Poly(lactic-co-glycolic acid)(PLGA)/TiO 2 nanotube bioactive composite as a novel scaffold for bone tissue engineering: In vitro and in vivo studies
Hossein EslamiHamidreza Azimi LisarTahereh Sadat Jafarzadeh KashiMohammadreza TahririMojtaba AnsariTohid RafieiFarshid BastamiAlireza Shahin‐ShamsabadiFatemeh Mashhadi AbbasLobat Tayebi
60
Citation
73
Reference
10
Related Paper
Citation Trend
Keywords:
PLGA
Glycolic acid
Current treatments of craniosynostosis rely on the application of metal springs for cranial bone deviation. However, those metal springs demand a second surgical procedure for their removal. An attractive alternative would be the substitution of metal for bioresorbable polymers in the composition of the springs. The addition of poly(isoprene), PI, to poly(lactic-co-glycolic acid), PLGA, produces a polymeric blend with partial miscibility and distinct mechanical behavior that may benefit the patient recover. It is necessary to compare the histotoxicity of PLGA/PI to that presented by PLGA. In order to verify the histological behavior of the blend, 46 male Wistar rats (Rattus norvegicus, albino strain) underwent implantation of PLGA or PLGA/PI in the skull and were allocated into subgroups by timing of euthanasia (15, 30, 60, or 90 days). After euthanasia, the skull was removed and the histotoxicity was assessed histopathologically. The PLGA/PI blend showed greater histotoxicity in animals euthanized at 60 days, although in this period the histotoxicity of the PLGA/PI blend was similar to that of the PLGA copolymer at 15 days. Despite the instability of histological response, presented in different periods of observation, the results obtained in long-term show that the material has high potential for studies in craniosynostosis treatment.
Glycolic acid
PLGA
Isoprene
Miscibility
Cite
Citations (7)
Poly(lactic-co-glycolic acid) (PLGA) is the most often used synthetic polymer within the field of bone regeneration owing to its biocompatibility and biodegradability. As a consequence, a large number of medical devices comprising PLGA have been approved for clinical use in humans by the American Food and Drug Administration. As compared with the homopolymers of lactic acid poly(lactic acid) and poly(glycolic acid), the co-polymer PLGA is much more versatile with regard to the control over degradation rate. As a material for bone regeneration, the use of PLGA has been extensively studied for application and is included as either scaffolds, coatings, fibers, or micro- and nanospheres to meet various clinical requirements.
Glycolic acid
PLGA
Biocompatibility
Biodegradable polymer
Cite
Citations (198)
PLGA
Glycolic acid
Biodegradable polymer
Polycaprolactone
Cite
Citations (7)
항산화와 항염증으로 잘 알려진 헤스페리딘은 디스크 재생을 위해 효과적인 지지체로 제작하기 위해 사용하였다. 지지체는 poly(lactide-co-glycolic acid) (PLGA)에 헤스페리딘(0, 3, 5, 10%)을 첨가하여 염 침출법으로 제작하였고, 섬유륜 세포(AF)를 파종한 후 세포의 변화를 연구하였다. SEM, WST 그리고 RT-PCR 분석을 통해 세포의 부착과 증식, 세포의 표현형 분석을 실시하였다. 또한 면역조직화학염색을 통하여 AF세포의 생체 내 거동을 확인하였다. 그 결과, 5% 헤스페리딘이 함유된 PLGA 지지체가 가장 좋은 세포의 형태와 생체 적합성을 보여, 디스크 재생을 위한 지지체로서의 활용 가능성을 확인하였다.
