[Gene expression induced by the deficiency of essential micro nutrients].
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Expression (computer science)
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Dosage compensation
Pair-rule gene
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Afipia birgiae is an alphaproteobacterium from the family Bradyrhizobiaceae, growing in amoebae, and a potential human pathogen. We sequenced the genome of type strain 34632(T). It is composed of 5,325,467 bp and contains 5,160 protein-coding genes and 53 RNA genes, including 3 rRNA genes.
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Abstract The genetic interactions among mutations that define eight distinct loci involved in light-regulated development in Arabidopsis thaliana are described. The mutations in these eight genes define two distinct phenotypic classes with opposite characteristics. Recessive mutations in either one of two genes, DET1 or DET2, result in dark-grown plants that develop as light-grown wild-type seedlings. Mutants in the second class exhibit a reduced response to light Recessive mutations in any one of five genes, HY1, HY2, HY3, HY5, or HY6 cause reduced responses to red-light Four of these genes, HY1,2,3, and 6, affect the activity of one or all of the red-light photoreceptors, the phytochromes. The HY4 gene product is involved in blue-light perception or action. The experiments described here examine how these eight genes interact to control a particular event, the switch from developmental arrest in the dark (etiolation) to growth in the light (deetiolation). The phenotypes of doubly mutant strains suggest a hierarchical regulatory network among these genes in the control of the switch from etiolated to de-etiolated growth strategies.
Etiolation
Phytochrome
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Journal Article A novel PCR method for amplifying exons (or genes) over intragenic (or intergenic) regions in the genome Get access Ping Fu, Ping Fu Howard Florey Institute of Experimental Physiology and MedicineParkville, Victoria 3052, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Bronwyn Evans Bronwyn Evans * Howard Florey Institute of Experimental Physiology and MedicineParkville, Victoria 3052, Australia * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 20, Issue 11, 11 June 1992, Page 2903, https://doi.org/10.1093/nar/20.11.2903 Published: 11 June 1992 Article history Received: 25 November 1991 Published: 11 June 1992
Intergenic region
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Summary The CONSTANS ( CO ) gene of Arabidopsis plays a key role in the photoperiodic flowering pathway. To investigate photoperiod responses in cereals in more detail, we isolated three kinds of CO/Hd1 (rice ortholog of CO ) homolog from hexaploid wheat, derived from the A, B, and D genomes and designated as wheat ortholog of CO from A genome ( TaHd1‐1), TaHd1‐2 , and TaHd1‐3 , respectively. They were highly similar to each other and to Hd1 , and in addition harbored two conserved regions: two zinc finger motifs and CONSTANS, CONSTANS‐LIKE and TIMING OF CAB EXPRESSION 1 (CCT) domain like CO/Hd1 . They were located on the long arm of the homoeologous chromosome 6. TaHd1‐2 harbored a 63‐bp deletion at the promoter region containing the GATA‐1 box, and consequently, we detected no subsequent transcript. The TaHd1‐1 genomic clone was introduced to a rice line deficient in Hd1 function. Transgenic plants complemented the functions of rice Hd1: they promoted heading under short‐day (SD) conditions and delayed it under long‐day (LD)/natural conditions, indicating that Hd1 proteins from SD and LD plants share common structures and functions.
Homology
Genetically modified rice
Common wheat
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Journal Article A BamHI polymorphism in the human EVI2A gene (human homolog of the murine gene Evi-2) Get access W. Xu, W. Xu * CRC Human Cancer Genetics Group, Department of Pathology, University of CambridgeUK * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar L. Liu, L. Liu CRC Human Cancer Genetics Group, Department of Pathology, University of CambridgeUK Search for other works by this author on: Oxford Academic PubMed Google Scholar B.A.J. Ponder B.A.J. Ponder CRC Human Cancer Genetics Group, Department of Pathology, University of CambridgeUK Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 9, 11 May 1991, Page 2520, https://doi.org/10.1093/nar/19.9.2520 Published: 11 May 1991
Cancer genetics
Human genetics
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To accelerate gene discovery and facilitate genetic mapping in the protozoan parasite Toxoplasma gondii, we have generated >7000 new ESTs from the 5′ ends of randomly selected tachyzoite cDNAs. Comparison of the ESTs with the existing gene databases identified possible functions for more than 500 new T. gondii genes by virtue of sequence motifs shared with conserved protein families, including factors involved in transcription, translation, protein secretion, signal transduction, cytoskeleton organization, and metabolism. Despite this success in identifying new genes, more than 50% of the ESTs correspond to genes of unknown function, reflecting the divergent evolutionary status of this parasite. A newly recognized class of genes was identified based on its similarity to sequences known only from other members of the same phylum, therefore identifying sequences that are apparently restricted to the Apicomplexa. Such genes may underlie pathways common to this group of medically important parasites, therefore identifying potential targets for intervention.
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In order to identify genes involved in pathogenicity, we compared the closely related species Globodera pallida (GP) and Globodera “mexicana” (GM) that have different host ranges and are able to produce viable and fertile hybrids. Three pioneer genes were previously identified as differentially expressed between GP and GM: GPLIA7 and GPLIB3 were found to be more highly expressed in GP, whereas GMLIVG9 was found more highly expressed in GM. In this study, we showed that Ia7 and IVg9 genes probably encode products secreted by the subventral oesophageal glands and the dorsal oesophageal gland, respectively. No Blast homolog was found in the databases, but a metridin-like ShK (Stichodactyla helianthus) toxin domain was identified in the Ia7 sequence. Analysis of the full-length sequences of these 2 genes between GP and GM revealed a high level of interspecies variability (8% for the Ia7 transcript and 17% for the IVg9 transcript) and a high proportion (90%) of nonsynonymous mutations among the substitutions observed. This suggested that these 2 pioneer genes are under strong diversifying selection pressures and therefore may be involved in pathogenicity. Further investigations of the sequence polymorphism of Ia7 and IVg9 genes were conducted in GP × GM hybrid lines that were selected in laboratory conditions for their different ability to develop on potato and black nightshade. As similar sequences were obtained for all the hybrid lines tested independently of their pathogenicity status, no correlation could be established between IA7 and IVG9 amino acid changes and the host range differences observed between GP and GM.
Nonsynonymous substitution
Globodera pallida
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Conserved sequence
Coding region
Negative selection
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