined in this study will provide a useful reference for patient follow-up after MR-guided microwave ablation.
Microwave ablation
Ablation zone
Rf ablation
Cite
Citations (14)
To investigate the efficacy and safety of percutaneous microwave ablation.Twenty-six rabbits with lung VX2 tumor were randomly divided into experimental and control group. In the experimental group, microwave ablation guided by ultrasound or CT was performed based on location of the tumor. Enhanced CT scan was carried out immediately before and after the ablation for all animals. Two animals from each group were sacrificed immediately or 1 week after the ablation respectively and the others were followed for the rest of their lives.CT scan revealed that the tumor was greatly reduced or ablated after ablation. Pathological examination immediately after ablation also confirmed the tumor reduction or ablation. The survival time of the animals in the experimental group was significantly longer than that in the control group.Microwave ablation is a safe and effective method for treating lung cancer in rabbits, showing potential clinical applicability.
Microwave ablation
Cite
Citations (1)
Objective To modify the strategy and methodology of percutaneous microwave ablation for treatment of hepatocellular carcinoma(HCC),so as to simplify the therapeutic process and improve the therapeutic effect.Methods A total of 92 HCC patients with 149 nodes,with an average diameter of(4.9 ± 3.4) cm,were treated by the newly designed cooling circulation microwave electrode.Continuous ablation was used for tumors with diameters less than 6 cm and ring-shaped continuous ablation was applied for tumors with diameters more than 6 cm.Microwave ablation was used to treat tumors with diameters less than 4 cm.For tumors with diameters more than 4 cm,transcatheter arterial chemoembolization(TACE) was used before microwave ablation and nutrient arteries were given priority for ablation.Ring-shaped continuous ablation strategy and double antenna ablation strategy were adopted for tumors over 6 cm.Enhanced CT scans were performed at regular intervals to evaluate the therapeutic effect and the one-,two-and three-year survival rates were observed.Results(1) The complete necrosis rates for once,twice,and multiple ablations were 76.5%(114/149),86.6%(129/149) and 95.3%(142/149),respectively.(2) The one-,two-and three-year survival rates in our group were 94.6%(87/92),72.9%(62/85) and 61.4%(35/57),respectively.Conclusion Single microwave ablation is effective for small HCC.Double antenna ablation + first ablation of nutrient artery + TACE was effective for huge HCC.Ring shaped continuous ablation strategy can greatly reduce ablation points and simplify the ablation process,which is probably a new way for in situ complete necrosis of huge HCC.
Microwave ablation
Therapeutic effect
Ablation zone
Transcatheter arterial chemoembolization
Cite
Citations (0)
Microwave thermal ablation is under investigation for minimally invasive treatments. In the cases of small targets, such as adrenal glands, microwave thermal ablation is a valuable alternative to the traditional and more invasive treatments (e.g. surgical procedures, pharmaceutical therapies). In this work, ablation treatments are carried out on ex-vivo liver samples using a custom developed microwave ablation applicator for ablation of small targets. Ablation zones achieved with different treatment settings are analysed. The power and time settings suitable to achieve a small and well controlled ablation zone, are evaluated. Moreover, the temperature increase in different regions of the area under treatment is assessed.
Microwave ablation
Ablation zone
Ex vivo
Thermal ablation
Cite
Citations (0)
Microwave ablation
Wedge (geometry)
Ablation zone
Tumor ablation
Liver tumor
Cite
Citations (42)