Significance of venous thromboembolism in women with uterine carcinosarcoma
Koji MatsuoMalcolm S. RossDwight D. ImMerieme KlobocistaStephen BushMarian JohnsonTadao TakanoErin A. BlakeYuji IkedaMasato NishimuraYutaka UedaMasako ShidaKosei HasegawaTsukasa BabaSosuke AdachiTakuhei YokoyamaShinya SatohHiroko MachidaShiori YanaiKeita IwasakiTakahito MiyakeSatoshi TakeuchiMunetaka TakekumaTadayoshi NaganoMayu YunokawaTanja PejovićKohei OmatsuMian M.K. ShahzadJoseph L. KelleyFrederick R. UelandLynda D. Roman
20
Citation
47
Reference
10
Related Paper
Citation Trend
Keywords:
Cumulative incidence
Carcinosarcoma
Primary hepatic carcinosarcoma which has comprised of a mixture of both carcinomatous and sarcomatous elements is very rare. This tumor has been variously called as carcinosarcoma, pleomorphic large cell carcinoma, giant cell carcinoma, or undifferentiated carcinoma. Only less than 20 cases of carcinosarcoma of the liver have been reported sporadically up to now worldwide. Herein, we present a case of carcinosarcoma of the liver along with a review of the literatures.
Carcinosarcoma
Spindle cell carcinoma
Cite
Citations (2)
We describe a trichoblastic carcinosarcoma on the forehead of a 65-year-old man. This is the fifth case of trichoblastic carcinosarcoma in the literature and the first to be reported from the USA. It was successfully treated with direct excision. Trichoblastic carcinosarcoma should be distinguished from epidermal carcinosarcoma. We believe trichoblastic carcinosarcoma is an authentic carcinosarcoma derived from multiple progenitor cells whereas epidermal carcinosarcomas are derived from a single progenitor cell that undergoes epithelial to mesenchymal transition, and are better considered as sarcomatoid carcinomas.
Carcinosarcoma
Spindle cell carcinoma
Sarcomatoid Carcinoma
Cite
Citations (9)
Objective: The 2017 American College of Cardiology/American Heart Association (ACC/AHA) hypertension guidelines decreased the definition of diastolic hypertension to 80 mmHg from 90 mmHg. However, this action may not be appropriate in the elderly, considering the limited value of increased DBP in predicting future cardiovascular risk and the worse prognosis associated with significant lower DBP in the elderly. Design and method: A total of 1178 participants with SBP<130 mmHg derived from the Northern Shanghai Study, a prospective study focusing on the cardiovascular risk of the community-dwelling elderly Chinese in the northern Shanghai, China, were included. Study participants were divided into Group 1 (DBP<80 mmHg) and Group 2 (80<DBP<90 mmHg) according to DBP level. Survival analysis and Cox proportional hazard regression were used to study the future cardiovascular risk of the two groups. Results: After 5.8 years of follow-up, a total of 172 events were observed. Survival analysis showed no significant difference in the rates of the primary endpoints between two groups (14.9%vs14.0%, P = 0.80). In multiple COX proportional hazard regression, after adjusted for covariates, participants in Group 2 showed similar future cardiovascular risk (Hazard Ratio 1.05, 95% Confidence Interval 0.75-1.48, P = 0.78), as compared with Group 1. Conclusions: No increased cardiovascular risk observed in the elderly with SBP<130 mmHg and DBP between 80-90 mmHg, compared with those with DBP<80 mmHg. Therefore, it is maybe unreasonable to downregulate the definition of the diastolic hypertension in the elderly.
Cite
Citations (0)
The carcinosarcoma is a malignant mixed müllerian tumor with a highly malignant, biphasic tumor consisting of both epithelial and mesenchymal components. The presented case refers to a patient in climax with a vaginal bleeding. The Doppler echography highlights a polypoid mass, which prolapses in the cervical channel. The histopathological and immunohistochemical analysis of the surgically resected piece allowed the carcinosarcoma diagnosis. The uterine carcinosarcoma's incidence is rare, that is why this case is interesting taking in consideration the biphasic pattern of the tumor.
