[Clearance of fat emulsions and dual energy source in total parenteral nutrition support in post trauma/sepsis patients].
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Nutrition therapy in sepsis is challenging and differs from the standard feeding approach in critically ill patients. The dysregulated host response caused by infection induces progressive physiologic alterations, which may limit metabolic capacity by impairing mitochondrial function. Hence, early artificial nutrition should be ramped-up and emphasis laid on the post-acute phase of critical illness. Caloric dosing is ideally guided by indirect calorimetry, and endogenous energy production should be considered. Proteins should initially be delivered at low volume and progressively increased to 1.3 g/kg/day following shock symptoms wane. Both the enteral and parenteral route can be (simultaneously) used to cover caloric and protein targets. Regarding pharmaconutrition, a low dose glutamine seems appropriate in patients receiving parenteral nutrition. Supplementing arginine or selenium is not recommended. High-dose vitamin C administration may offer substantial benefit, but actual evidence is too limited for advocating its routine use in sepsis. Omega-3 polyunsaturated fatty acids to modulate metabolic processes can be safely used, but non-inferiority to other intravenous lipid emulsions remains unproven in septic patients. Nutrition stewardship, defined as the whole of interventions to optimize nutritional approach and treatment, should be pursued in all septic patients but may be difficult to accomplish within a context of profoundly altered cellular metabolic processes and organ dysfunction caused by time-bound excessive inflammation and/or immune suppression. This review aims to provide an overview and practical recommendations of all aspects of nutritional therapy in the setting of sepsis.
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Critical Care Medicine: March 2007 - Volume 35 - Issue 3 - p 988-989 doi: 10.1097/01.CCM.0000257472.00249.02
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Trauma, sepsis, and burns cause abnormal manifestations in the body. These manifestations can cause alterations in body metabolism, which complicates nutritional management. Goals of nutrition support with assessment modifications for a constantly changing population are reviewed. Patients in such stress states as burns, trauma, and sepsis many times need altered nutrition. This article outlines guidelines for total parenteral formula modification and monitoring, and discusses other complications such as drug interactions with parenteral formulas.
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Sepsis is associated with profound catabolism and hypermetabolism that complicate provision of nutritional support. These metabolic changes are caused by inflammatory mediators involved in the septic process and cannot be reversed by nutritional means. High protein isocaloric nutritional regimens are recommended if possible, in association with aggressive measures to control the sepsis. However, nutritional therapy and its complications may also affect the incidence and course of sepsis. Hyperglycemia and conventional intravenous fat emulsions have been shown to increase susceptibility to infection. Enteral nutrition is associated with fewer infectious complications than parenteral nutrition, at least in severely injured patients. Recently nutritional formulations have been introduced that contain novel substrates that enhance various aspects of immunity. Several studies have suggested that this immunonutrition reduces infection risk in the critically ill, and preliminary findings suggest it may even have an effect on survival in sepsis.
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Systemic inflammatory responses to severe trauma and surgical illnesses may be partly responsible for numerous complications, including sepsis, multiple organ failure and unregulated hypermetabolism leading to protein-calorie malnutrition. The integrity of the gastrointestinal tract appears to be an important factor in the pathogenesis of the systemic inflammatory response and sepsis. Resuscitation and nutrition support strategies for preserving gut mucosal integrity have therefore been strongly promoted. This review summarizes the scientific rationale for emphasizing enteral nutritional support of surgical patients, discusses some important limitations of enteral feeding and argues for a flexible approach to nutrition support for these complex patients.
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Sepsis is a growing global problem with high health care costs. Therefore, it is important to start treatment on time. Nutrition support is the main element of modern therapy for sepsis. Enteral nutrition has some advantage to parenteral nutrition because it prevents bacterial translocation into systemic circulation, thus reducing the number of infections. Appropriate nutritional support has a direct impact on the patient clinical outcome.
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A major goal of this review article is to show that nutritional physiology in normal man is rather different from patients bearing an inflammatory response. Known nutrients and a variety of energy sources reveal pharmacological actions during such metabolic circumstances. An understand of the pathophysiologic state of sepsis is essential for adequate nutritional support especially in this patient population.
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