Interleukin-4 and interferon-γ are possible allergic markers in pediatric patients with β-lactam hypersensitivity
3
Citation
27
Reference
10
Related Paper
Citation Trend
Abstract:
Background: β-lactam agents are known to elicit T-cell-mediated immune responses that play a central role in the onset of allergic reactions, but the involvement of specific type of cytokines in drug allergy remains largely unexplored in humans. Objectives: This study was undertaken to investigate the role of cytokines involvement in pediatric patients with β-lactam hypersensitivity and to determine whether involvement of cytokines in drug-mediated reactions are important for the perspective of allergic patient's management. Methods: β-lactam-induced hypersensitivity reactions in eighty pediatric patients were determined by clinical manifestations and skin prick or intradermal testing. Production of T-helper (Th) type-1 cytokine interferon (INF)-γ, Th-2 cytokine interleukin (IL)-4, regulatory T-cell cytokine IL-10, and other cytokines IL-6 and IL-12 were determined by sandwich ELISAs. Results: Diagnosis of β-lactam allergy was confirmed in 53 pediatric patients. IL-4 secretion in patients' sera was significantly higher as compared with healthy controls (P < 0.05). However, INF-γ level in patients' sera was significantly lower as compared with controls (P < 0.05). No significant alterations were found in the protein secretion of IL-10, IL-12, and IL-6 in allergic patients as compared with controls (P > 0.05). Conclusion: We conclude that IL-4 is specific marker for the diagnosis of β-lactam-induced hypersensitivity. Moreover, IL-4 in combination with INF-γ is more sensitive for the diagnosis of these reactions. This study also concludes that both IL-4 and INF-γ may play an active role in the onset of allergic reactions against β-lactam antibiotics.Keywords:
Beta-lactam
Lactam
Interferon γ
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantiospecific synthesis of (-)-tabtoxinine .beta.-lactamRoland E. Dolle, Chun Sing Li, Riccardo Novelli, Lawrence I. Kruse, and Drake EgglestonCite this: J. Org. Chem. 1992, 57, 1, 128–132Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/jo00027a024https://doi.org/10.1021/jo00027a024research-articleACS PublicationsRequest reuse permissionsArticle Views484Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Beta-lactam
Lactam
BETA (programming language)
Cite
Citations (32)
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHemiketal formation and subsequent intramolecular acylation of an N-hydroxy .beta.-lactamMatthew A. Williams, Marvin J. Miller, and Nigam P. RathCite this: J. Org. Chem. 1991, 56, 3, 1293–1296Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/jo00003a066https://doi.org/10.1021/jo00003a066research-articleACS PublicationsRequest reuse permissionsArticle Views196Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Beta-lactam
Lactam
Intramolecular reaction
Cite
Citations (12)
The key intermediate of monocyclic beta-lactams, N-benzyloxycarbonyl-3 S-amino-2-oxoazetidine(Ⅲ),was synthesized from L-( + )-2,3-diaminopropanoie acid(Ⅰ) by Ph_3P—(PyS)_2—CH_3CN system and N-benzyloxycarbonylation. Ⅰ was prepared from L(+)-aspartic acid by Schmidt rearrangement.Three derivatives(Ⅷa～c) of this monocyclic beta-lactam were prepared and their biological activities evaluated.
Lactam
Beta-lactam
Aspartic acid
BETA (programming language)
Cite
Citations (0)
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConversion of amino acids to .beta.-lactam derivatives via cyclopropanoneHarry H. Wasserman and Edward GlazerCite this: J. Org. Chem. 1975, 40, 10, 1505–1506Publication Date (Print):May 1, 1975Publication History Published online1 May 2002Published inissue 1 May 1975https://pubs.acs.org/doi/10.1021/jo00898a031https://doi.org/10.1021/jo00898a031research-articleACS PublicationsRequest reuse permissionsArticle Views240Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Beta-lactam
Lactam
BETA (programming language)
Cite
Citations (31)
Abstract Phenoxyacetylchlorid (I) reagiert mit dem Anisidin (II) in Gegenwart von Triäthylamin zu einem Gemisch der E‐ und Z‐Azetidinone (III).
Beta-lactam
Lactam
Cite
Citations (0)
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMarine alkaloids. 12. Chartellines, halogenated .beta.-lactam alkaloids from the marine bryozoan Chartella papyraceaUffe Anthoni, Lionel Chevolot, Charles Larsen, Per H. Nielsen, and Carsten ChristophersenCite this: J. Org. Chem. 1987, 52, 21, 4709–4712Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/jo00230a010https://doi.org/10.1021/jo00230a010research-articleACS PublicationsRequest reuse permissionsArticle Views395Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Beta-lactam
Lactam
Cite
Citations (84)
A beta-Lactams show high chemical reactivity and ease of molecular rearrangement and a r e therefore potential synthons of value.The present communication reviews the relevant literature and describes observation made in our laboratory and elsewhere.Suitably substituted beta-Lactams can lead to multiheteroatom cyclic compounds of various sizes including derivatives of carbostyril, coumarin, diazepin, oxazepin and thiazepin of potential interest to synthetic and medicinal chemists.
Synthon
Beta-lactam
Lactam
Cleavage (geology)
BETA (programming language)
Cite
Citations (37)
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of a 1,3-bridged .beta.-lactam: a novel, anti-Bredt .beta.-lactamRobert M. Williams and Byung H. LeeCite this: J. Am. Chem. Soc. 1986, 108, 20, 6431–6433Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://pubs.acs.org/doi/10.1021/ja00280a075https://doi.org/10.1021/ja00280a075research-articleACS PublicationsRequest reuse permissionsArticle Views481Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Beta-lactam
Lactam
BETA (programming language)
Cite
Citations (36)
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic structures of cephalosporins and penicillins. 4. Modeling acylation by the .beta.-lactam ringDonald B. Boyd, Robert B. Hermann, David E. Presti, and Max M. MarshCite this: J. Med. Chem. 1975, 18, 4, 408–417Publication Date (Print):April 1, 1975Publication History Published online1 May 2002Published inissue 1 April 1975https://pubs.acs.org/doi/10.1021/jm00238a018https://doi.org/10.1021/jm00238a018research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lactam
Beta-lactam
Moxalactam
Cephem
Cite
Citations (54)