Comparison between the mechanics of the in vivo child and adult trunk during chest physiotherapy
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The aim of this study is to compare the mechanical response of the in vivo child and adult trunk during chest physiotherapy.Keywords:
Biomechanics
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Introduction to biomechanics : basic terminology and concepts -- Biomechanics of bone -- Biomechanics of articular cartilage -- Biomechanics of tendons and ligaments -- Biomechanics of peripheral nerves and spinal nerve roots -- Biomechanics of skeletal muscle -- Biomechanics of the knee -- Biomechanics of the hip -- Biomechanics of the foot and ankle -- Biomechanics of the lumbar spine -- Biomechanics of the cervical spine -- Biomechanics of the shoulder -- Biomechanics of the elbow -- Biomechanics of the wrist and hand -- Biomechanics of fracture fixation -- Biomechanics of arthroplasty -- Biomechanics of gait.
Biomechanics
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Background. Constraint-induced therapy (CIT) is effective in improving upper extremity motor function, but evidence is lacking about effectiveness grasp and trunk control. Objective. This study investigated whether distributed CIT combined with trunk restraint (dCIT + TR) benefited movement kinematics of grasping and the trunk, as well as motor ability of the upper extremity, more than dCIT alone. Methods. A total of 45 stroke participants received 2 hours of dCIT + TR, dCIT, or the dose-matched control intervention for 3 weeks. Movement kinematics, motor ability, and daily function were the outcome measures. Movement kinematics included grasping, joint range, and trunk movement at various phases of reach-to-grasp tasks. Motor ability and daily function of all participants were evaluated using the Fugl-Meyer Assessment and the Motor Activity Log. Results. Four to 5 participants in each group were not included for kinematic analysis because of their inability to grasp a can. The dCIT + TR group showed better preplanned grasping movement and less trunk motion at the early phase of the reach-to-grasp movements than the dCIT or control groups. Compared with the controls, the dCIT + TR participants showed better motor ability in the overall and distal arm scores of the Fugl-Meyer Assessment. The dCIT + TR and dCIT participants demonstrated significantly greater functional use of the affected arm. Conclusions. Administering dCIT + TR produced additional benefits by improving grasping control and reversing the compensatory trunk movement at the early phase of a reach-to-grasp movement. The use of experimental tasks beyond and within arm’s length might improve our understanding of optimal upper extremity rehabilitation.
Constraint-induced movement therapy
Motor Control
Functional movement
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Purpose: Deficits in lower-extremity function and trunk control ability have a negative impact on individuals with hemiplegia. This case report aimed to describe the effect of trunk stability exercises using proprioceptive neuromuscular facilitation (PNF) on trunk control ability, balance, and gait in a patient with hemiplegia. Methods: A 77-year-old man with hemiplegia and trunk and lower extremity impairment participated in this four-week training intervention. Results: The patient demonstrated improvements in trunk control ability, balance, and gait performance. Outcome measures (Fugl-Meyer Assessment Lower Extremity (FMA-LE), Trunk Control Test, Berg Balance Scale, Timed Up and Go test, 10 Meter Walk test) were measured before and after the training program. Conclusion: The results of this case suggest that a trunk stability exercise using a PNF program may improve trunk control ability, balance, and gait in a patient with hemiplegia.
Proprioception
Berg Balance Scale
Facilitation
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Biomechanics
Sports biomechanics
Indentation
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[Purpose] This study aimed to investigate the relationships among trunk impairment, functional performance, and muscle activity during forward reaching tasks in patients with chronic stroke. [Subjects and Methods] Twenty-three chronic stroke patients participated in this study. Trunk impairment and functional performance were evaluated using the Trunk Impairment Scale, Berg Balance Scale, Timed Up and Go Test, and 10-Meter Walk Test. All subjects were asked to perform 3 different forward reaching tasks (affected side reaching, forward reaching, and less-affected side reaching), and measurements were taken during these 3 tasks by using surface electromyography. Correlation analyses were performed to assess the relationships among trunk impairment, functional performance, and muscle activity during the forward reaching tasks. [Results] Spearman's correlation analysis revealed a strong, significant correlation between the Trunk Impairment Scale and functional performance, that was associated with balance and gait ability. During the 3 different forward reaching tasks, muscle activities of the less-affected lower extremity were significantly correlated with functional performance. [Conclusion] This study revealed the correlations among trunk impairment, functional performance, and muscle activity during forward reaching tasks in patients with chronic stroke and emphasized the importance of trunk rehabilitation.
Berg Balance Scale
Functional impairment
Motor impairment
Chronic stroke
Stroke
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In vitro determination of metabolic stability is routinely used to assess the overall metabolic liability of compounds and for prioritization for in vivo studies. If in vitro metabolic stability data could be used to reliably predict in vivo clearance (CL), it would add significant value in the selection of compounds for in vivo pharmacokinetic and pharmacology studies. We have evaluated the utility of our in vitro metabolic stability screening assay to estimate in vivo CL in the mouse. The in vitro mouse clearances (CLin vitro) of 146 structurally diverse compounds with metabolic stabilities > 30 %, were compared to mouse in vivo CL data. Approximately 45 % of the compounds showed agreement between in vivo CL and predicted CLin vitro within a 2-fold error criteria. The correlation appeared worse when correction for the extent of incorporation of plasma protein binding or both plasma and S9 bindings (i.e. ~14 % and~ 28 % agreement, respectively). Classification of the compounds into three groups based on in vivo CL (<30 mL/min/kg, 30-70 mL/min/kg, and >70 mL/min/kg) did not show any improvement between in vivo CL and predicted CLin vitro. The percentage of compounds falling within the 2-fold error criteria for low CL, moderate CL and high CL groups were 54, 31 and 24 %, respectively. In conclusion, our analysis suggests that in vitro metabolic stability data, as routinely obtained in early ADME screening protocols, does not demonstrate a strong correlation with or predictivity for, absolute in vivo CL in the mouse.
ADME
Metabolic stability
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The purpose of the present case series was to investigate whether three lower limb rehabilitation training approaches have any effects on trunk stability of persons with motor complete SCI during a 10-minute assisted walk. These trainings included electrical stimulation (ES), standing retraining (SRT), and a novel multi-modality approach that combined ES with SRT. We observed that multi-muscle ES directed at the lower limbs had a prominent, indirect effect on the upper and lower muscles of the trunk. More specifically, trunk muscle activations of the ES+SRT subject increased after training for the more distal muscles of the trunk. This study provides preliminary evidence that combining lower limb ES with SRT may provide beneficial effects in improving trunk control and stability.
Functional electrical stimulation
Core stability
Retraining
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