The fate of mesenchymal stem cells after subconjunctival implantation
0
Citation
0
Reference
20
Related Paper
Cite
Therapeutic Interaction of Systemically-Administered Mesenchymal Stem Cells with Peri-Implant Mucosa
Objectives The objective of this study was to investigate the effect of systemically transplanted mesenchymal stem cells (MSCs) on the peri-implant epithelial sealing around dental implants. Materials and Methods MSCs were isolated from bone marrow of donor rats and expanded in culture. After recipient rats received experimental titanium dental implants in the bone sockets after extraction of maxillary right first molars, donor rat MSCs were intravenously transplanted into the recipient rats. Results The injected MSCs were found in the oral mucosa surrounding the dental implants at 24 hours post-transplantation. MSC transplantation accelerated the formation of the peri-implant epithelium (PIE)-mediated mucosa sealing around the implants at an early stage after implantation. Subsequently, enhanced deposition of laminin-332 was found along the PIE-implant interface at 4 weeks after the replacement. We also observed enhanced attachment and proliferation of oral mucous epithelial cells. Conclusion Systemically transplanted MSCs might play a critical role in reinforcing the epithelial sealing around dental implants.
Oral mucosa
Cite
Citations (17)
Mesenchymal stem cells (MSCs) are multipotent adult stem cells, prototypically found in the bone marrow, which are undergoing investigation as a cell-based therapeutic for several clinical disorders. This potential of MSCs is due to their ability for self renewal, to be immune privileged and immunosuppressive, and to give rise to different specialized cells from the mesoderm lineage, such as adipocytes, chondrocytes, osteocytes, cardiocytes, or myocytes, and from nonmesoderm lineage, such as neurons (ectoderm) or hepatocytes (endoderm). Several animal studies (e.g. swine) have shown that bone marrow derived MSCs restore cardiac function and regenerate cardiac tissue in settings of both acute and chronic injury. Based on rigorous preclinical results, there are numerous ongoing Phase I/II clinical trials addressing the safety, cell dose, delivery technique, and efficacy of MSCs in patients with chronic heart failure. Here we describe the procedures for the isolation, expansion and cryopreservation of MSCs from harvested bone marrow for cardiac delivery.
Cite
Citations (5)
Cite
Citations (1)
Cite
Citations (1)
2019-20 coronavirus outbreak
Cite
Citations (0)
Cite
Citations (0)
Gelatin
Cite
Citations (7)
Cite
Citations (0)
Cite
Citations (1)