P4935Coronary artery disease underlies most sports-related sudden cardiac arrest in the general population
Ardalan SharifzadehganNicole KaramWulfran BougouinVictor WaldmannFlorence DumasKumar NarayananDaniel JostBertrand LudesNadia AïssaouiFrankie BegantonLionel LamhautNicolas DeyeAlain CariouXavier JouvenÉloi Marijon
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1040 Sudden Cardiac Death and ICD diac condition in 43% of families.The systematic use of AjPt with high RPLs increases substantially the yield of BrS.Keywords:
Sudden cardiac arrest
Apical hypertrophic cardiomyopathy (HCM) is considered to have a benign prognosis in terms of cardiovascular mortality. This serial case report aimed to raise awareness of ventricular fibrillation (VF) and sudden cardiac death (SCD) in apical HCM.Here we describe two rare cases of apical HCM that presented with documented VF and sudden cardiac collapse. These patients were previously not recommended for primary prevention using implantable cardioverter-defibrillator (ICD) therapy based on current guidelines. However, both received ICD therapy for the secondary prevention of SCD.These cases illustrate serious complications including VF and aborted sudden cardiac arrest in apical HCM patients who are initially not candidates for primary prevention using ICD implantation based on current guidelines.
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Heart disease is a major cause of death in industrialized nations, with approximately 50% of these deaths attributable to sudden cardiac arrest. If patients at high risk for sudden cardiac arrest can be identified, their odds of surviving fatal arrhythmias can be significantly improved through prophylactic implantable cardioverter defibrillator placement. This review summarizes the current knowledge pertaining to surface electrocardiogram (ECG) predictors of sudden cardiac arrest.We conducted a literature review focused on methods of predicting sudden cardiac arrest through noninvasive electrocardiographic testing.Several electrocardiographic-based methods of risk stratification of sudden cardiac arrest have been studied, including QT prolongation, QRS duration, fragmented QRS complexes, early repolarization, Holter monitoring, heart rate variability, heart rate turbulence, signal-averaged ECG, T wave alternans, and T-peak to T-end. These ECG findings have shown variable effectiveness as screening tools.At this time, no individual ECG finding has been found to be able to adequately stratify patients with regard to risk for sudden cardiac arrest. However, one or more of these candidate surface ECG parameters may become useful components of future multifactorial risk stratification calculators.
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Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD are caused by coronary artery disease and approximately 40% of cardiac arrests are unexplained. Inherited arrythmias and cardiomyopathies are important contributors to SCA and SCD. Identifying an inherited condition after such an event not only has important ramifications for the individual, but also for relatives who may be at risk for the familial condition. This review will provide an overview of inherited cardiovascular disorders than can predispose to SCA/SCD, review the diagnostic evaluation for an individual and/or family after an SCA/SCD, and discuss the role of genetic testing.
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Abstract Sudden cardiac death is a leading cause of death worldwide. That is the reason it requires more focus on predicting the risk and identifying susceptible candidates to optimize risk and prevent the catastrophic events like sudden cardiac arrest (SCA) and sudden cardiac death. Role of cardiopulmonary resuscitation (CPR) is vital in such events. Several measures have been taken all over the world to make every person aware of SCA and cardiac compressions only CPR. Immediate intervention and advance cardiac life support requires for successful outcome. In this review we have studied the etiology, predictors, and treatment of sudden cardiac death.
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Genetic Mutation in Korean Patients of Sudden Cardiac Arrest as a Surrogating Marker of Idiopathic Ventricular ArrhythmiaMutation or common intronic variants in cardiac ion channel genes have been suggested to be associated with sudden cardiac death caused by idiopathic ventricular tachyarrhythmia.This study aimed to find mutations in cardiac ion channel genes of Korean sudden cardiac arrest patients with structurally normal heart and to verify association between common genetic variation in cardiac ion channel and sudden cardiac arrest by idiopathic ventricular tachyarrhythmia in Koreans.Study participants were Korean survivors of sudden cardiac arrest caused by idiopathic ventricular tachycardia or fibrillation.All coding exons of the SCN5A, KCNQ1, and KCNH2 genes were analyzed by Sanger sequencing.Fifteen survivors of sudden cardiac arrest were included.Three male patients had mutations in SCN5A gene and none in KCNQ1 and KCNH2 genes.Intronic variant (rs2283222) in KCNQ1 gene showed significant association with sudden cardiac arrest (OR 4.05).Four male sudden cardiac arrest survivors had intronic variant (rs11720524) in SCN5A gene.None of female survivors of sudden cardiac arrest had SCN5A gene mutations despite similar frequencies of intronic variants between males and females in 55 normal controls.Common intronic variant in KCNQ1 gene is associated with sudden cardiac arrest caused by idiopathic ventricular tachyarrhythmia in Koreans.
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