P09.60 Determination of different tumors regions by quantitative MRI methods in glioblastoma
0
Citation
0
Reference
10
Related Paper
Abstract:
BACKGROUND: Recently, many innovative MRI methods were generated to visualize different physiological and tumor biological aspects like the tumor microenvironment including the tumor oxygenation. In this study we want to generate diverse reference ranges of tumor regions in untreated glioblastoma patients. Standard values of quantitative MR imaging in these patients do not yet exist. METHODS: In this prospective study, we included 52 patients with a cerebral mass lesion who are radiologically suspicious for glioblastoma (GBM). Before patients underwent histological validation they received a conventional and a quantitative MRI (qMRI). The diagnosis was proven by stereotactic biopsy. Different areas of the presumably normal brain or the tumor were selected and the average value of the certain area was detected. Results: Mean values of quantitative T1 und T2 maps in milliseconds (ms) were determined in 35 histopathologically proven GBM cases. Therefore, reference ranges for different areas (enhancing tumor, peritumoral edema, necrosis and contralateral, healthy control region) were recorded. We detected significantly prolonged qT1 and qT2 relaxation times in all tumor regions compare to the healthy control region. CONCLUSION: With our data different regions of the tumor are distinguishable by quantitative values. Correlations with histopathologic analysis are ongoing.Keywords:
Stereotactic biopsy
Brain tumor
Stereotactic biopsy
Core biopsy
Breast biopsy
Table (database)
Cite
Citations (1)
Neurosurgeons have preferred to perform the stereotactic biopsy for pathologic diagnosis when the intracranial pathology located eloquent areas and deep sites of the brain.To get a higher ratio of definite pathologic diagnosis during stereotactic biopsy and develop practical method.We determined at least two different target points and two different trajectories to take brain biopsy during stereotactic biopsy. It is a different way from the conventional stereotactic biopsy method in which one point has been selected to take a biopsy. We separated our patients into two groups, group 1 (N=10), and group 2 (N= 19). We chose one target to take a biopsy in group 1, and two different targets and two different trajectories in group 2. In group 2, one patient underwent craniotomy due to hemorrhage at the site of the biopsy during tissue biting. However, none of the patients in both groups suffered any neurological complication related biopsy procedure.In group 1, two of 10 cases, and, in group 2, fourteen of 19 cases had positive biopsy harvesting. These results showed statistically significant difference between group 1 and group 2 (P<0.05).Regarding these results, choosing more than one trajectories and taking at least six specimens from each target provides higher diagnostic rate in stereotaxic biopsy taking method.
Stereotactic biopsy
Brain biopsy
Cite
Citations (9)
CT-guided stereotactic biopsy is now an accepted method of tissue sampling in intracranial mass lesions but many surgeons still practise freehand burrhole biopsy. This study compares two groups of patients who had either stereotactically guided (n = 153) or freehand (n = 217) biopsy. Stereotactic biopsy has a lower incidence of both mortality (2.6%) and morbidity (1.3%) than freehand (7.8 and 7.8%) while diagnostic accuracy is 92.1 and 64.9%, respectively. The success rate for stereotactic biopsy is independent of the size and depth of the lesion while freehand biopsy is most successful for large, superficial lesions but its success never exceeds 88%. The stereotactic technique is superior to the freehand for all intracranial biopsies regardless of size or site.
Stereotactic biopsy
Brain biopsy
Stereotaxy
Cite
Citations (34)
One hundred three patients underwent stereotactic breast biopsy with an 18-, 16-, or 14-gauge cutting needle and a biopsy gun. After biopsy, a localization wire was placed and surgical biopsy performed. There was agreement of the histologic results in 89 cases (87%) including 14 of 16 cancers (87%) (kappa = 0.806). The gun biopsy yielded the correct diagnosis in four cases involving a lesion (including one cancer) that was missed at the surgical biopsy. Nine cases in which the lesion was missed at gun biopsy can be related to insufficient needle size, the greater difficulty in using one of the two stereotactic devices, and early inexperience with the technique. A 14-gauge needle was used in the last 29 biopsies, the results of which agreed with the surgical pathologic findings in 28 cases (97%). With greater experience, stereotactic-guided large-gauge automated percutaneous biopsy may prove to be an acceptable alternative to surgical biopsy in women with breast masses suspected at mammography.
Stereotactic biopsy
Breast biopsy
Cite
Citations (364)
Stereotactic Histologic Biopsy with Patients Prone: Technical Feasibility in 98% of Mammographically Detected LesionsRoger J. Jackman1 and Francis A. Marzoni, Jr.2Audio Available | Share
Stereotactic biopsy
Breast biopsy
Cite
Citations (61)
A 49-year-old woman underwent 11-gauge vacuum-assisted stereotactic biopsy of a cluster of indeterminate calcifications in the left breast. A clip was deployed accurately at the biopsy site as confirmed on mammograms obtained immediately after biopsy. The patient returned 8 days later for additional stereotactic biopsies of the left breast. Repeat mammograms revealed that the clip deployed at the original biopsy site had migrated 5 cm inferiorly. © RSNA, 2003
Stereotactic biopsy
Breast biopsy
Cite
Citations (21)
Non palpable breast lesion can be biopsied with the guiding under the B Ultrasound and stereotactic system.Fine Needle Aspiration (FNA) and Core needle biopsy (CNB) are currently two of the most comman needle biopsy methods for those lesion.Stereotactic core needle biopsy is utilized as screening for mammographic abnormalities because of high diagnostic sensitivity and avoidance of open biopsy for benign lesion.Furthermore, they also allow treatment planning before surgery.But for the histologic underestimation and some missed case,needle breast biopsy could not completely replace excisional biopsy.More attention should be paid to patient selection and rebiopsy indication.
Stereotactic biopsy
Breast biopsy
Core biopsy
Needle biopsy
Open biopsy
Cite
Citations (0)
Stereotactic biopsy
Core biopsy
Breast biopsy
Cite
Citations (14)
Stereotactic biopsy
Breast biopsy
Cite
Citations (6)
Stereotactic biopsy
Breast biopsy
Core biopsy
Cite
Citations (7)