MA12.09 Comparative Histological Subtype Analysis of Lung Adenocarcinoma Tumor and Metastatic Lymph Nodes and the Prognostic Impact
Shaohua LuTakashi EguchiZachary E. TanoDaniela MolenaDavid R. JonesWilliam D. TravisPrasad S. Adusumilli
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Lymphovascular invasion
Primary tumor
Adjuvant Therapy
Surgical oncology
Clinical Oncology
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This article presents supplementary data for the research article by Yotsukura et al. entitled "Prognostic impact of cancer-associated active fibroblasts and invasive architectural patterns on early-stage lung adenocarcinoma" [1], which presented the postoperative prognosis for early-stage lung adenocarcinoma categorized according to histological findings. We included data of 1,032 resected cases of lung adenocarcinoma, which consisted of pathological stage IA invasive cancer and adenocarcinoma in situ resected at National Cancer Center Hospital, Tokyo, Japan, between 2007 and 2012. A pathological review was performed to assess total tumor size, size of invasion, histological subtype, lymphovascular invasion, and presence of cancer-associated active fibroblast (CAF). Tumor recurrence and overall survival were retrospectively recorded. Of the included cases, 166 (16.1%), and 866 (83.9%) were adenocarcinoma in situ and pathological stage IA, respectively. Pathological stage IA adenocarcinoma was further classified based on the histologial subtype and the presence of CAF. This data set may be useful for analyzing the postoperative prognosis of early-stage lung adenocarcinoma, in combination with detailed pathological findings including size of invasion, histological subtype, and presence of CAF.
Lymphovascular invasion
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Objective:To explore the factors affecting the pathological diagnosis of lung mass.Methods:A retrospective analysis of 148 cases of mass distribution in lung was performed.The cases were divided into tumor group and non-tumor group according to the results of pathological diagnosis.Results:The incidence of lung cancer was higher in patients above the age of 60 than that under 60(P0.01);but the positive rate had not significant difference in gender or distribution of lung mass.Conclusions:The highest incidence of lung cancer is observed in patients with lung mass above the age of 60.
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Objective To discuss the value of lung cancer tumor marker levels change before and after chemotherapy.Methods 228patients with clinically diagnosed patients with lung cancer were analyzed, all passed two cycles of chemotherapy,and observed the tumor markers changes of CEA,NSE and CYFRA21-1before three different types of chemotherapy,and combine with the changes of Chest CT,and evaluate the curative effect.Results The positive rate of CEA,NSE,CYFRA21-1is significantly higher respectively in lung adenocarcinoma,small cell lung cancer(SCLC),squamous carcinoma group than other types of lung cancer(P 0.05).After two weeks′chemotheraphy,CEA was significantly higher with adenocarcinoma than other subtypes of lung cancer(P 0.05);The level of NSE was significantly higher in patients with SCLC than other subtypes of lung cancer(P 0.05);The level of CYFRA21-1was significantly higher in patients with squamous carcinoma than other subtypes of lung cancer(P 0.05);The level of CEA was dropped significantly after chemotherapy in PR patients with adenocarcinoma and increased obviously in PD patients with adenocarcinoma;The level of NSE was dropped significantly before chemotherapy in PR patients with SCLC;The level of CYFRA21-1was dropped significantly before chemotherapy in PR patients with squamous carcinoma.Conclusion The serum determination of CEA,NSE, and CYFRA21-1were conducive to judge the types of tumor cell.The serum change after chemotherapy was closely correlated with the therapeutic effect.
Squamous carcinoma
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Wedge resection
Lymphovascular invasion
Resection margin
Adjuvant Therapy
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Primary tumors metastasizing to the tongue are extremely rare. There is a 1% rate of metastasis to the oral cavity from other primary sites, most commonly the lung, breast, skin, gastrointestinal tract, and liver. There is a 1.6% rate of primary lung cancer metastasized to the tongue. We describe a patient with adenocarcinoma of the lung who developed a metastatic lesion on the tongue. A 71-year-old Taiwanese male was diagnosed with adenocarcinoma of the lung at stage IV (cT4N2M1a, stage IV [lung-to-lung metastasis]) with a tongue tumor. The tumor was painful, palpable, and firm, measuring around 1 x 1 x 1 cm^3 on the anterior part of the tongue. There was no cervical lymphadenopathy. The tumor was thought to be a metastasis of the lung adenocarcinoma. The tongue lesion was excised and revealed adenocarcinoma. The histology of the specimen was consistent with that of the previous lung cancer, so he was considered to have had tongue metastasis from adenocarcinoma of the lung (right upper lung, cT4N2M1b, stage IV [lung-to-lung and tongue metastasis]).
