Cytomegalovirus Infection in Heart-Transplant Recipients in a Central Region of Italy
Margherita D’AlessandroKatia FalascaDelia RacciattiPompea ZingarielloP. CacciatoreA ScarinciA. CeccomanciniGabriele Di GiammarcoEligio PizzigalloJacopo Vecchiet
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Abstract:
Cytomegalovirus (CMV) infection occurs very often after solid organ transplantation and is often a life-threatening complication of long-term immunosoppressive therapy. Actually it is unknown which type of drug is indicated to control the infection in immunocompromised patients. We studied 10 consecutive patients who had undergone heart-transplantation and in which CMV infection was the commonest post-transplant infectious disease. Our results suggest a careful monitoring of IgG seropositivity in heart transplant patients, especially when it is not possible to know the serum status of the donor.Keywords:
Cytomegalovirus
Cytomegalovirus (CMV) is the most common infection after organ transplantation; it can be a major cause of morbidity, mortality. Optimal prevention, diagnosis, and treatment of active CMV infection enhance transplant outcomes. But, the management of CMV varies considerably among transplant centers. We described the incidence, clinical profile, outcome, and risk factors for the development of CMV infection among renal transplant recipients.
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The general characteristics of cytomegalovirus (CMV), one of a member of the family Herpesviridae has been described. Epidemiologic findings, especially CMV infection rates in normal individuals and different risk groups, as well as sources of infection have been discussed. The article presented clinical syndromes associated with CMV infection in normal host, infants, blood products and allograft recipients, HIV-positive and undergoing immuno-suppressive therapy patients.
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Cytomegalovirus (CMV) is the most common viral infection after solid organ transplantation. Great innovations have been achieved in terms of CMV screening, antiviral prophylaxis and antiviral treatment. This study shows short term (1 year post-transplantation) and long term (10 years post-transplantation) outcomes of CMV infection/disease after kidney transplantation.
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A case of isolated necrotizing cytomegalovirus (CMV) oophoritis disclosed only by necropsy studies in a patient with AIDS, is described. This unusual case report is discussed with a review of the literature dealing with CMV involvement of genital organs in the immunocompromised host, and in patients with HIV infection and AIDS.
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Cytomegalovirus (CMV) is the most common cause of congenital infection and complicates approximately 1% of all live births. Primary maternal CMV infection carries a 30% to 40% risk of vertical transmission to the fetus. In cases where maternal CMV infection is suspected, it is important to evaluate the risk to the fetus to provide appropriate counseling and guidance to parents. This article reviews the published literature and summarizes current diagnostic and management recommendations to help answer the question, should all women be screened for CMV infection in pregnancy?
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Late cytomegalovirus (CMV) infection in renal allograft recipients is uncommon. The treatment of CMV infection is controversial, with numerous claims of successful treatment with different drugs. We report the successful use of acyclovir in a serious case of CMV infection occurring in a young woman 3 1/2 years after a renal transplant. This result is encouraging and supports the future use of acyclovir in the treatment of CMV infection in this and other settings.
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Objective To explore the clinical manifestation and treatment methods for pulmonary cytomegalovirus infection in kidney transplantation patients. Methods The clinical data of 8 patients with pulmo-nary infection were retrospectively analyzed. Results The 8 patients suffered from pulmonary cytomegalovirus infection in 3 ～ 4 months after operation. Three of them had co-infection of different pathogen ( bacteria and fungus). 4 patients were cured,and 4 died. Conclusion Pulmonary cytomegalovirus infection showed delitescence in earlier period. The accurate therapy would improve the cure rate of pulmonaty infection.
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