Mechanism and protective effect of pioglitazone pretreatment on cerebral ischemia-reperfusion injury in rats

Objective To investigate the effects of simvastatin on cerebral injury induced by ischemia reperfusion in rats and the mechanisms. Methods The model of focal cerebral ischemia reperfusion in rat was established. The activity of calpain was measured dynamically by biochemical methods. Results Simvastatin significantly decreased the injury induced by ischemia-reperfusion and reduced the calpain activity in ischemia reperfusion cortex. Conclusion Simvastatin is able to reduce the cerebral ischemia reperfusion-induced injury, which is probably associated with the decreased calpain activity.

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The Hypoglucemic Effect of the Antioxidant Drug "U-74389g" during Ischemia Reperfusion Injury in Rats

International Journal of Diabetes and Clinical Research (2015)

Constantinos Tsompos

Aim:The aim of this experimental study was to examine the effect of the antioxidant drug "U-74389G", on rat model and particularly in an ischemia -reperfusion protocol.The beneficial effects or noneffectiveness of that molecule were studied biochemically using blood mean glucose levels.Materials and methods: 40 rats of mean weight 231.875gr were used in the study.Glucose levels were measured at 60 min of reperfusion (groups A and C) and 120 min of reperfusion (groups B and D), A and B without but C and D with U-74389G administration.Results: Results were that U-74389G administration significantly decreased the predicted glucose levels by 8.57% ± 2.06% (p=0.0001).Reperfusion time non-significantly increased the predicted glucose levels by 1.71% ± 2.49% (0.4103).However, U-74389G administration and reperfusion time together significantly decreased the predicted glucose levels by 4.76% ± 1.28% (p=0.0005). Conclusion:Conclusions are that U-74389G administration interacted or not with reperfusion time has significant decreasing effect on the glucose serum levels, enabling consideration of it as a potential hypoglucemic factor.

10.23937/2377-3634/1410031

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