Comparison the endometrial parameters by three-dimensional ultrasonography and power Doppler angiography on HCG administration day between on-going pregnant women and patients suffering early spontaneous abortion after good quality embryos transfer.
Leining ChenLi HongYu-wen QiuCuihua ChenChen LuoQiu-hua LiMao-lan HuMin YuYang JieFu-qi XingChen SimeiShiling ChenXin ChenMei ZhongSong QuanYu YanHong
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The implantation process after embryo transfer depends on the embryo quality and endometrial receptivity. It is estimated that fifty to seventy-five per cent of pregnancies are lost due to a failure of implantation. There is evidence that there is an early secretion of human chorionic gonadotrophin before embryo implantation, and this secretion has been linked to an important function in angiogenesis and the inflammatory response that promotes the implantation process. Our objective was to determine the effects of intrauterine injection of human chorionic gonadotropin (hCG) before the embryo transfer in an in vitro fertilisation cycle. A prospective randomised study was conducted in Reproductive Medicine Centre PROCREA in Mexico City. Infertile patients who had a medical indication for in vitro fertilisation were studied. Two groups were included (n 210); the intervention group received an intrauterine injection of 500 IU of hCG before the embryo transfer (n 101). The control group (n 109) did not receive hCG. Comparisons were performed using a chi-square test. The clinical pregnancy rate (CPR) was our principal outcome. The implantation rate was a secondary outcome. The implantation rate was significantly higher in the hCG group compared to the control group (52.4% vs 35.7%, p 0.014). The clinical pregnancy rate was also significantly higher (50.4 vs 33.0%, p 0.010). No adverse effects were observed. The intrauterine injection of hCG before embryo transfer showed a significant increase in the clinical pregnancy rate. More clinical trials are needed to reproduce these results on this promising intervention. The live birth rate must be included in subsequent studies.
Human chorionic gonadotropin
Gonadotropin
Embryo quality
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Journal Article Consecutive triplet pregnancies following in-vitro fertilization and embryo transfer. Two case reports Get access C.R. Kingsland, C.R. Kingsland The Hallam Medical Centre, 77 Hallam StreetLondon WIN 5LR, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar S.J. Smith, S.J. Smith The Hallam Medical Centre, 77 Hallam StreetLondon WIN 5LR, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar B.A. Mason B.A. Mason The Hallam Medical Centre, 77 Hallam StreetLondon WIN 5LR, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Reproduction, Volume 4, Issue 4, 1 May 1989, Pages 473–474, https://doi.org/10.1093/oxfordjournals.humrep.a136929 Published: 01 May 1989 Article history Received: 31 October 1988 Accepted: 23 December 1988 Published: 01 May 1989
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D17 ET - After ET, 14th day β hCG If pregnancy is present, E2 ve P dose administered until placental autonomy. Muasher;1991
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Seit Anfang 1981 bieten wir geeigneten Sterilitätspatientinnen ein In-vitro-Fertilisationsprogramm als Behandlungsmöglichkeit an. Bis zum 31. 10. 1981 haben wir 36 Versuche unternommen, laparoskopisch oder bei einer zur Ovulation terminierten Laparotomie durch Follikelpunktion Oozyten zu gewinnen, um diese in vitro zu fertilisieren. Bei 18 Patientinnen entwickelten sich die fertilisierten Eizellen zu Vierbis Achtzell-Embryonen und wurden in den Uterus transferiert. Bisher haben wir zwei Schwangerschaften erzielt, die sich am 30. 11. 1981 in der 10. bzw. 19. Woche befanden.
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The purpose of this study was to evaluate whether the dynamics of endometrial stripe thickness during gonadotropin-releasing hormone (GnRH) antagonist pituitary downregulation in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles are related to implantation and pregnancy outcomes.This retrospective cohort study evaluated 115 conventional IVF/ICSI cycles. All patients underwent ovarian stimulation with gonadotropins and the GnRH antagonist ganirelix acetate. The endometrial stripe was measured transvaginally daily from the day of initial GnRH antagonist administration to the day of the human chorionic gonadotropin (hCG) trigger and then transabdominally on the day of embryo transfer. We created 5 categories (0-4) of endometrial thickness variation, considering significant a daily variation of 1.5 mm. Our aim was to predict whether the endometrial thickness dynamics or morphologic characteristics were related to the duration of ovarian stimulation, duration of ganirelix use, or estradiol levels during ovarian stimulation and whether they would influence implantation and pregnancy rates.No relationship was found between the duration of ovarian stimulation, duration of ganirelix use, and estradiol level (expressed as the area under the curve), and endometrial thickness dynamics or morphologic characteristics. Despite a thinner endometrial thickness in 37% of the cycles on the day of the hCG trigger compared with the beginning of GnRH antagonist stimulation, there was no correlation between endometrial dynamics and pregnancy outcomes. There was, instead, a positive relationship between a trilaminar endometrial morphologic pattern with a positive pregnancy test result, successful implantation, and ongoing pregnancy (P < .05).Despite a net decrease in thickness in almost 50% of cases, endometrial dynamics did not correlate with pregnancy outcomes. Conversely, a trilaminar endometrial morphologic pattern on the day of embryo transfer was positively related to pregnancy outcomes.
Human chorionic gonadotropin
Gonadotropin
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