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    [Breast cancer: patient care, rehabilitation, psychooncology].
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    Abstract:
    The development of a recommendation was intended for the follow-up of breast cancer patients treated with curative intent in Hungary. Follow-up includes the permanent contact with and health education of the patient, the surveillance and control of the adverse effects of oncological therapies or radiotherapy, the screening of metachron cancers, and the comprehensive (physical, psychological and social) rehabilitation of the patient. The early detection of local/regional tumor relapse is essential with careful follow-up, but there is no need for screening of distant metastases by means of imaging studies or tumor marker tests. If adjuvant endocrine therapy is needed, optimal adherence should be ensured with supportive therapy. In rare cases, special issues such as breast cancer risk/genetic mutation, pregnancy are raised, which should be thoughtfully discussed in view of recent advances in oncology. Follow-up is generally practised by the oncologist, however, in some cases the social worker, the physiotherapist, the psychooncologist, or in special cases, the lymphoedema expert is to be involved. The follow-up approach should be comprehensive and holistic.A nemzetközi ajánlások és legújabb irodalmi adatok áttekintése alapján kívántunk ajánlást adni az emlõrák miatt kuratív ellátásban részesült betegek gondozásának magyarországi gyakorlatához. A gondozás magába foglalja a beteggel történõ kapcsolattartást, egészségnevelést, a betegség tüneteinek, illetve az onkológiai kezelés és a sugárterápia mellékhatásainak felismerését, menedzselését, a további daganatokra vonatkozó szûrést és a beteg teljes körû (fizikai, lelki és szociális) rehabilitációját. Fontos a lokális/regionális daganatkiújulás korai detektálása gondos követéssel, de nincs szükség a távoli áttétek kutatására képalkotó vizsgálatokkal vagy tumormarker-meghatározással. Amennyiben adjuváns hormonterápia szükséges, a jó adherenciát a mellékhatások megfelelõ szupportálásával segítsük. Egyes esetekben speciális kérdések (emlõrákrizikó/mutációhordozás, gyermekvállalás) is felmerülhetnek, ezek tapintatos, gondos és hozzáértõ megbeszélése az onkológia fejlõdésének tükrében elengedhetetlen. A gondozást általában onkológus végzi, de a beteg ellátásában szükség lehet a team szociális munkás, fizioterapeuta és pszichoonkológus tagjának, olykor nyiroködéma-szakembernek a bevonására. A gondozás legyen teljes körû és holisztikus szemléletû.
    MicroRNA (miRNA), which are stably present in serum, have been reported to be potentially useful for detecting cancer. In the present study, we examined the expression profiles of serum miRNA in several large cohorts to identify novel miRNA that can be used to detect early stage breast cancer. We comprehensively evaluated the serum miRNA expression profiles using highly sensitive microarray analysis. A total of 1280 serum samples of breast cancer patients stored in the National Cancer Center Biobank were used. In addition, 2836 serum samples were obtained from non‐cancer controls, 451 from patients with other types of cancers, and 63 from patients with non‐breast benign diseases. The samples were divided into a training cohort including non‐cancer controls, other cancers and breast cancer, and a test cohort including non‐cancer controls and breast cancer. The training cohort was used to identify a combination of miRNA that could detect breast cancer, and the test cohort was used to validate that combination. miRNA expressions were compared between patients with breast cancer and non‐breast cancer, and a combination of five miRNA (miR‐1246, miR‐1307‐3p, miR‐4634, miR‐6861‐5p and miR‐6875‐5p) was found to be able to detect breast cancer. This combination had a sensitivity of 97.3%, specificity of 82.9% and accuracy of 89.7% for breast cancer in the test cohort. In addition, this combination could detect early stage breast cancer (sensitivity of 98.0% for Tis).
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    The purposes of this study were to (1) to identify the causes of cancer in breast cancer survivors in Taiwan; and (2) to investigate the influence of demographic characteristics and breast cancer-related factors on the cause of cancer.This study details the related investigative results on survivors with breast cancer using a descriptive and correlational design. A convenience sampling approach was employed. A structured questionnaire was used to assess the participants.A total of 230 breast cancer survivors completed the questionnaire. Low-scoring cause of cancer participants were older adults (OR = 2.49, p<0.05) who were already of menopausal status (OR = 2.28, p < 0.05). Around 72% of participants agreed high responsibility. Our breast cancer survivors felt stress had caused their breast cancer.These findings are helpful in understanding the relationship between cause of cancer and related factors in breast cancer survivors.
    Female breast cancer recently surpassed lung cancer and became the most commonly diagnosed cancer worldwide. As per the recent data from WHO, breast cancer accounts for one out of every 8 cancer cases diagnosed among an estimated 2.3 million new cancer cases. Breast cancer is the most prevailing cancer type among women causing the highest number of cancer-related mortality. It has been estimated that in 2020, 68,5000 women died due to this disease. Breast cancers have varying degrees of molecular heterogeneity; therefore, they are divided into various molecular clinical sub types. Recent reports suggest that type 2 diabetes (one of the common chronic diseases worldwide) is linked to the higher incidence, accelerated progression, and aggressiveness of different cancers; especially breast cancer. Breast cancer is hormone-dependent in nature and has a cross-talk with metabolism. A number of antidiabetic therapies are known to exert beneficial effects on various types of cancers, including breast cancer. However, only a few reports are available on the role of incretin-based antidiabetic therapies in cancer as a whole and in breast cancer in particular. The present review sheds light on the potential of incretin based therapies on breast cancer and explores the plausible underlying mechanisms. Additionally, we have also discussed the sub types of breast cancer as well as the intricate relationship between diabetes and breast cancer.
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    The majority of malignant tumors occurring in the nasopharynx are carcinomas usually of the epidermoid type, either undifferentiated or of varying degree of differentiation. Lymphoepithelioma is now accepted by most authorities as a poorly differentiated variant of epidermoid carcinoma. The diagnosis of nasopharyngeal carcinoma is often made after a long delay when the disease has already become advanced. This is largely because nasopharyngoscopy is a difficult procedure except in the hands of the expert. It is not possible to perform this procedure in the presence of trismus (not a rare complication resulting from the lateral spread of the carcinoma to the pterygoid muscles), or when there is a hyperactive pharyngeal reflex, in which case general anesthesia is required. Therefore, if a method which offers simplicity of execution and an acceptable degree of reliability in demonstrating nasopharyngeal lesions could be found, it would go a long way to minimize the diagnostic
    Nasopharyngeal cancer
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