2316 Efficacy and toxicity of second-line chemotherapy in patients with advanced oesophageal squamous cell carcinoma progressing after a first line of 5-fluorouracil and platinum-based therapy: An AGEO retrospective multicentric study
Claire AuzolleOlivier DubreuilAstrid PozetRomain CoriatMarion DhoogeMichel DucreuxM. MonsBertrand BrieauIsabelle BaumgaertnerJean-Marie GornetA. Li évreClara LocherFlorence MaryFranck BonnetainB. Landi
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N~1-Hydroxyalkyl-5-fluorouracils, diethyl α-5-fluorouracil-N~1-malonate, dimethylα-5-fluorouracil-N~1-methylsuccinate, α-5-fluorouracil-N~1-malonic acid and α-5-fluorouracil-N~1-methylsuccinic acid were synthesized and structurally confirmed by ~1H NMR, IR, UVand elemental analysis. The antitumor activity of five 5-fluorouracil derivatives were testedagainst Ehrlish ascites carcinoma (EAC) in mice and compared with that of 5-fluorouracil-N~1-acetic acid and 5-fluorouracil-N~1-propanoic acid. 5-Fluorouracil-N~1-substituted dicarboxy-lic acids exhibited no antitumor activity. N~1-Hydroxyethyl-5-fluorouracil and N~1-hydroxy-propyl-5-fluorouracil, with lower toxicity than 5-fluorouracil, showed an inhibition ratio of52.40% and 67.32%, respectively.
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Malonic acid
Propanoic acid
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5-Fluorouracil,Leucovorin and Carmofur Combination in Treatment for Advanced Large-intestinal Cancer
To investigate the effect of combination of 5 fluorouracil,leucovorin and carmofur or 5 fluorouracil and leucovorin in treatment for advanced large intestinal cancer.From October 1998 to April 2000,36 cases who suffered from advanced large intestinal cancer were divided into two groups randomly,the treatment group with 5 fluorouracil,leucovorin and carmofur combination;control group with 5 fluorouracil and leucovorin.The overall response rates was 55.5% in treatment group and 27.7% in control group.[Conclusion]5 fluorouracil,leucovorin and carmofur combination is more effective than 5 fluorouracil and leucovorin combination for advanced large intestinal cancer.
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Thymic carcinoma
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The sensitivity of human gastric cancer tissue to 5-fluorouracil (5-FU) and its analogues l-(2-tetrahydrofuryl)-5-fluorouracil (FT), UFT and 1-hexylcarbamoyl-5-fluorouracil (HCFU) was determined, using the in vivo subrenal capsule (SRC) assay. The relative variation of tumor size (ΔTS/TS₀) was calculated as follows: ΔTS/TS₀ = (TS6-TS₀/TS₀) x 100%, where TS6 was the tumor size on day 6 and TS₀ on day 0. The chemosensitivity was considered to be positive when ΔTS/TS₀ in the treated group decreased to below -10%. For their cytotoxic effects, 5-FU analogues are converted to 5-FU and positive correlations were noted between the tumor sizes of 5-FU and its analogues (5-FU vs. FT, r = 0.737; 5-FU vs. UFT, r = 0.653; 5-FU vs. HCFU, r = 0.709), in gastric tissues from 22 patients. The means ± SD of tumor size were -8.5 ± 11.5% for 5-FU, -8.3 ± 16.0% for FT, -18.1 ± 15.8% for UFT and -13.7 ± 13.4% for HCFU. Decrease in tumor size was marked in case of exposure to UFT, compared with that to 5-FU (p < 0.001), FT (p < 0.001) and HCFU (p < 0.05). 18% were sensitive to UFT and resistant to 3 other drugs. Thus, UFT proved to be the most effective among 5-FU and its analogues for decreasing the size of gastric cancer tissues.
Gastric carcinoma
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Aim To explore hemogram charge during supplemeatary VP for postoperative chemotherapy with oral squamous cell carcinoma and the reason for charge.Methods Hemogram charges were reviewed in 81 cases of oral squamous cell carcinoma(2000~2005)with supplemenfary VP for postoperative chemotherapy.Results All of the patients'hemogram have changed.Change of WBC is the most significant(P0.05),and that of PLT ranks the second(P0.05)while that of RBC is not notable.But one week chemotherapy,Condition of hemogram restores as normal as pre-chemotherapy.Conclusion Patients' hemogram during supplementary VP for postoperative chemotherapy with oral squamous cell carcinoma may take temporary change and will restore to its normal evel after one week.
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Actinic keratosis
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SummaryWe report the results of a phase III trial in which we compared 5-fluorouracil (5-FU) to 5-FU and folinic acid (FA) in 150 previously untreated metastatic colon cancer patients.Patients were randomized in the ratio of 1:2 to receive 5-FU (370 mg/m2, i.v., for 5 days) in arm A or equidose 5-FU plus FA (200 mg/m2, i.v., for 5 days) for arm B, each cycle being repeated every 4 weeks. Five of 49 evaluable arm A patients (10.2%) and 31 of 97 arm B (31.9%) achieved a complete or partial response (p ≤ 0.01). Median survival time of arm A patients was 6 months (mean: 6.18), while it was 8 months (mean: 9.01) for arm B cases (p ≤ 0.05).In conclusion, our data indicate that FA can enhance 5-FU activity and that this combination is an effective palliative treatment for metastatic colon cancer patients.Key Words: 5-FUFAadvanced colon cancerrandomized trial
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Objective To study the pharmacokinetics of 5-fluorouracil based sustained release chemotherapy.Methods 30 cases with malignant tumor of digestive tract were devided into two groups.Study group received 5-fluorouracil based sustained release chemotherapy,while control group received systematic chemotherapy.Results 5-fluorouracil based sustained release chemotherapy had high apparent volume of distribution,long half time and small area under the curve compared with systematic chemotherapy.Conclusion Sustained release chemotherapy can prolong the regional action time and improve the regional concentration of chemotherapeutic drugs.
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