Norfloxacin in the treatment of uncomplicated gonorrhoeae in nonpregnant females.
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Etude de l'efficacite et de la toxicite chez 88 femmes non enceintes a raison d'une dose unique de 800 mg. Le taux de guerison est de 100%. Des effets secondaires (nausees) sont rencontres dans 2 casCite
Cervical specimens were collected from 1688 women attending a gynaecological clinic for induced abortion between February and December 1978. Thirteen (0.77%) women had positive culture results for Neisseria gonorrhoeae. Among those women who had a completed family or who came from outside Rotterdam or from outside the neighboring Rijnmond area, the isolation rate was very low. None of the women with positive culture results developed salpingitis after abortion; all of them had been treated prophylactically with tetracycline. No reasons appear to exist for considering women who seek abortions to be in a high-risk group for cervical gonorrhoea. Whether or not antibiotic prophylaxis should be given for the prevention of salpingitis following abortion requires further study of potentially pathogenic micro-organisms inhabiting the vagina and cervix for women applying for abortion.
Neisseria gonorrhoeae
Salpingitis
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Neisseria gonorrhoeae
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During a cross sectional study on the prevalence and incidence of gonorrhoea, Neisseria gonorrhoeae was isolated from 185 people aged between 16 and 60 years. In vitro activity of six antimicrobial antibacterial agents, penicillin, erythromycin, tetracycline, cotrimoxazole, ceftriaxone and norfloxacin on the isolated N. gonorrhoeae were carried out. The results obtained showed that, of all 111 isolates, 48 (43.2 pc) were penicillinase producing N. gonorrhoeae (PPNG) and 63 (56.8 pc) were non PPNGs. Over 90 pc of both PPNG and non PPNG isolates were sensitive to tetracyline and erythromycin. Seventy five pc of the PPNG and 45 pc non-PPNG were not sensitive to two units of penicillin. Both PPNG and non-PPNG were less sensitive to cotrimoxazole 25 micrograms. Norfloxacin and ceftriaxone were over 70 pc effective but were extremely expensive for most people who got infected.
Neisseria gonorrhoeae
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In an open study, 70 patients with uncomplicated anogenital Neisseria gonorrhoeae infection were evaluated to determine the efficacy and safety of a single oral dose of norfloxacin (800 mg). Norfloxacin cured all 31 male urethral and 25 endocervical infections. All 63 isolates of N. gonorrhoeae tested were inhibited by 0.05 microgram of norfloxacin per ml.
Neisseria gonorrhoeae
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In an open prospective study, single oral doses of norfloxacin (800 mg) and thiamphenicol (2.5 g) were used to treat, respectively, 122 and 46 consecutive patients with uncomplicated gonorrhea. Neisseria gonorrhoeae was eradicated from 119 (97.5%) patients treated with norfloxacin and from 35 (76.0%) patients treated with thiamphenicol. Norfloxacin treatment failure was not related to drug resistance or to insufficient absorption of the drug. Thiamphenicol failure correlated with low in vitro susceptibility of the infecting strain. In a single oral dose of 800 mg, norfloxacin appeared to be an excellent alternative treatment regimen for uncomplicated gonorrhea in an area with a high prevalence of penicillin-resistant gonococci.
Thiamphenicol
Neisseria gonorrhoeae
Regimen
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In 12 recent clinical studies, norfloxacin given in various dosage regimens was shown to be highly effective in treating 1,588 gonococcal infections in 1,486 patients. A single oral dose of norfloxacin 800 mg cured 99.2% of 783 patients with penicillinase producing strains of Neisseria gonorrheae (PPNG) and non-penicillinase producing N. gonorrheae (NPPNG) causing urethritis, cervicitis and anorectal infections. A single oral dose of 800 mg of norfloxacin was found to be an effective alternative to a 2 g intramuscular dose of spectinomycin and superior to a 2.5 g oral dose of thiamphenicol for the treatment of PPNG urethritis or cervicitis. Its efficacy in treatment of NPPNG infections was shown to be similar to that of a single oral dose of 3.5 g of ampicillin plus 1 g of probenecid. Mild and transient gastrointestinal and neurological adverse events occurred in 3.3% of patients treated with norfloxacin 800 mg. Norfloxacin 800 mg as a single dose is recommended as an effective and safe single-dose treatment of urethritis, cervicitis and anorectal infections caused by PPNG or NPPNG.
Probenecid
Spectinomycin
Neisseria gonorrhoeae
Thiamphenicol
Cervicitis
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Neisseria gonorrhoeae
Beta-lactamase
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Norfloxacin, an orally administered quinoline carboxylic acid that is structurally related to nalidixic acid, has been shown to be highly active in vitro against penicillinase-producing Neisseria gonorrhoeae. Ninety-two men with culture-proved gonococcal urethritis, 46 per cent with penicillinase-producing N. gonorrhoeae, and 27 per cent with non-penicillinase-producing N. gonorrhoeae that was resistant to penicillin were given either 1200 mg of norfloxacin divided into two equal oral doses four hours apart (59 patients) or 2 g of spectinomycin intramuscularly (33 patients). All patients in both treatment groups were cured. No adverse reactions were reported in either group. We conclude that a two-dose, single-day regimen of orally administered norfloxacin is effective therapy for uncomplicated urethritis caused by penicillin-resistant strains of N. gonorrhoeae.
Neisseria gonorrhoeae
Penicillin resistance
Neisseriaceae
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Neisseria gonorrhoeae
Neisseriaceae
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Norfloxacin is a quinolone derivative with demonstrated activity against Neisseria gonorrhoeae. The MIC90 against penicillinase- and non-penicillinase producing N. gonorrhoeae is 0.06 mg/l and 0.015 mg/l respectively. The drug is rapidly absorbed with a single oral dose of 800 mg producing peak serum levels of 2.45 mg/l. In this open, uncontrolled study, 70 patients with laboratory confirmed, uncomplicated infections with N. gonorrhoeae were entered to determine the efficacy and safety of a single oral dose of norfloxacin 800 mg. Thirty-one males and 27 females were evaluated for efficacy with 34 males and 25 females evaluated for safety. Norfloxacin cured all 31 urethral and two pharyngeal infections in men. All 25 females with endocervical infections and six with rectal involvement were also cured. The single treatment failure occurred in a woman who had persistent pharyngeal infection. All isolates of N. gonorrhoeae were inhibited by 0.05 mg/l of norfloxacin. The incidence of adverse effects was 23.7% but all were mild, required no specific therapy and cleared without sequelae. In this study, norfloxacin proved to be an effective agent in the therapy of uncomplicated gonococcal infection in males and females. It has previously been proven to be useful in the therapy of gonococcal infections due to penicillinase-producing N. gonorrhoeae and the value of this drug as a first line choice in the treatment of gonococcal infections is discussed.
Neisseria gonorrhoeae
Quinolone
Gonococcal infection
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