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    An open clinical study of tebipenem pivoxil in children with acute otitis media and acute upper respiratory tract infection (phase II)
    Nihon Kagaku Ryōhō Gakkai zasshi/Nihon Kagaku Ryoho Gakkai zasshi (2009)
    Keisuke SunakawaNoboru YamanakaSatoshi IwataKyoichi TotsukaYoshio AizawaSeiji HoriN IwaiKimiko Ubukata
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    Keywords:
    Acute Otitis Media
    Respiratory tract
    Topics:
    Antibiotics Pharmacokinetics and Efficacy
    Pneumonia and Respiratory Infections
    Drug-Induced Adverse Reactions
    The quinolones in otitis media and upper respiratory infections
    Milestones in drug therapy (2003)
    Eugene LeibovitzRon Dagan
    Upper respiratory tract infections are a frequent cause of illness. In children, acute otitis media (AOM) is the most common illness for which children receive medical attention. In adults, 20 million cases of bacterial sinusitis are reported yearly and the disease represents the fifth most common diagnosis for which an antibiotic is prescribed [1].
    Acute Otitis Media
    Respiratory tract
    Respiratory illness
    Citations (1)
    A comparative study of the effect of Ofloxacin on acute otitis media and the acute exacerbation of chronic otitis media between oral medicine and otic solution
    OTOLOGIA FUKUOKA (1994)
    Masafumi SakagamiTakayuki ShiraishiTakeshi KuboToru MatsunagaTatsuji Matsumoto
    Acute Otitis Media
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    PubMed (1976)
    Lindeman Hh
    Acute Otitis Media
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    Concomitant Rhinosinusitis is a Risk Factor for Refractory Acute Otitis Media in Children
    Practica oto-rhino-laryngologica Suppl (2014)
    Noboru YamanakaAkihiro UchizonoYoshifumi UnoKeiko KanesadaShoichi Sawada
    We evaluated the risk factors for refractory otitis media in children and factors related to the clinical efficacy of antimicrobial treatment using tebipenem pivoxil (TBPM-PI). Multivariate logistic regression analysis revealed that “group living” (adjusted odds ratio; 6.2, 95%CI; 1.6-24.7, P=0.010), “age under 2 years old” (adjusted odds ratio; 4.2, 95%CI; 1.5-11.3, P=0.005), and “concomitant rhinosinusitis” (adjusted odds ratio; 2.9, 95%CI; 1.1-8.1, P=0.039) were significant risk factors for refractory otitis media. In 96 cases of acute otitis media (AOM) with the risk factors of refractoriness, TBPM-PI showed clinical efficacies with 100% for patients with one of the three risk factors and with 85% for patients with two or more of the risk factors. Multivariate logistic regression analysis revealed that “concomitant rhinosinusitis” (adjusted odds ratio; 4.4, 95%CI; 1.5-13.1, P=0.008) was a significant factor related with the poor clinical efficacy of TBPM-PI treatment for AOM.Based on the results clinicians providing medical care for pediatric AOM should keep the risk factors of refractoriness in mind when selecting an appropriate treatment strategy.
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    Refractory (planetary science)
    Citations (1)
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    Kirk J. FleischerW SchleissingH HilberHöring Fo
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    Acute Otitis Media in Sweden
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    Kaj LundgrenLeif Ingvarsson
    Exudate
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    Schmitt Hj
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    COME in preschool-aged children
    Ilya Petrou
    A recent study found that pathogen exposure, upper respiratory tract infection (URI), and nasal obstruction all were associated with chronic otitis media with effusion (COME) in preschool-aged children, underscoring the need for improved methods in pathogen transmission prevention in this patient population.
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    Azithromycin vs. Cefaclor for Acute Otitis Media
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    Effective antibiotic treatment for acute otitis media must eradicate the causative organisms from the middle-ear fluid. Recently, increased prevalence
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    Ouyang Shao-j
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