Glycolic acid
PLGA
Lactide
Cite
Citations (0)
Purpose . The purpose of this study was to investigate the feasibility of poly lactic/glycolic acid (PLGA) as a drug delivery carrier of Rho kinase (ROCK) inhibitor for the treatment of corneal endothelial disease. Method . ROCK inhibitor Y-27632 and PLGA were dissolved in water with or without gelatin (W1), and a double emulsion [(W1/O)/W2] was formed with dichloromethane (O) and polyvinyl alcohol (W2). Drug release curve was obtained by evaluating the released Y-27632 by using high performance liquid chromatography. PLGA was injected into the anterior chamber or subconjunctiva in rabbit eyes, and ocular complication was evaluated by slitlamp microscope and histological analysis. Results . Y-27632 incorporated PLGA microspheres with different molecular weights, and different composition ratios of lactic acid and glycolic acid were fabricated. A high molecular weight and low content of glycolic acid produced a slower and longer release. The Y-27632 released from PLGA microspheres significantly promoted the cell proliferation of cultured corneal endothelial cells. The injection of PLGA did not induce any evident eye complication. Conclusions . ROCK inhibitor-incorporated PLGA microspheres were fabricated, and the microspheres achieved the sustained release of ROCK inhibitor over 7–10 days in vitro. Our data should encourage researchers to use PLGA microspheres for treating corneal endothelial diseases.
Glycolic acid
PLGA
Rho kinase inhibitor
Cite
Citations (16)
Biodegradable material poly (lactic acid-glycolic acid, PLGA) has good biocompatibility and extensive application in the medicine fields such as drug delivery material, tissue engineering scaffold and surgical suture. The synthesis, properties and application of PLGA are reviewed in this paper, especially the research progress on the synthesis are introduced in detail. The future study of PLGA should be emphasized on reduce of the synthetic cost, and for this purpose the simple and practicable direct polycondensation method using lactic acid(LC) and glycolic acid(GA) as starting monomers should be paid more attention.
Glycolic acid
PLGA
Biocompatibility
Biodegradable polymer
Absorbable suture
Biocompatible material
Cite
Citations (0)
Glycolic acid
PLGA
Polylactic Acid
Biodegradable polymer
Cite
Citations (34)
Poly(lactic-co-glycolic acid) (PLGA) has been the most successful polymeric biomaterial used in controlled drug delivery systems. There are several different chemical and physical properties of PLGA that impact the release behavior of drugs from PLGA delivery devices. These properties must be considered and optimized in the formulation of drug release devices. Mathematical modeling is a useful tool for identifying, characterizing, and predicting mechanisms of controlled release. The advantages and limitations of poly(lactic-co-glycolic acid) for controlled release are reviewed, followed by a review of current approaches in controlled-release technology that utilize PLGA. Mathematical modeling applied toward controlled-release rates from PLGA-based devices also will be discussed to provide a complete picture of a state-of-the-art understanding of the control that can be achieved with this polymeric system, as well as the limitations.
PLGA
Glycolic acid
Biomaterial
Cite
Citations (346)
Surface-modified poly(lactic-co-glycolic acid) (PLGA)/poly(β-aminoester)(PBAE)nanoparticles (NPs) have shown great promise in gene delivery. In this work, the pulmonary cellular uptake of these NPs is evaluated and surface-modified PLGA/PBAE NPs are shown to achieve higher cellular association and gene editing than traditional NPs composed of PLGA or PLGA/PBAE blends alone.
PLGA
Glycolic acid
Cite
Citations (38)
Poly Lactic Glycolic Acid (PLGA) is a synthetic copolymer of lactic acid and glycolic acid. Lactic acid contains an asymmetric carbon atom, and therefore has two optical isomers: l(+) lactic acid and d(−) lactic acid. Lactic acid is present in nature as either an intermediate or an end product in carbohydrate metabolism. Glycolic acid occurs in nature to a limited extent. PLGA can be synthesized by direct poly condensation of lactic acid and glycolic acid. However, the most efficient route to obtain high-molecular weight copolymers is the ring opening polymerization of lactide and glycolide. PLGA degrades in-vivo to various innocuous products which are eliminated from the body through the Krebs cycle, primarily as carbon dioxide and water in urine. Since it offers great advantages of biocompatibility and biodegrability with adjustable properties and capable of being processed to form a variety of objects, PLGA finds extensive biomedical applications, such as sutures, implantable devices, and drug delivery systems. Recently, it has initiated to use as novel material as base material for sustained-release formulation. It is also advantageous as a carrier for imaging contrast agents. Preparation of PLGA scaffolds is one of important benchmark for tissue engineering applications and research is going on.
Glycolic acid
PLGA
Biocompatibility
Biodegradable polymer
Lactide
Biomaterial
Cite
Citations (4)