Primary tumor
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The spread of tumor cells from a primary neoplasm to distant organs, resulting in the growth of mA©tastases,is the most devastating aspect of cancer. Although our understanding of the pathogenesis of metastasis has increased considerably, no great improvements in the treatment of metastatic disease produced by the major solid tumors have occurred. Advances in surgical techniques and adjuvant therapies have not changed the fact that most deaths from cancer are caused by metastasis. In part, this failure is due to the fact that by the time of diagnosis, and certainly in clinically advanced lesions, malig nant neoplasms and mA©tastases contain multiple cell popula tions with a wide range of biological characteristics. The barrier to therapy that biological heterogeneity of metastatic lesions presents can be exacerbated by the anatomic location of the lesions, since often mA©tastases in one organ will be susceptible to therapy whereas those in other organs will be resistant. Understanding the mechanisms responsible for the process of cancer metastasis, for the origin of mA©tastases, and for the development of biological diversity (heterogeneity) in mA©tas tases is an urgent goal of cancer research. Only from this new understanding can the design of therapy for metastatic disease be improved. The Eighth Annual Sapporo Seminar on Cancer Progression and Metastasis focused on such recent data. The
Primary tumor
Adjuvant Therapy
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OBJECTIVE: To analyze the clinical pathology characteristic of patients with lung neoplasms.METHODS: A total of 1 729 patients with lung neoplasms in cancer hospital,chinese academy of medical sciences from Jan.2008 to Dec.2008 were analyzed retrospectively including residence,age,gender,pathological types and HBV results.RESULTS: There were 1 179 male patients and 550 female patients in 1 729 lung neoplasms patients,including 1 474 cases of lung cancer patients,228 were benign and 27 cases of patients with unclear diagnosis.Totally 95.72% of the patients from the northern region of China.As to the pathological types,656 patients(44.50%) were adenocarcinoma;squamous cell carcinoma and SCLC,respectively,accounting for 33.24% and 9.50%.And 68.29% of female lung cancer patients with adenocarcinoma.The most common pathological types of benign patients were inflammatory mass,totally 67 cases(29.39%).A total of 55.29%(941/1 702) of lung lesions of all lung neoplasms patients were in right lung,especially the right upper lobe.The HBV infection rate was relatively stable at 4.92% in lung neoplasms patients and didn't matter with the pathological types.CONCLUSIONS: Male patients with high incidence of lung neoplasms,and the most common lesions in the right lung,especially in right upper lobe.Adenocarcinoma has become the most common pathological type in lung cancer.
Clinical pathology
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Objective To evaluate the significance of fibrobronchoscopy for the diagnosis of lung cancer and explore the relationship of pathological types of lung cancer with sex, age and clinical diagnosis. Methods The pathological diagnose data of 1470 patients with lung cancer diagnosed by fibrobronchoscopy was retrospectively analyzed. Results Out of the 1470 patients 1007 were male (68.50 per cent), 463 were female (31.50 percent). The age of the eldest patient was 87, the youngest was 17, average age was 57.41. Among the data of pathological diagnose, the percentage of squamous carcinoma was the largest, which was 39.52 percent (581 cases), adenocarcinoma was 25.44 percent (374 cases), small cell lung cancer was 24.35 percent (358 cases), quesonable lung cancer is 5.71 percent (84 cases), lung cancer that difficult to typing was 2.11 percent (31 cases), other pathological types was 2.86 percent (42 cases). The number of male with lung cancer was significantly greater than that of female (P 0.01). Male was susceptible to squamous carcinoma(P 0.01), while female was more susceptible to adenocarcinoma and small cell lung cancer(P 0.01, (P 0.05). Conclusion The fibrobronchoscopic examination is very important in the pathological diagnosis of lung cancer; The pathological type is different in different age and sex.
Squamous carcinoma
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