Carcinosarcoma
Cite
Citations (7)
Cumulative incidence
Cord blood
Cite
Citations (31)
Carcinosarcoma
Sarcomatoid Carcinoma
Spindle cell carcinoma
Cite
Citations (0)
Abstract A case of primary endobronchial carcinosarcoma with predominant spindle cell squamous carcinoma is described. The spindle cell component has not been previously reported as occurring in pulmonary carcinosarcomas. We suggest that this variety of carcinosarcoma closely resembles sarcoma of the lung histologically and emphasize that a distinction between the two neoplasms is important in view of the generally good prognosis of endobronchial carcinosarcomas.
Carcinosarcoma
Component (thermodynamics)
Spindle cell carcinoma
Cite
Citations (9)
Carcinosarcoma is a malignant tumour that has carcinomatous and sarcomatous components occurring rarely in the stomach with only a handful of case reports, mainly from Japan. We report a case of carcinosarcoma in a fifty-two-year-old female with clinical and histopathological features. The patient underwent complete workup followed by surgical resection. Macroscopically, the tumour was large and ulcerating. Microscopically, it was a carcinosarcoma with myogenic differentiation. Immunohistochemical analysis was done, which led to the diagnosis of gastric carcinosarcoma. Carcinosarcoma can mimic an adenocarcinoma clinically, and making a diagnosis on the basis of endoscopy or radiology alone is not possible. Our case report highlights the importance of immunohistochemical analysis in the diagnosis of gastric carcinosarcoma.
Carcinosarcoma
Cite
Citations (1)
Background Although most people with relapsing onset multiple sclerosis (R-MS) eventually transition to secondary progressive multiple sclerosis (SPMS), little is known about disability progression in SPMS. Methods All R-MS patients in the Cardiff MS registry were included. Cox proportional hazards regression was used to examine a) hazard of converting to SPMS and b) hazard of attaining EDSS 6.0 and 8.0 in SPMS. Results 1611 R-MS patients were included. Older age at MS onset (hazard ratio [HR] 1.02, 95%CI 1.01–1.03), male sex (HR 1.71, 95%CI 1.41–2.08), and residual disability after onset (HR 1.38, 95%CI 1.11–1.71) were asso- ciated with increased hazard of SPMS. Male sex (EDSS 6.0 HR 1.41 [1.04–1.90], EDSS 8.0 HR 1.75 [1.14–2.69]) and higher EDSS at SPMS onset (EDSS 6.0 HR 1.31 [1.17–1.46]; EDSS 8.0 HR 1.38 [1.19–1.61]) were associated with increased hazard of reaching disability milestones, while older age at SPMS was associated with a lower hazard of progression (EDSS 6.0 HR 0.94 [0.92–0.96]; EDSS 8.0: HR 0.92 [0.90–0.95]). Conclusions Different factors are associated with hazard of SPMS compared to hazard of disability progres- sion after SPMS onset. These data may be used to plan services, and provide a baseline for comparison for future interventional studies and has relevance for new treatments for SPMS RobertsonNP@cardiff.ac.uk
Cite
Citations (0)
The hazard ratio and median survival time are the routine indicators in survival analysis. We briefly introduced the relationship between hazard ratio and median survival time and the role of proportional hazard assumption. We compared 110 pairs of hazard ratio and median survival time ratio in 58 articles and demonstrated the reasons for the difference by examples. The results showed that the hazard ratio estimated by the Cox regression model is unreasonable and not equivalent to median survival time ratio when the proportional hazard assumption is not met. Therefore, before performing the Cox regression model, the proportional hazard assumption should be tested first. If proportional hazard assumption is met, Cox regression model can be used; if proportional hazard assumption is not met, restricted mean survival times is suggested.风险比（hazard ratio，HR）和中位生存时间是生存分析时的常规分析和报告指标。本文简要介绍了HR和中位生存时间的关系以及比例风险假定在这两者之间的作用，分析了检索出的58篇文献中的110对风险比和中位生存时间比的差异，并通过实例阐明了产生这种差异的原因。结果表明，在不满足比例风险假定时，Cox回归模型计算得到的风险比是不合理的，且与中位生存时间之比不等价。因此，在使用Cox回归模型前，应先进行比例风险假定的检验，只有符合比例风险假定时才能使用该模型；当不符合比例风险假定时，建议使用限制性平均生存时间。.
Cite
Citations (0)